A simple method of isolation of chloramphenicol in honey and its estimation by liquid chromatography coupled to electrospray ionization tandem mass spectrometry

Kannan, Vivekanandan; Swamy, Madugundu Guru; Prasad, Sudhanand; Mukherjee, Rama

doi:10.1002/rcm.2169

Cited by 33 publications

(14 citation statements)

References 20 publications

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“…Several reports have described estimation of CAP by liquid chromatography-tandem mass spectrometry (LC/MS/MS) in shrimp (Neuhaus et al, 2002;Rønning et al, 2006), meat (Bogusz et al, 2004;Cooper et al, 1998;Li et al, 2002;Mottier et al, 2003;Rønning et al, 2006), milk (Guy et al, 2004;Huang et al, 2006;Rønning et al, 2006), and honey (Ashwin et al, 2005;Forti et al, 2005;Huang et al, 2006;Ortelli et al, 2004;Rønning et al, 2006;Turnipseed et al, 2002;Vanhoenacker et al, 2003;Verzegnassi et al, 2003;Vivekanandan et al, 2005).…”

Section: Introductionmentioning

confidence: 97%

Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market

Bononi

Tateo

2008

Journal of Food Composition and Analysis

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Section: Introductionmentioning

confidence: 97%

Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market

Bononi

Tateo

2008

Journal of Food Composition and Analysis

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“…Some methods describe direct extraction and clean-up of chloramphenicol from honey with C 18 SPE (Bogusz et al, 2004) or use of C 18 SPE for further clean-up of an ethyl acetate extract (Ortelli et al, 2004) or of a dichloromethane/acetone extract (Forti et al, 2005) of the honey samples. Other methods involve use of supported liquid-liquid extraction (LLE) on diatomaceous earth cartridges (Kaufmann and Butcher, 2005;Vivekanandan et al, 2005), MIP (Shi et al, 2010) and IAC (Mackie et al, 2013) techniques.…”

Section: Confirmatory Methodsmentioning

confidence: 99%

“…Three samples contained more than 2 µg/kg and six samples contained between 0.3 and 1.7 µg/kg (Vivekanandan et al, 2005 In Romania, 12 honey samples (year of collection not reported) collected from beekeepers in Romania were analysed by LC-MS (LOD/LOQ = 0.13/0.27 µg/kg) and chloramphenicol was detected in one sample (1.4 µg/kg) (Mǎrghitaş et al, 2010). In addition, Simion et al (2011) analysed 82 honey samples, collected from beekeepers, using ELISA (LOD/LOQ/CCα/CCβ not reported).…”

Section: Occurrence In Food Of Animal Originmentioning

confidence: 99%

Scientific Opinion on Chloramphenicol in food and feed

2014

EFS2

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Chloramphenicol is an antibiotic not authorised for use in food-producing animals in the European Union (EU). However, being produced by soil bacteria, it may occur in plants. The European Commission asked EFSA for a scientific opinion on the risks to human and animal health related to the presence of chloramphenicol in food and feed and whether a reference point for action (RPA) of 0.3 µg/kg is adequate to protect public and animal health. Data on occurrence of chloramphenicol in food extracted from the national residue monitoring plan results and from the Rapid Alert System for Food and Feed (RASFF) were too limited to carry out a reliable human dietary exposure assessment. Instead, human dietary exposure was calculated for a scenario in which chloramphenicol is present at 0.3 µg/kg in all foods of animal origin, foods containing enzyme preparations and foods which may be contaminated naturally. The mean chronic dietary exposure for this worst-case scenario would range from 11 to 17 and 2.2 to 4.0 ng/kg b.w. per day for toddlers and adults, respectively. The potential dietary exposure of livestock to chloramphenicol was estimated to be below 1 µg/kg b.w. per day. Chloramphenicol is implicated in the generation of aplastic anaemia in humans and causes reproductive/hepatotoxic effects in animals. Margins of exposure for these effects were calculated at 2.4 × 10 5 or greater and the CONTAM Panel concluded that it is unlikely that exposure to food contaminated with chloramphenicol at or below 0.3 µg/kg is a health concern for aplastic anaemia or reproductive/hepatotoxic effects. Chloramphenicol exhibits genotoxicity but, owing to the lack of data, the risk of carcinogenicity cannot be assessed. The SUMMARYChloramphenicol is a broad-spectrum antibiotic effective against Gram-positive and Gram-negative bacteria and, in the past, has been widely used to treat infections in both humans and animals. Chloramphenicol is not authorised for use in food-producing animals in the European Union (EU) but may be used in human medicine and in treatments for non-food-producing animals. Apart from its potential occurrence as a residue in food from illicit treatment of food-producing animals, chloramphenicol has also been used in feed and food enzyme products and may occur naturally in plants from its production by the soil bacterium Streptomyces venezuelae.The EFSA Scientific Opinion entitled "Guidance on methodological principles and scientific methods to be taken into account when establishing Reference Points for Action (RPAs) for non-allowed pharmacologically active substances present in food of animal origin" identified an approach for establishing RPAs for various categories of non-allowed pharmacologically active substances. However, the opinion also identified certain categories of non-allowed pharmacologically active substances that are considered to be outside the scope of the procedure, including substances causing blood dyscrasias (aplastic anaemia) such as chloramphenicol. As chloramphenicol is excluded fro...

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“…Chloramphenicol (CAP) is a broad spectrum antibiotic derived from the soil bacterium Streptomyces, ubiquitously used for treating bacterial diseases in veterinary and aquaculture practice [1]. However, it has the potential to cause serious toxic effects on humans and animals when given by mouth or injection, with non-target effects such as bone marrow depression, aplastic anemia, hypoplastic anemia, thrombocytopenia, as well as granulocytopenia [2].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods

Shi

Zheng

et al. 2007

Journal of Chromatography B

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A simple method of isolation of chloramphenicol in honey and its estimation by liquid chromatography coupled to electrospray ionization tandem mass spectrometry

Cited by 33 publications

References 20 publications

Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market

Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market

Scientific Opinion on Chloramphenicol in food and feed

Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods

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