A strategy for the discovery and validation of toxicity quality marker of Chinese medicine based on network toxicology

Li, Yubo; Zhang, Yani; Wang, Yuming; Li, Yamei; Yang, Feifan; Zhang, Pengjie; Zhang, Yanjun; Liu, Changxiao

doi:10.1016/j.phymed.2018.01.018

Cited by 27 publications

(14 citation statements)

References 26 publications

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“…In terms of quality control, the information about the cultivation environment, cultivars, processing, transportation, storage time, and quantitative studies of the index components are scarcely in the existing studies. It is worth noting that the dual quality control, chemical benchmark and effect benchmark has been generally accepted (Li et al, 2019;Zhu et al, 2019). Therefore, the quality standard of it could be supported by the effect benchmark.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang

Zhao

et al. 2021

Front. Pharmacol.

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K. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In addition, it has been used widely as spices since its highly aromas. The aim of this review is to compile and update the current progresses of ethnomedicinal uses, phytochemistry, pharmacology and toxicology of K. galanga. All the data on K. galanga were based on different classical literary works, multiple electronic databases including SciFinder, Web of Science, PubMed, etc. The results showed that ninety-seven compounds have been identified from rhizome of K. galanga, including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids and esters. Modern pharmacology studies revealed that extracts or secondary metabolites of the herb possessed anti-inflammatory, anti-oxidant, anti-tumorous, anti-bacterial, and anti-angiogenesis effects, which were closely related to its abundant ethnomedicinal uses. In conclusion, although previous research works have provided various information of K. galanga, more in-depth studies are still necessary to systemically evaluate phytochemistry, pharmacological activities, toxicity and quality control of this herb.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang

Zhao

et al. 2021

Front. Pharmacol.

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“…18 Compared with the traditional toxicological methods, which are time-consuming and less comprehensively researched, the network toxicology illustrates the interaction between compounds and the body from the overall perspective of biological networks, and explains the mechanisms of the adverse reactions of compounds. 18 However, the current network toxicology only considers molecular targets without mentioning the occurrence and development of diseases, so it lacks the systematic characteristics of disease development. 19−22 Given the incompleteness of the interactome and the limited knowledge of hepatotoxicity disease-associated genes, it is not obvious if the available data has sufficient coverage to map out modules associated with liver injury disease.…”

Section: Introductionmentioning

confidence: 99%

Probing the Mechanism of Hepatotoxicity of Hexabromocyclododecanes through Toxicological Network Analysis

Dai

Tang

Dai

et al. 2020

Environ. Sci. Technol.

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The prediction and mechanism analysis of hepatotoxicity of contaminants, because of their various phenotypes and complex mechanisms, is still a key problem in environmental research. We applied a toxicological network analysis method to predict the hepatotoxicity of three hexabromocyclododecane (HBCD) diastereoisomers (α-HBCD, β-HBCD, and γ-HBCD) and explore their potential mechanisms. First, we collected the hepatotoxicity related genes and found that those genes were significantly localized in the human interactome. Therefore, these genes form a disease module of hepatotoxicity. We also collected targets of α-, β-, and γ-HBCD and found that their targets overlap with the hepatotoxicity disease module. Then, we trained a model to predict hepatotoxicity of three HBCD diastereoisomers based on the relationship between the hepatotoxicity disease module and targets of compounds. We found that 593 genes were significantly located in the hepatotoxicity disease module (Z = 11.9, p < 0.001) involved in oxidative stress, cellular immunity, and proliferation, and the accuracy of hepatotoxicity prediction of HBCD was 0.7095 ± 0.0193 and the recall score was 0.8355 ± 0.0352. HBCD mainly affects the core disease module genes to mediate the adenosine monophosphate-activated kinase, p38MAPK, PI3K/Akt, and TNFα pathways to regulate the immune reaction and inflammation. HBCD also induces the secretion of IL6 and STAT3 to lead hepatotoxicity by regulating NR3C1. This approach is transferable to other toxicity research studies of environmental pollutants.

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“…The two most commonly processed forms of PAR in clinical applications are wine‐baked Paeoniae Alba Radix (WPAR) and vinegar‐baked Paeoniae Alba Radix (VPAR). According to some studies (Li et al, ), the acidity and coldness are reduced in WPAR, and it is especially useful for postpartum abdominal pain. VPAR exhibits a greater potential activity of relieving depressed liver effects.…”

Section: Introductionmentioning

confidence: 99%

“…VPAR exhibits a greater potential activity of relieving depressed liver effects. The clinical efficacies of the RPAR and two processed products are different, which may be due to differences in the contents of some compounds (Li et al, ). Modern phytochemical studies have suggested that the major bioactive components of PAR are monoterpene glycosides (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, much attention has been paid to the study of quantitative quality markers (Q‐markers). Q‐markers not only exist naturally in the raw or processed TCM and are closely associated with their efficacy or safety, but are also closely related to the functional attributes of the TCM (Guo, ; Li et al, ; Liu et al, ; Zhong et al, ). Therefore, we speculate that paeoniflorin, albiflorin, benzoyl paeoniflorin, oxypaeoniflorin, gallic acid and benzoic acid are Q‐markers in PAR.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis of different batches of raw, wine‐processed, and vinegar‐processed Paeoniae Alba Radix using ultra‐performance convergence chromatography coupled with photo diode array detection

Liu

Jiang

Guo

et al. 2019

Biomedical Chromatography

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Supercritical fluid chromatography is a safe and ecofriendly analytical technique that has not been fully applied to the analysis of traditional Chinese medicine. This is the first study on the separation of six quality markers-paeoniflorin, albiflorin, benzoyl paeoniflorin, oxypaeoniflorin, gallic acid and benzoic acid-from raw, wine-baked and vinegar-baked Paeoniae Alba Radix (PAR) by Supercritical fluid chromatography.Optimum separation was achieved on an HSS C 18 SB column (100 × 3.0 mm, 1.8 μm particles) with a gradient elution of high-purity carbon dioxide as mobile phase A and methanol-acetonitrile (70:30, v/v) with 0.10% phosphoric acid as mobile phase B. The flow rate was set at 0.7 mL/min for 15.0 min. The method was validated in terms of the overall intraday and interday precision, with relative standard deviations (RSDs) of 0.87-2.87 and 1.47-3.63%, respectively. The recoveries were 98.10-103.60% with an RSD of 1.00-3.40%. The stability of the RSD values was in the range 1.10-3.78%. The developed approach was successfully applied and provides a valuable reference for the quality assessment of PAR and processed PAR.The results also revealed that the standardization of processing technology is of great significance to the fluctuations in quality before and after the processing of traditional Chinese medicine.

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A strategy for the discovery and validation of toxicity quality marker of Chinese medicine based on network toxicology

Cited by 27 publications

References 26 publications

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Probing the Mechanism of Hepatotoxicity of Hexabromocyclododecanes through Toxicological Network Analysis

Quantitative analysis of different batches of raw, wine‐processed, and vinegar‐processed Paeoniae Alba Radix using ultra‐performance convergence chromatography coupled with photo diode array detection

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