A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone

Hsu, Ying-Pei; Li, Nan-Si; Chen, Ying-Tzu; Pang, Hao-Han; Wei, Kuo‐Chen; Yang, Hung-Wei

doi:10.1016/j.bios.2019.111960

Cited by 36 publications

(14 citation statements)

References 33 publications

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“…described an immunosensor for point‐of‐care testing of Zika virus (ZIKV) with a high sensitivity of 1 pg mL −1 in an instrument‐free manner ( Figure 6 a ). [ 90 ] In this accessory‐free system, the smartphone was used to photograph the colorimetric signal change, quantify the test results, and generate a graphical image of a surveillance map via a customized app, which simplified the instrumentation and improved infection management. Lateral flow immunoassay assays (LFIAS), the sample‐to‐answer POCT platforms, have been attracted much attention and widely used for the monitoring of virus disease outbreaks due to their cost‐effectiveness and simple operation.…”

Section: Smartphone‐based Point‐of‐care Testing For Virus Detectionmentioning

confidence: 99%

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Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

et al. 2022

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Infectious virus outbreaks pose a significant challenge to public healthcare systems. Early and accurate virus diagnosis is critical to prevent the spread of the virus, especially when no specific vaccine or effective medicine is available. In clinics, the most commonly used viral detection methods are molecular techniques that involve the measurement of nucleic acids or proteins biomarkers. However, most clinic‐based methods require complex infrastructure and expensive equipment, which are not suitable for low‐resource settings. Over the past years, smartphone‐based point‐of‐care testing (POCT) has rapidly emerged as a potential alternative to laboratory‐based clinical diagnosis. This review summarizes the latest development of virus detection. First, laboratory‐based and POCT‐based viral diagnostic techniques are compared, both of which rely on immunosensing and nucleic acid detection. Then, various smartphone‐based POCT diagnostic techniques, including optical biosensors, electrochemical biosensors, and other types of biosensors are discussed. Moreover, this review covers the development of smartphone‐based POCT diagnostics for various viruses including COVID‐19, Ebola, influenza, Zika, HIV, et al. Finally, the prospects and challenges of smartphone‐based POCT diagnostics are discussed. It is believed that this review will aid researchers better understand the current challenges and prospects for achieving the ultimate goal of containing disease‐causing viruses worldwide.

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Section: Smartphone‐based Point‐of‐care Testing For Virus Detectionmentioning

confidence: 99%

Section: Smartphone‐based Point‐of‐care Testing For Virus Detectionmentioning

confidence: 99%

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

et al. 2022

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“…Gold nanoparticles have been explored to detect mumps and zika virus (Hsu et al 2020;Long et al 2020). Gold nanozymes have been employed in rapid detection of SARS-CoV-19 (Pramanik et al 2021).…”

Section: Nanozymes For Detection Of Chemicals Viruses and Cellsmentioning

confidence: 99%

Nanozymes to fight the COVID-19 and future pandemics

et al. 2021

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In 2019, the pandemic induced by the rapid spread of the severe acute respiratory syndrome coronavirus-2 'SARS-CoV-2', also named coronavirus disease 'COVID-19', has rapidly caused serious health, economic, social, and political issues worldwide. This has been accentuated by asymptomatic carriers, fast viral mutations, incoherent lockdown policies, and limited methods of detection and treatment. Nucleic acid tests for COVID-19 are lengthy and complicated, and the rapid antibody tests produce false-negative diagnoses, particularly in the early stage of infection. Moreover, there are no specific and effective medicines available for treatment. Therefore, rapid diagnostics and therapeutics are urgently required. Here, we argue that nanozymesenzyme-mimicking nanoparticles-could be used for faster, more sensitive, and accurate detection and treatment of the COVID-19. Indeed, nanozymes have high surface areas allowing easier bioconjugation for detection, and nanozymes possess integrated drug-functionalization for treatment. Moreover, the size, composition, and surface chemistry of nanozymes can be rationally designed for improved theranostic applications. COVID-19 historyThe COVID-19 appeared in Wuhan, China, due to emergence of a novel strain of coronavirus (Sallard et al. 2021), which was provisionally named '2019-nCoV' by the World Health Organization (WHO). Later, the virus was renamed 'SARS-CoV-2' by the International Committee

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“…An advanced method with smartphone-enabled detection of the zika virus in the blood sample with an LOD of 1 pg/mL is developed using an antibody-modified spherical Pt−Au Core/ shell NPS 121.6 ± 10.7 nm in diameter (Figure 2). 94 Pt−Au Core/shell NPs synthesized by initially growing the core of AuNPs by chemical reduction method, followed by the growth of Pt NPs shell in the presence of L-ascorbic acid. Zika virus binds to the antibody-modified Pt−Au Core/shell NPs conjugated to the glass surface.…”

Section: Biosensing Using Aunpsmentioning

confidence: 99%

Delineating the Role of Tailored Gold Nanostructures at the Biointerface

Fatrekar

Morajkar

Krishnan

et al. 2021

ACS Appl. Bio Mater.

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Gold (Au) has emerged as a superior element, because of its widespread applications in electronic and medical fields. The desirable physical, chemical, optical, and inherent enzyme-like properties of Au are efficiently exploited for detection, diagnostic, and therapeutic purposes. Au offers a unique advantage of fabricating gold nanostructures (GNS) having exact physical, chemical, optical, and enzyme-like properties required for the specific biomedical application. In this Review, the emerging trend of GNS for various biomedical applications is highlighted. Some notable structural and chemical modifications achieved for the detection of biomolecules, pathogens, diagnosis of diseases, and therapeutic applications are discussed in brief. The limitations of GNS during biomedical usage are highlighted and the way forward to overcome these limitations are discussed.

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A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone

Cited by 36 publications

References 33 publications

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Nanozymes to fight the COVID-19 and future pandemics

Delineating the Role of Tailored Gold Nanostructures at the Biointerface

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