A Simple Assay for Lipid Hydroperoxides in Serum or Plasma.

Yagi, Kazuichi; Komura, Sadaaki; Kayahara, Norihiko; Tatano, Toshio; Ohishi, Nobuko

doi:10.3164/jcbn.20.181

Cited by 29 publications

(25 citation statements)

References 19 publications

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“…In disease conditions, membrane damage often occurs in some organs or tissues; and such damage provokes lipid peroxidation in the membranes and accelerates the disorder in structure and functions of the membrane [34]. There is ample evidence that vitamin E protects biological membranes against lipid peroxidation in vivo [35].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

Gopalakrishnan

Murugesan

Babu

et al. 1996

J. Clin. Biochem. Nutr.

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SummaryCisplatin, an antitumor chemotherapeutic agent with doselimiting nephrotoxic side effects, was administered i.p, to male albino rats at a concentration of 6 mg/kg body wt. The antioxidant vitamin E (400 mg/kg body wt., orally) and the diuretic acetazolamide (ACZ) (20 mg/ kg body wt., i.p.) were co-administered as modulators. The effect of cisplatin on lipid peroxidation and antioxidant enzyme levels was then examined. The agent increased the level of lipid peroxidation and significantly decreased the activities of antioxidant enzymes. These effects may have been due to the formation of free radicals and were considered to be one of the reasons for cisplatin-induced nephrotoxicity. Interestingly, these changes were found to be very much counteracted by vitamin E and acetazolamide when they were co-administered along with the cisplatin. Hence, we suggest that co-administration of vitamin E and acetazolamide along with cisplatin will be clinically advantageous in attenuating cisplatin-induced nephrotoxicity during chemotherapy. Cisplatin (cis-diammine dichloro platinum-II), a platinum containing coordination complex, is an antitumor agent with proven efficacy as a single agent against a wide spectrum of malignancies [1]. Toxicological studies in humans and animals indicate that higher doses produce enzyme inhibition and histological changes in liver, kidney, gastrointestinal tract, and bone marrow [2]. However, the chief dose-limiting side effect of cisplatin is its pronounced nephrotoxicity, which occurs at doses lower than those that damage other organs [3]. The underlying molecular mechanism of the nephrotoxicity induced by cisplatin remains unclear

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Section: Discussionmentioning

confidence: 99%

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

Gopalakrishnan

Murugesan

Babu

et al. 1996

J. Clin. Biochem. Nutr.

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“…glutathione peroxidase (GPX) [19], glutathione-S-transferase (GST) [20], lipid peroxidation [21], and glutathione [22]. Serum levels of lipid peroxides (LPO) [23], glutathione (GSH), iron [24], and ceruloplasmin [25] were also assayed.…”

Section: Methodsmentioning

confidence: 99%

Effect of Fish Oil on Myocardial Antioxidant Defense in Isoproterenol-Induced Myocardial Infarction.

Viswanadha

Srinivasulu

2000

J. Clin. Biochem. Nutr.

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“…Tissue and serum lipid peroxidation was evaluated by measurement of thiobarbituric acid reactive substance (Ohkawa et al, 1975;Yagi, 1976). Malondialdehyde has been identified as the product of lipid peroxidation, which reacts with thiobarbituric acid resulting into chromogen, this chromogen extracted from organic solvent and absorbency of organic phase is determined at 532 nm.…”

Section: Assay Of Lipid Peroxidasementioning

confidence: 99%

Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats

Mudagal¹

2011

Afr. J. Pharm. Pharmacol.

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A Simple Assay for Lipid Hydroperoxides in Serum or Plasma.

Cited by 29 publications

References 19 publications

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

Effect of Fish Oil on Myocardial Antioxidant Defense in Isoproterenol-Induced Myocardial Infarction.

Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats

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