A spatial and temporal analysis of dorsal root and sympathetic ganglion formation in the avian embryo

Lallier, Thomas E.; Bronner‐Fraser, Marianne

doi:10.1016/0012-1606(88)90192-3

Cited by 105 publications

(59 citation statements)

References 36 publications

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“…At mid-to late-migratory stages, N-cadherin was prominent in the neural tube, notochord, and myotome, but absent from migrating neural crest cells, as shown in the stage 18 embryo illustrated in Figure 4. As documented previously (Thiery et al, 1982;Duband et al, 1985;Lallier and Bronner-Fraser, 1988), N-CAM has a similar distribution pattern to that of N-cadherin at this stage.…”

Section: Distribution Of N-cam and N-cadherin During Early Stages Of supporting

confidence: 85%

“…In the case of N-CAM, a careful study of immunoreactivity during ganglion formation showed that it appears in dorsal root ganglia (DRG) several stages after gangliogenesis, making a direct role for N-CAM in ganglionic condensation unlikely (Duband et al, 1985;Lallier and Bronner-Fraser, 1988). Here, we describe the distribution of N-CAM and N-cadherin during the initiation of trunk neural crest migration and the condensation of the dorsal root and sympathetic ganglia.…”

Section: Introductionmentioning

confidence: 93%

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Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration

Akitaya

Bronner‐Fraser

1992

Developmental Dynamics

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173

115

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Because of their distribution and known ability to promote neuronal adhesion, it has been proposed that N-CAM and N-cadherin are involved in the formation of the nervous system. Here, we examine the expression of these molecules during the initiation and cessation of trunk neural crest cell migration during the formation of the peripheral nervous system. Whereas other neural tube cells express N-cadherin, the dorsal neural tube containing neural crest precursors has little or no N-cadherin immunoreactivity. In contrast, N-CAM is expressed in the dorsal neural tube and on early migrating neural crest cells, from which it gradually disappears during migration. Both N-CAM and N-cadherin are absent from neural crest cells at advanced stages of migration. As neural crest cells cease migration and condense to form dorsal root and sympathetic ganglia, N-cadherin but not N-CAM is observed on the forming ganglia, identified by neurofilament expression and the aggregation of HNK-1 reactive cells. The results demonstrate that the absence of N-cadherin correlates with the onset of neural crest migration and its reappearance correlates with cessation of migration and precedes gangliogenesis. 0 1992 Wiley-Liss, Inc.

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Section: Distribution Of N-cam and N-cadherin During Early Stages Of supporting

confidence: 85%

Section: Introductionmentioning

confidence: 93%

Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration

Akitaya

Bronner‐Fraser

1992

Developmental Dynamics

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173

115

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“…Molecular analyses have confirmed that complementary expression of ephrinB1 (on the caudal half of somites) and its receptor EphB2 (on trunk neural crest cells) mediate neural crest cell-substrate interactions that sculpt chick trunk neural crest cells into discrete migratory streams (Wang and Anderson, 1997;Krull et al, 1997). As each discrete trunk neural crest cell migratory stream terminates ventral to a rostral half-somite, there has been speculation that sympathetic ganglion formation is the direct result of the iterated neural crest cell migratory stream pattern imposed by the somite (Bronner-Fraser, 1986;Lallier and Bronner-Fraser, 1988;Oakley and Tosney, 1993).…”

Section: Introductionmentioning

confidence: 89%

Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia

et al. 2006

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Previous studies have suggested that the segmental pattern of neural-crest-derived sympathetic ganglia arises as a direct result of signals that restrict neural crest cell migratory streams through rostral somite halves. We recently showed that the spatiotemporal pattern of chick sympathetic ganglia formation is a two-phase process. Neural crest cells migrate laterally to the dorsal aorta, then surprisingly spread out in the longitudinal direction, before sorting into discrete ganglia. Here, we investigate the function of two families of molecules that are thought to regulate cell sorting and aggregation. By blocking Eph/ephrins or N-cadherin function, we measure changes in neural crest cell migratory behaviors that lead to alterations in sympathetic ganglia formation using a recently developed sagittal slice explant culture and 3D confocal time-lapse imaging. Our results demonstrate that local inhibitory interactions within inter-ganglionic regions, mediated by Eph/ephrins, and adhesive cell-cell contacts at ganglia sites, mediated by N-cadherin, coordinate to sculpt discrete sympathetic ganglia.

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“…DRG derive from migrating neural crest cells that coalesce laterally to the neural tube beginning at ϳ Embryonic Day 2.75-3 in the chick (E2.75-E3; Teillet et al, 1987;Lallier and Bronner-Fraser, 1988). Neurogenesis in the nascent DRG then ensues, peaking at ϳE4.5-E5, which is followed by target innervation and programmed cell death of postmitotic neurons between ϳE5 and E12, peaking between E7 and E9 (Carr and Simpson, 1978).…”

Section: Resultsmentioning

confidence: 99%

“…An excellent system within the PNS in which to address this question is the dorsal root ganglion (DRG), one of the major derivatives of the neural crest (Teillet et al, 1987;Lallier and Bronner-Fraser, 1988). Much is known about the biology of mature DRG: once sensory neurons differentiate, they innervate discrete central and peripheral targets, become dependent on particular neurotrophins for survival and undergo an extensive period of target-regulated programmed cell death resulting in the generation of approximately 20 distinct subclasses of sensory neurons and two types of glial cells (Scott, 1992;Lindsay, 1996;Snider and SilosSantiago, 1996).…”

Section: Introductionmentioning

confidence: 99%

Identification of genes regulating sensory neuron genesis and differentiation in the avian dorsal root ganglia

Nelson

Sadhu

Kasemeier

et al. 2004

Developmental Dynamics

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The dorsal root ganglia (DRG) derive from a population of migrating neural crest cells that coalesce laterally to the neural tube. As the DRG matures, discrete cell types emerge from a pool of differentiating progenitor cells. To identify genes that regulate sensory genesis and differentiation, we have designed screens to identify members from families of known regulatory molecules such as receptor tyrosine kinases, and generated full-length and subtractive cDNA libraries between immature and mature DRG for identifying novel genes not previously implicated in DRG development. Several genes were identified in these analyses that belong to important regulatory gene families. Quantitative PCR confirmed differential expression of candidate cDNAs identified from the subtraction/differential screening. In situ hybridization further validated dynamic expression of several cDNAs identified in our screens. Our results demonstrate the utility of combining specific and general screening approaches for isolating key regulatory genes involved in the genesis and differentiation of discrete cell types and tissues within the classic embryonic chick model system. Developmental Dynamics 229:618 -629, 2004.

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A spatial and temporal analysis of dorsal root and sympathetic ganglion formation in the avian embryo

Cited by 105 publications

References 36 publications

Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration

Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration

Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia

Identification of genes regulating sensory neuron genesis and differentiation in the avian dorsal root ganglia

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