A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain

Abstract

A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain. , 37: 190-196 Neurotoxicology AbstractPerfluorohexane sulfonate (PFHxS) is an industrial chemical and belongs to the group of perfluorinated compounds (PFCs). It has recently been shown to cause developmental neurobehavioral defects in mammals. These compounds are commonly used in products such as surfactant and protective coating due to their ability to repel water-and oil stains. PFCs are globally found in the environment as well as in human umbilical cord blood, serum and breast milk. In a previous study on other well-known PFCs i.e. PFOS and PFOA, it was shown that neonatal exposure caused altered neuroprotein levels in the hippocampus and cerebral cortex in neonatal male mice. The present study show that neonatal exposure to PFHxS, during the peak of the brain growth spurt, can alter neuroprotein levels e.g. CaMKII, GAP-43, synaptophysin and tau, which are essential for normal brain development in mice. This was measured for both males and females, in hippocampus and cerebral cortex. The results suggest that PFHxS may act as a developmental neurotoxicant and the effects are similar to that of PFOS and PFOA, but also to other substances such as PCBs, PBDEs and Bisphenol A.

Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003–2013

“…It is also consistent with our individual-level finding that some of the participants had a large positive mean change score for PFHxS between visits. The hazards of PFHxS could include developmental neurotoxicity (Lee and Viberg, 2013) or endocrine-disrupting potential (Kjeldsen and Bonefeld-Jorgensen, 2013; Long et al, 2013; Wen et al, 2013), so it is important to determine whether there is a new source of PFHxS exposure and to further characterize this compound’s relevance for human health. The possible change in trajectory of PFHxS suggested at the population level but not corroborated by most individual trajectories could also be a result of aggregation bias.…”

Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin

“…The BGS have shown to be sensitive to toxic insults by xenobiotics such as polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), perfluorinated compounds (PFCs), pharmaceuticals, nicotine and bisphenol A (Eriksson, 1998;Eriksson et al, 2000;Johansson et al, 2008Johansson et al, , 2009Lee and Viberg, 2013;Viberg et al, 2006Viberg et al, , 2008bViberg et al, , 2011Viberg et al, , 2013Viberg et al, , 2014Viberg and Lee, 2012); and we have previously seen that certain of these xenobiotics affect the level of neuroprotein expression when exposed during this critical phase. Also, previous studies on pyrethroids and organochlorines have shown to cause developmental neurotoxicity in mice, manifested as deranged spontaneous behavior and changes in muscarinic acetylcholine receptor density in the brain, when neonatally exposed (Ahlbom et al, 1994;Eriksson et al, 1992Eriksson et al, , 1993Talts et al, 1998).…”

Biomonitoring and Elimination of Perfluorinated Compounds and Polychlorinated Biphenyls through Perspiration: Blood, Urine, and Sweat Study

“…In addition, animal and human studies have now linked PFC exposure with developmental toxicity [27], neurotoxicity [28], reproductive toxicity [29], cardiovascular toxicity [26], metabolic dysregulation [30], development of arthritis [31], carcinogenesis [32], and immunotoxicity [33]. There has been minimal research exploring strategies to eliminate PFCs [34].…”