A single nucleotide polymorphism in the promoter region (rs10877887) of let-7 is associated with hepatocellular carcinoma in a Chinese population

Abstract

ABSTRACT. Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter region of the let-7 family (rs10877887) and the susceptibility and prognosis of HCC, using a case-control research model. Eighty-nine HCC patients and 95 healthy controls were genotypes by direct sequencing, and the correlation between rs10877887 genotypes and HCC susceptibility was evaluated using an unconditional logistic regression model. Populations with the CT + CC genotype were at a significantly higher risk of HCC compared to those with the TT genotype (CT + CC vs TT: odds ratio = 3.52, 95% confidence interval = 1.90-6.52; P < 0.05). Furthermore, we discovered that the genetic variant of rs10877887 might serve as a prognostic marker for survival in HCC patients, as the CT + CC genotype was associated with poor prognosis.

Polymorphism in the Promoter Region of Let-7 and Response to Doxorubicin Treatment in Egyptian Hepatocellular Carcinoma

“…Our results came in agreement with a study done by Huang et al, 15 who reported that the polymorphism in the rs 10877887 showed no statistical significance with susceptibility to HCC in Chinese population. This study itself -like our study-came in contrast with a study done by Sui et al, 16 on the same Chinese population and reported that SNP in the rs10877887 in the promoter region of Let-7 are significantly associated with high risk to HCC compared to those with the wild TT type. Another study done by Xie et al, 17 found that hepatocellular carcinoma patients carrying the C allele of rs10877887 in the promotor region of let-7i had a significantly increased death risk compared to patients with the TT genotype.…”

A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women

“…However, we did not find any difference of rs10877887 between cases and controls. Inconsistent with our result, SNP rs10877887 CT/CC genotypes were reported to be a risk factor for lung cancer [15] and hepatocellular carcinoma [20]. In contrast, a reduced risk of rs10877887 CT/CC genotypes was reported in patients with papillary thyroid carcinoma [12].…”

“…Both the SNPs were predicted to influence the binding affinity with transcription factors [13]. Given the potential function, the two SNPs were widely investigated in numerous human diseases, including papillary thyroid carcinoma [12], lung cancer [15], hepatocellular carcinoma [20], intracranial aneurysm [33], major depressive disorder [34], and ischemic stroke [35]. However, the relationship between the two SNPs with BC remains unclear.…”

Genetic polymorphisms of miRNA let7a‐2 and pri‐mir‐34b/c are associated with an increased risk of papillary thyroid carcinoma and clinical/pathological features

“…Wang et al demonstrated that the let7a‐2 rs10877887 polymorphism might be associated with a lower risk of PTC and the rs13293512 polymorphism could be correlated with lymph node metastasis in patients with PTC . In addition, several reports have described the association between let‐7 family polymorphisms and different cancers, such as head and neck cancer, hepatocellular carcinoma, and lung cancer …”