A role of fructose in urinary stone formation

Pavlova, Z Sh; Golodnikov, I.I.; Камалов, А А; Nizov, A N

doi:10.18565/urology.2019.16.114-118

Cited by 3 publications

(2 citation statements)

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“…A uric acid nidus might explain the high prevalence of apatite stones in AYA women with USD ( 23 ). However, such a relationship has only been hypothesized ( 24 ), but not proven in pediatric USD patients. Also, rather than fructose itself, high fructose corn syrup, which is the industry standard sweetener for soda and many foods, has to be considered as a potential risk factor ( 25 , 26 ).…”

Section: Potential Explanations For the Sex Disparity In Urinary Ston...mentioning

confidence: 99%

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

Filler,

Dave,

Ritter

et al. 2023

Front. Med.

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BackgroundUrinary stone disease (USD) historically has affected older men, but studies suggest recent increases in women, leading to a near identical sex incidence ratio. USD incidence has doubled every 10 years, with disproportionate increases amongst children, adolescent, and young adult (AYA) women. USD stone composition in women is frequently apatite (calcium phosphate), which forms in a higher urine pH, low urinary citrate, and an abundance of urinary uric acid, while men produce more calcium oxalate stones. The reasons for this epidemiological trend are unknown.MethodsThis perspective presents the extent of USD with data from a Canadian Province and a North American institution, explanations for these findings and offers potential solutions to decrease this trend. We describe the economic impact of USD.FindingsThere was a significant increase of 46% in overall surgical interventions for USD in Ontario. The incidence rose from 47.0/100,000 in 2002 to 68.7/100,000 population in 2016. In a single United States institution, the overall USD annual unique patient count rose from 10,612 to 17,706 from 2015 to 2019, and the proportion of women with USD was much higher than expected. In the 10–17-year-old patients, 50.1% were girls; with 57.5% in the 18–34 age group and 53.6% in the 35–44 age group. The roles of obesity, diet, hormones, environmental factors, infections, and antibiotics, as well as the economic impact, are discussed.InterpretationWe confirm the significant increase in USD among women. We offer potential explanations for this sex disparity, including microbiological and pathophysiological aspects. We also outline innovative solutions – that may require steps beyond typical preventive and treatment recommendations.

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Section: Potential Explanations For the Sex Disparity In Urinary Ston...mentioning

confidence: 99%

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

Filler,

Dave,

Ritter

et al. 2023

Front. Med.

View full text Add to dashboard Cite

show abstract

“…These stones are intricately linked to systemic metabolism and metabolic-related ailments, particularly evident in the case of uric acid stones. Several studies have highlighted substantial differences in various serum and urinalysis [2][3][4][5][6][7][8], as well as CT results between uric acid stone patients and non-uric acid patients.…”

Section: Introductionmentioning

confidence: 99%

Advancements in Uric Acid Stone Detection: Integrating Deep Learning with CT Imaging and Clinical Assessments in the Upper Urinary Tract

Jin,

Chen,

Sun

et al. 2024

Urol Int

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The incidence of urinary tract stones is increasing worldwide, with a notably high recurrence rate. Among upper urinary tract stones, a significant proportion comprises uric acid stones. This study aims to rapid and reliable identification of uric acid stones in the upper urethra by gathering comprehensive biochemical profiles, urinalysis, and CT scan data from 276 patients diagnosed with kidney and ureteral stones. Leveraging machine learning techniques, the goal is to establish multiple predictive models that can accurately identify uric acid stones.

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Features and relationships of metabolic syndrome components in men with androgen deficiency. Part 2. Disorders of carbohydrate and purine metabolism. Retrospective study data

Pavlova

Grevina

2021

Akušerstvo, ginekologiâ i reprodukciâ

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Introduction. There are few epidemiological data on violations of purine and carbohydrate metabolism in association with testosterone deficiency in men with overweight due to adipose tissue and metabolic syndrome (MS).Aim: to study the relationships between disturbances in carbohydrate and purine metabolism and testosterone level in men with excess adipose tissue and MS.Materials and Мethods. There were enrolled 64 overweight men to the study. The patients were divided into 3 groups based on the body mass index (BMI): group 1 – with overweight (n = 24), group 2 – with the first degree of obesity (n = 21), group 3 – with the second and third degree of obesity (n = 19). A correlation analysis was carried out between the data of carbohydrate and purine metabolism in relation to testosterone level and body composition, as well as additionally assessing the level of inter-group difference.Results. The relationship between the parameters of carbohydrate and purine metabolism and the level of total testosterone has been identified, and it's formed against the background of overdeveloped adipose tissue. A weak negative correlation was found across the sample between testosterone and glucose, insulin, and the НОМА-IR (Homeostasis Model Assessment of Insulin Resistance) index. That is, the higher the level of glucose, the НОМА-IR index, the lower the testosterone level. In addition, it was noted that an increase in BMI caused higher insulin levels. The number of patients with fasting blood glucose levels above 5.6 mmol/L and insulin resistance also increased. In the group with I degree of obesity, a negative correlation was found between the levels of total testosterone and uric acid.Conclusion. Thus, the thesis is confirmed that the more significant the violation of carbohydrate and purine metabolism, the more significant androgenic deficiency. It is obvious that the most effective solution in choosing a strategy for treating androgen deficiency and disorders of carbohydrate and purine metabolism in overweight men is to normalize body composition and get rid of excess adipose tissue.

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A role of fructose in urinary stone formation

Cited by 3 publications

References 0 publications

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

Advancements in Uric Acid Stone Detection: Integrating Deep Learning with CT Imaging and Clinical Assessments in the Upper Urinary Tract

Features and relationships of metabolic syndrome components in men with androgen deficiency. Part 2. Disorders of carbohydrate and purine metabolism. Retrospective study data

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