2008
DOI: 10.1080/02841860802256426
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A simulation of MRI based dose calculations on the basis of radiotherapy planning CT images

Abstract: A systematic study using segmented MR images was undertaken. To achieve an acceptable accuracy in the CTV dose, the MR images should be segmented into bone and water equivalent tissue. Still, significant dose deviation for the organs at risk may be present. As tissue segmentation in real MR images is introduced, segmentation errors and errors that stem from geometrical non-linearities may further reduce the accuracy.

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Cited by 66 publications
(67 citation statements)
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“…Some methods model the physical properties of the imaging process, e.g., to derive intrinsic tissue parameters from MRI scans [2] or to derive pseudo-CT from MRI in radiotherapy applications [3,4]. But an explicit model of the imaging process is not even required, as image processing techniques can be sufficient: for example, pseudo-CT images have also been made with tissue segmentation [5,6], with Gaussian mixture models [7] or by registering and combining CT images [8,9]. Interestingly, data synthesis can not only generate images but also helps as an intermediate step.…”
Section: Introductionmentioning
confidence: 99%
“…Some methods model the physical properties of the imaging process, e.g., to derive intrinsic tissue parameters from MRI scans [2] or to derive pseudo-CT from MRI in radiotherapy applications [3,4]. But an explicit model of the imaging process is not even required, as image processing techniques can be sufficient: for example, pseudo-CT images have also been made with tissue segmentation [5,6], with Gaussian mixture models [7] or by registering and combining CT images [8,9]. Interestingly, data synthesis can not only generate images but also helps as an intermediate step.…”
Section: Introductionmentioning
confidence: 99%
“…However, as no fundamental relationship between MR image intensities and electron density values exists [6], an accurate method to derive CT equivalent information from MR data (referred to as synthetic CT) is required to perform dose calculations. To assess the feasibility of MR-based treatment planning, the first experiments consisted of assigning single bulk densities to tissue classes (such as bone, air and soft-tissue) delineated either from a CT image [7], [8], [9] or manually from an MR image [10], and then comparing the resulting synthetic CT-based plan to the original CT-based plan. For both H&N and prostate target volumes, dosimetric errors were reported to be 1–2% different from the CT-based dose calculation [8], [9], [10].…”
Section: Introductionmentioning
confidence: 99%
“…There is no relation between MR image values and electron density as is the case for CT. One possible way to overcome this is to ignore the variations in electron density in the patient, i.e., turn off the inhomogeneity correction. Using this approach to calculate doses, several groups have noted dose differences ranging from 0.9% to 2.5% [10,22,23]. For brain treatments, the difference in dose with and without inhomogeneity correction has been reported to be in the range 1-1.5% [13,24].…”
Section: Introductionmentioning
confidence: 99%