A Second Family with the Red Cell Antigen P^k

The Red Cell Antigen Pk and its Relationship to the P System: the Evidence of Three More P^k Families

“…and Pel. families (MATSON et al [9] and KORTEKANGAS et al [7]) contained the antibody II and so does the serum of all eight Pk members of the three families here reported. I n a freshly taken sample of serum the 17 is usually haemolytic but we find it more convenient t o use as an agglutinin: the agglutination reaction is stronger a t lower temperatures than a t 37°C.…”

“…If it be true that P k people have normal P, and P, genes then the first four possible genetic backgrounds for P k considered by MATSON et al [9] and by KORTEKANGAS et al [7] would be ruled out. These possibilities were: 1. that P k is a recessive character due to a gene allelic to P, and P,; 2. that P k is caused by a single gene able t o express itself only in the absence of the alleles P, and P, higher in series; 3. that P k is due t o interaction of two different alleles a t the P locus; 4. that P k results from the interaction of the gene Pk, allelic to P, and P,, with a gene a t another locus.…”

“…Of the 299 members of the three families, the cells of the eight Pk people alone failed to be agglutinated by 17 sera. It can be seen from the scores in the Appendix that the strength of reaction of 17 makes no distinction between P, and P, cells. [7]) but had no effect on the 17 of the Mys. family (MATSON et al [9]).…”

P1PK, Globoside, and FORS Blood Group Systems, Plus Some Other Related Blood Groups

“…These anti -P k react equally strongly with P 1 k and P 2 k cells [62,87] . Anti -P k is completely inhibited by HCF [3,65] . By inhibition of anti -P k with fractions of HCF prepared by partial acid hydrolysis, and with oligosaccharides of known structure, Watkins and Morgan [72] concluded that anti -P k was less demanding in its specifi city than anti -P1.…”

“…Red cells of parents and children of P k propositi were not agglutinated by anti -P k (separated from anti -P1PP k by adsorption with P 1 cells) and adsorption tests appeared to confi rm this lack of P k [65] . Red cells of parents and children of P k propositi were not agglutinated by anti -P k (separated from anti -P1PP k by adsorption with P 1 cells) and adsorption tests appeared to confi rm this lack of P k [65] .…”