A role for antioxidants in acclimation of marine derived pathogenic fungus (NIOCC 1) to salt stress

Ravindran, Chinnarajan; Varatharajan, Govindaswamy R.; Rajasabapathy, Raju; Vijayakanth, S.; Kumar, Alagu Harish; Meena, Ram Murthi

doi:10.1016/j.micpath.2012.07.004

Cited by 17 publications

(13 citation statements)

References 81 publications

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“…2010 ). Unfortunately no strains or sequences could be obtained for our phylogenetic analysis and it seems to represent another hitherto undescribed taxon ( Ravindran et al 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Phialosimplex salinarum, a new species of Eurotiomycetes from a hypersaline habitat

et al. 2014

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Salt mines represent an extreme environment with hypersaline conditions, complete darkness, and low nutrient availability. The diversity of filamentous fungi in such habitats is largely unknown. Eight strains of an unknown fungus were isolated from water samples of the salt mine in Berchtesgaden (Bavaria, Germany). They could be assigned to the ascomycete genus Phialosimplex, based on their common characteristics of producing conidia in chains or in heads on single phialides. Species of this genus are hitherto known to cause mycoses in dogs and have been found in mummies. Using molecular and morphological methods, the isolates are established as a new species, Phialosimplex salinarum sp. nov. Basipetospora halophila is also transferred to Phialosimplex as P. halophila comb. nov.

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“…2010 ). Unfortunately no strains or sequences could be obtained for our phylogenetic analysis and it seems to represent another hitherto undescribed taxon ( Ravindran et al 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Phialosimplex salinarum, a new species of Eurotiomycetes from a hypersaline habitat

et al. 2014

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“…from hypersaline habitats, i.e. marine environments (Ravindran et al, 2012), and a salt mine (Greiner et al, 2014). In the last study, the isolated strains were established as a new species, namely Phialosimplex salinarum, and all strains were shown to degrade cellulose and proteins (Greiner et al, 2014).…”

Section: Results Derived From Cotton Swabsmentioning

confidence: 99%

Amid the possible causes of a very famous foxing: molecular and microscopic insight into Leonardo da Vinci's self‐portrait

Piñar

Tafer

Sterflinger

et al. 2015

Environ Microbiol Rep

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Summary Leonardo da Vinci's self‐portrait is affected by foxing spots. The portrait has no fungal or bacterial infections in place, but is contaminated with airborne spores and fungal material that could play a role in its disfigurement. The knowledge of the nature of the stains is of great concern because future conservation treatments should be derived from scientific investigations. The lack of reliable scientific data, due to the non‐culturability of the microorganisms inhabiting the portrait, prompted the investigation of the drawing using non‐invasive and micro‐invasive sampling, in combination with scanning electron microscope (SEM) imaging and molecular techniques. The fungus E urotium halophilicum was found in foxing spots using SEM analyses. Oxalates of fungal origin were also documented. Both findings are consistent with the hypothesis that tonophilic fungi germinate on paper metabolizing organic acids, oligosaccharides and proteic compounds, which react chemically with the material at a low water activity, forming brown products and oxidative reactions resulting in foxing spots. Additionally, molecular techniques enabled a screening of the fungi inhabiting the portrait and showed differences when different sampling techniques were employed. Swabs samples showed a high abundance of lichenized Ascomycota, while the membrane filters showed a dominance of A cremonium sp. colonizing the drawing.

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“…Hyper saline environments originated by the evaporation of water and precipitation of the sodium chloride (NaCl) eventually increases the salinity [17] . Fungi from hyper saline environments adapt to high salt condition with its antioxidant capacity [18] .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenum Secondary Metabolites

Dikmen¹

2017

ijps

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Dikmen, et al.: Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenumDevelopment of resistance to standard therapy and toxic side effects are the major challenges encountered in chemotherapy of colorectal cancer. Increasing evidence has shown the ability of natural products to overcome various challenging disorders. Since, the development of antibiotics, fungi have been shown to be a wide useful source of lead compounds for the development of new pharmaceuticals. Fungal secondary metabolites from extreme environments are remarkable due to their diverse components, which makes them interesting candidates for drug discovery. In order to discover novel active antimetastatic and antiangiogenic compounds, secondary metabolites of halotolerant Penicillium chrysogenum-1 isolated from Tuz Lake in Turkey and ethyl acetate extract of halotolerant P. chrysogenum-1 was prepared from the isolate of halotolerant P. chrysogenum-1 culture medium. Firstly, antioxidant activity of the extract was determined. Then cytotoxicity and cell proliferation were investigated by WST-1 assay and real-time cell analysis system-DP on human umbilical vein endothelial cells and colorectal carcinoma cells, respectively. Antiangiogenic effects on human umbilical vein endothelial cells were evaluated with cell migration and invasion assays by using real-time cell analysis system. Also, mRNA expression levels of metastasis and angiogenesis-related genes, VEGFA, VEGFB, EGFR, COX-10, ANGPT-1 and IL-8 were determined on both cell lines. Results indicated that halotolerant P. chrysogenum-1 extract exhibited significant antimetastatic and antiangiogenic effects. According to the real-time cell analysis system results, IC 50 concentrations of halotolerant P. chrysogenum-1 extract on Caco-2 and human umbilical vein endothelial cells were calculated as 55.2 and 37.89 µg/ml, respectively for 72 h. These results indicated that the secondary metabolites of halotolerant P. chrysogenum-1 extract could have the potential as a preventive and therapeutic agent in metastatic cancer processes.

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A role for antioxidants in acclimation of marine derived pathogenic fungus (NIOCC 1) to salt stress

Cited by 17 publications

References 81 publications

Phialosimplex salinarum, a new species of Eurotiomycetes from a hypersaline habitat

Phialosimplex salinarum, a new species of Eurotiomycetes from a hypersaline habitat

Amid the possible causes of a very famous foxing: molecular and microscopic insight into Leonardo da Vinci's self‐portrait

Evaluation of Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenum Secondary Metabolites

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