Delineating the Role of Tailored Gold Nanostructures at the Biointerface

Fatrekar, Adarsh P.; Morajkar, Rasmi; Krishnan, Saravanan; Dusane, Apurva; Madhyastha, Harishkumar; Vernekar, Amit A.

doi:10.1021/acsabm.1c00998

Cited by 17 publications

(11 citation statements)

References 179 publications

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“…Taken together, these studies indicate that the successful use of different types of metallic nanoparticles in biomedical applications demands modulation of their properties to maximize the antifungal effect and decrease its toxicity [ 106 ].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

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Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10–100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

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“…Au, Ag, and Cu NMs are known for their antipathogenic activity. Au NMs have been widely used due to their biocompatibility and functionalization aspects . Ag NPs possess excellent antimicrobial properties and are effective against biofilm-forming microbes.…”

Section: Nanomaterials and Their Antimicrobial Propertiesmentioning

confidence: 99%

“…Au NMs have been widely used due to their biocompatibility and functionalization aspects. 29 Ag NPs possess excellent antimicrobial properties and are effective against biofilm-forming microbes. Among several NPs, zinc oxide (ZnO) NPs have been shown to inhibit Staphylococcus aureus, while Ag NPs exert antimicrobial activity against Pseudomonas aeruginosa and Escherichia coli.…”

Section: Nanomaterials and Their Antimicrobial Propertiesmentioning

confidence: 99%

Nanotechnology-Based Solutions for Antibiofouling Applications: An Overview

Sinha

Kumar

Anand

et al. 2023

ACS Appl. Nano Mater.

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Biofouling is a serious concern and can cause health risks and financial burdens in many settings such as maritime structures, medical devices, and water treatment plants. Many technologies employing toxic biocides, antifouling toxic coatings, and chlorine have been established to prevent or impede biofouling. However, their applications are limited due to environmental and health concerns regarding biocides and coating materials. To overcome this, novel antifouling coatings employing ecofriendly, nontoxic nanomaterials and appreciable antimicrobial and antibiofilm properties have been developed. Due to intrinsic antimicrobial properties, these antifouling nanocoatings have been proven to be effective against several water-borne microorganisms. Various nanostructures of metals (silver, copper, and gold), metal oxides (zinc oxide, titanium oxide, copper oxide, and cerium oxide), carbon (graphene and carbon nanotubes), and metal nanocomposites inhibit the biocorrosion and biofilm formation caused by bacteria. Besides, antifouling technology developed based on nanocontainers releases key active substances that promote selfcleaning, anticorrosion, and antibiofilm properties. This review provides a comprehensive overview of nanotechnology-enabled antifouling agents developed to combat micro-and macrofouling phenomena. Moreover, the recent progress in the applications of antifouling coatings in industrial sectors such as marine (ships), water-treatment plants, and medical devices is elaborated with relevant examples. The mechanistic insights into the inhibitory action of bacterial cell growth and biofilm formation by antifouling nanocoatings are presented. The challenges associated with developing antifouling nanoproducts, their practical limitations, and prospects are also discussed.

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“…Bio and inert material assisted wound healing is a modern regenerative therapy aspect in the present day [ 3 , 4 ]. Various biomaterials for better wound management abilities have been attempted for better tissue growth [ 5 ]. Nano materials can be genuine curative materials for chronic wound complications.…”

Section: Introductionmentioning

confidence: 99%

Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFĸB Signaling Pathway

Madhyastha

Chakraborty

et al. 2023

IJMS

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Currently, there is a great demand for the development of nanomedicine aided wound tissue regeneration via silver doped nanoceuticals. Unfortunately, very little research is being carried out on antioxidants-doped silver nanometals and their interaction on the signaling axis during the bio-interface mechanism. In this study, c-phycocyanin primed silver nano hybrids (AgcPCNP) were prepared and analyzed for properties such as cytotoxicity, metal decay, nanoconjugate stability, size expansion, and antioxidant features. Fluctuations in the expression of marker genes during cell migration phenomena in in vitro wound healing scenarios were also validated. Studies revealed that physiologically relevant ionic solutions did not exhibit any adverse effects on the nanoconjugate stability. However, acidic, alkali, and ethanol solutions completely denatured the AgcPCNP conjugates. Signal transduction RT2PCR array demonstrated that genes associated with NFĸB- and PI3K-pathways were significantly (p < 0.5%) altered between AgcPCNP and AgNP groups. Specific inhibitors of NFĸB (Nfi) and PI3K (LY294002) pathways confirmed the involvement of NFĸB signaling axes. In vitro wound healing assay demonstrated that NFĸB pathway plays a prime role in the fibroblast cell migration. In conclusion, the present investigation revealed that surface functionalized AgcPCNP accelerated the fibroblast cell migration and can be further explored for wound healing biomedical applications.

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Delineating the Role of Tailored Gold Nanostructures at the Biointerface

Cited by 17 publications

References 179 publications

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Nanotechnology-Based Solutions for Antibiofouling Applications: An Overview

Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFĸB Signaling Pathway

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