A Rotational DNA Nanomotor Driven by an Externally Controlled Electric Field

Klapper, Yvonne; Sinha, Naveen; Ng, Timmy Wei Sheng; Lubrich, Daniel

doi:10.1002/smll.200901106

Cited by 34 publications

(25 citation statements)

References 38 publications

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“…In nature, biomolecular rotary motors drive bacterial flagella and ATP synthase. [1][2][3] Inspired by such rotary motors, various micro-/nanorotors have been developed, [4] including chemical-and light-driven artificial molecular rotors, [2,5] electricfield-driven DNA nanorotors, [6] chemical-fuel-driven catalytic micro-/nanorotors, [7][8][9] and electric-field-driven CNT-based NEMS. [10] A rotating magnetic field has also been used to rotate a variety of magnetic micro/nano-scale objects, such as single/ self-assembled beads, [11][12][13][14][15] rigid [16,17] and flexible wires, [18] and helical structures, [19,20] in fluid.…”

Section: Doi: 101002/adma201103818mentioning

confidence: 99%

Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport

et al. 2012

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Section: Doi: 101002/adma201103818mentioning

confidence: 99%

Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport

et al. 2012

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“…To address this issue, Bishop & Klavins [137] developed a motor based on a DNAzyme, which enabled them to selectively digest DNA/RNA hybrid waste products. Meanwhile, DNA devices have also been built exhibiting adaptive responses to a variety of other stimuli such as changes in pH [138][139][140][141], DNA hydrolysis [142][143][144], DNA polymerization [145], light [146,147] and even electric field [148].…”

Section: Dna Nanomachine: a Dynamic Dance Partnermentioning

confidence: 99%

Nucleic acid-based nanoengineering: novel structures for biomedical applications

LaBean

Leong

2011

Interface Focus.

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Nanoengineering exploits the interactions of materials at the nanometre scale to create functional nanostructures. It relies on the precise organization of nanomaterials to achieve unique functionality. There are no interactions more elegant than those governing nucleic acids via Watson -Crick base-pairing rules. The infinite combinations of DNA/RNA base pairs and their remarkable molecular recognition capability can give rise to interesting nanostructures that are only limited by our imagination. Over the past years, creative assembly of nucleic acids has fashioned a plethora of two-dimensional and three-dimensional nanostructures with precisely controlled size, shape and spatial functionalization. These nanostructures have been precisely patterned with molecules, proteins and gold nanoparticles for the observation of chemical reactions at the single molecule level, activation of enzymatic cascade and novel modality of photonic detection, respectively. Recently, they have also been engineered to encapsulate and release bioactive agents in a stimulus-responsive manner for therapeutic applications. The future of nucleic acid-based nanoengineering is bright and exciting. In this review, we will discuss the strategies to control the assembly of nucleic acids and highlight the recent efforts to build functional nucleic acid nanodevices for nanomedicine.

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“…An increasing range of nanomaterials is described [3], including targeted nanogenerators for radiotherapy [7] or even nanomachines such as “walking” DNA strands [8] or a DNA based DNA nanomotor [9], paving the way to a molecular robotics. While the latter may play a role in the future (e.g.…”

Section: Properties Of Nanoparticlesmentioning

confidence: 99%

Will Nanotechnology Influence Targeted Cancer Therapy?

Grimm

Scheinberg

2011

Seminars in Radiation Oncology

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The rapid development of techniques that enable synthesis (and manipulation) of matter on the nanometer scale, as well as the development of new nano-materials, will play a large role in disease diagnosis and treatment, specifically in targeted cancer therapy. Targeted nanocarriers are an intriguing means to selectively deliver high concentrations of cytotoxic agents or imaging labels directly to the cancer site. Often solubility issues and an unfavorable biodistribution can result in a suboptimal response of novel agents even though they are very potent. New nanoparticulate formulations allow simultaneous imaging and therapy (“theranostics”), which can provide a realistic means for the clinical implementation of such otherwise suboptimal formulations. In this review we will not attempt to provide a complete overview of the rapidly enlarging field of nanotechnology in cancer; rather, we will present properties specific to nanoparticles, and examples of their uses, which demonstrate their importance for targeted cancer therapy.

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A Rotational DNA Nanomotor Driven by an Externally Controlled Electric Field

Cited by 34 publications

References 38 publications

Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport

Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport

Nucleic acid-based nanoengineering: novel structures for biomedical applications

Will Nanotechnology Influence Targeted Cancer Therapy?

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