A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice

Moretti, Morgana; Werle, Isabel; Rosa, Priscila B.; Neis, Vivian B.; Platt, Nicolle; Souza, Suene Vanessa da Silva; Rodrigues, Ana Lúcia S.

doi:10.1016/j.pbb.2019.172800

Cited by 16 publications

(6 citation statements)

References 54 publications

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“…The treatment of metformin combined with AA was shown to down‐regulate glucose, immobility period, and corticosterone levels, up‐regulate the insulin and monoamine levels and decrease pro‐inflammatory cytokines as well as oxidative stress in diabetic rats with comorbid depression 209 (Table 1). Also, in CUS‐induced rats, AA and ketamine in single sub‐effective doses have alleviated depressive‐like behavior 210 . Ascorbic acid not only ameliorated 24 h as well as postprandial glycemia but also down‐regulated blood pressure in T2DM 211 .…”

Section: Treatmentmentioning

confidence: 95%

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

Li,

Yang,

Zhou

et al. 2023

CNS Neurosci Ther

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BackgroundThe comorbidity between diabetes mellitus and depression was revealed, and diabetes mellitus increased the prevalence of depressive disorder, which ranked 13th in the leading causes of disability‐adjusted life‐years. Insulin resistance, which is common in diabetes mellitus, has increased the risk of depressive symptoms in both humans and animals. However, the mechanisms behind the comorbidity are multi‐factorial and complicated. There is still no causal chain to explain the comorbidity exactly. Moreover, Selective serotonin reuptake inhibitors, insulin and metformin, which are recommended for treating diabetes mellitus‐induced depression, were found to be a risk factor in some complications of diabetes.AimsGiven these problems, many researchers made remarkable efforts to analyze diabetes complicating depression from different aspects, including insulin resistance, stress and Hypothalamic–Pituitary–Adrenal axis, neurological system, oxidative stress, and inflammation. Drug therapy, such as Hydrogen Sulfide, Cannabidiol, Ascorbic Acid and Hesperidin, are conducive to alleviating diabetes mellitus and depression. Here, we reviewed the exact pathophysiology underlying the comorbidity between depressive disorder and diabetes mellitus and drug therapy.MethodsThe review refers to the available literature in PubMed and Web of Science, searching critical terms related to diabetes mellitus, depression and drug therapy.ResultsIn this review, we found that brain structure and function, neurogenesis, brain‐derived neurotrophic factor and glucose and lipid metabolism were involved in the pathophysiology of the comorbidity. Obesity might lead to diabetes mellitus and depression through reduced adiponectin and increased leptin and resistin. In addition, drug therapy displayed in this review could expand the region of potential therapy.ConclusionsThe review summarizes the mechanisms underlying the comorbidity. It also overviews drug therapy with anti‐diabetic and anti‐depressant effects.

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Section: Treatmentmentioning

confidence: 95%

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

Li,

Yang,

Zhou

et al. 2023

CNS Neurosci Ther

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“…field tests were conducted for all animals, and significant differences between control and model groups (p < 0:05) were considered to show the successful establishment of the model [23].…”

Section: Behavioral Testing the Sucrose Preference And Openmentioning

confidence: 99%

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

Zhao

Yan

et al. 2023

Andrologia

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The impact of depression on spermatogenic function and protein expression was investigated by reference to a bioinformatics database for the prediction of key targets and pathways. Experimental validation was performed using a rat model established using the chronic restraint stress method. Organ coefficients and semen parameters were measured. Hematoxylin and eosin (HE) staining was performed to compare testicular tissue between model and control rats. Western blotting and RT–qPCR were conducted to evaluate protein and mRNA expression. As a result, depression and male infertility (MI) were found to share 81 common targets, and the PI3K/Akt/FOXO1 signaling pathway was involved in both conditions. Animal experiments showed testis and epididymis coefficients to be lower in the model group. HE staining showed damage to the seminiferous tubules of model rats. PI3K and p-Akt mRNA and protein were present at lower levels and FOXO1 at higher levels in the model group. Depression led to reduced spermatogenic function in rats and might be associated with differential expression of the PI3K/Akt/FOXO1 signaling pathway.

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“…In addition, ASC has also been linked to the modulation of the Gamma amino-butyric acid receptor subunit A (GABA A ) receptor and subsequent potentiation of GABA A -mediated signaling in the CNS [ 198 , 199 ]. A role of ASC in ameliorating GABA and NMDA receptor dysregulation in depression has been suggested [ 199 , 200 ]. Though vitC deficiency may well be a factor in depression, clinical studies are few and often differ significantly in experimental design, analytical methodology and outcome measures, limiting comparison.…”

Section: Vitamin C Functions In the Brainmentioning

confidence: 99%

Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models

Tveden‐Nyborg

2021

Nutrients

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Severe and long-term vitamin C deficiency can lead to fatal scurvy, which is fortunately considered rare today. However, a moderate state of vitamin C (vitC) deficiency (hypovitaminosis C)—defined as a plasma concentration below 23 μM—is estimated to affect up to 10% of the population in the Western world, albeit clinical hallmarks in addition to scurvy have not been linked to vitC deficiency. The brain maintains a high vitC content and uniquely high levels during deficiency, supporting vitC’s importance in the brain. Actions include both antioxidant and co-factor functions, rendering vitamin C deficiency likely to affect several targets in the brain, and it could be particularly significant during development where a high cellular metabolism and an immature antioxidant system might increase sensitivity. However, investigations of a non-scorbutic state of vitC deficiency and effects on the developing young brain are scarce. This narrative review provides a comprehensive overview of the complex mechanisms that regulate vitC homeostasis in vivo and in the brain in particular. Functions of vitC in the brain and the potential consequences of deficiency during brain development are highlighted, based primarily on findings from experimental animal models. Perspectives for future investigations of vitC are outlined.

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A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice

Cited by 16 publications

References 54 publications

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models

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