A Role of Piperine on Monosodium Urate Crystal-Induced Inflammation—An Experimental Model of Gouty Arthritis

Abstract

In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, tumor necrosis factor-α, and paw volume were increased significantly, and the activities of antioxidant status were in turn decreased in monosodium urate crystal-induced mice, whereas these changes were reverted to near normal levels upon piperine (30 mg/kg b.wt, i.p.) treatment. In vitro, piperine (50/100 ug/ml) suppressed the level of β-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated polymorphonuclear leucocytes in concentration-dependent manner when compared to control cells. Thus, the present study clearly indicated that piperine inhibit the monosodium urate crystal-induced inflammation and can be regarded as therapeutic drug for the treatment of acute gouty arthritis.

Anti-hyperuricemic effect of <i>Plantago depressa</i> Willd extract in rats

“…However, these existing anti-hyperuricemic agents possess undesirable effects. For example, allopurinol, which is the drug of choice, has side effects including gastrointestinal irritation, bone marrow suppression, hypersensitivity syndromes, hepatitis and worsening renal function, which are unable to be tolerated by approximately 5 % of patients [6]. Uricosuric agents are used in patients with allopurinol-allergic syndromes as well as in under excreters with normal renal function and no history of urolithiasis.…”

Comparative evaluation of xanthine oxidase inhibitory activity of Allium ceba L., AzadirachtaindicaA.Juss. and Piper betle L.

“…The plants like A.ceba and A.indica have rich flavonoids components (Finnegan et al, 1992) like quercetin which may show xanthine oxidase inhibitory activity. Piperaceous plants are known to contain various catecholic compounds which exhibit antioxidant activity, also piperine obtained from P. betle leaves has shown anti-inflammatory activity (Sabina et al, 2011). A. ceba (Haidari et al, 2008), A. indica and P. betle herbs (Murata et al, 2009) were possess to have xanthine oxidase inhibitory activity.…”

Preliminary screening of anti-inflammatory effect of phytochemicals on chemotaxis of human neutrophils

“…These compounds were assessed by the leading front method of chemotaxis to determine their effects on fMLP-induced chemotaxis of human neutrophils (Kinane et al, 1989). Other reports document anti-inflammatory potential of each one of these plant compounds (Budhiraja and Dhingra, 2014;HassanKhabbar et al, 2010;Nonose et al, 2014;Sabina et al, 2011) as well as nontoxic host effects McCrea et al, 2015).…”