A Stretchable and Transparent Electrode Based on PEGylated Silk Fibroin for In Vivo Dual‐Modal Neural‐Vascular Activity Probing

Cui, Yajing; Zhang, Fan; Chen, Geng; Yao, Lin; Zhang, Nan; Liu, Zhiyuan; Li, Qingsong; Zhang, Feilong; Cui, Zequn; Zhang, Ke‐Qin; Li, Peng; Cheng, Yuan; Zhang, Shaomin; Chen, Xiao

doi:10.1002/adma.202100221

Cited by 68 publications

(85 citation statements)

References 71 publications

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“…Wearable devices have attracted emerging attention in recent years due to their excellent interactivity with the human body and the ability for long-term monitoring, which are therefore widely applied in the monitoring of small human motions, [1,2] large body movements, [3,4] and biochemical detection. [5,6] As required by the flexibility and sensitivity of wearable devices, soft materials such as elastomers and hydrogels are commonly employed as the skeletons of flexible devices, while carbon nanotubes (CNTs), graphene, conductive polymers, and other structural color-based composite hydrogel was fabricated with the above silica PCs.…”

Section: Introductionmentioning

confidence: 99%

Fast Self‐Assembly of Photonic Crystal Hydrogel for Wearable Strain and Temperature Sensor

et al. 2022

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functional materials are used as additives to endow devices with functional properties. [7,8] Although with great success, readouts of the response behaviors of wearable devices generally require sophisticated instruments, which are usually expensive and inconvenient to be portable. To this end, visual colors, which are directly integrated into wearable devices, offer an emerging strategy to intuitively obtain the responsive signals of wearable devices. [9][10][11] Structure color, different from dye and pigment, is a result of a microscale or nanoscale periodic structural material, which commonly exists in natural structures such as butterfly wings and chameleon skins. [12,13] When these periodic distances are within a few hundreds of nanometers, a modulation of the incident white light occurs, resulting in a strengthening in the light with the specific wavelength determined by Bragg's law. [12] Benefiting from structure colors, numerous visual devices, such as actuators, [14] flexible electronics, [15,16] strain sensors, [17][18][19] and other sensors [20,21] have been developed to monitor human motions, [15,16,22] temperature, [23,24] pH, [24] chemical sensing, [25][26][27] and cell monitoring. [28] At present, structure colors are obtained mainly via two schemes, including top-down fabrications such as direct laser writing, [29] nanoimprinting, [30] solvent release, [31] and bottom-up methods such as the self-assembly of nanoparticles (NPs), [32][33][34][35] cellulose nanocrystals, [36][37][38] block copolymers, [24,39] under capillary force [40,41] or external forces. [42,43] However, the former methods generally require the assistance of sophisticated and expensive equipment, whereas the latter methods generally take a long period from days [14,44] to weeks [24,45,46] with precise environmental control. Therefore, the development of a fast, robust, and convenient fabrication method for photonic crystals (PCs) is highly desired in the field of wearable sensors.Herein, we introduce a fast self-assembly method for PCs based on horizontal precipitation of silica NPs. With a hydrophilic polydimethylsiloxane (PDMS) fence on the glass substrate, a meniscus liquid surface between the adjacent NPs was obtained horizontally, which was beneficial to achieve improved and high-quality periodic silica PC (Figure 1a,b). Moreover, this self-assembly process could be completed within 1-4 h due to the less silica dispersion to evaporate, which was much faster than conventional vertical deposition methods and had better quality than horizontal deposition. [47,48] Furthermore, a Structural colors from photonic crystals (PCs) have attracted emerging attention in the research area of wearable sensors. Conventional self-assembly of PC takes days to weeks. Here, a fast self-assembly method of PC with horizontal precipitation of silica nanoparticles (NPs) in a polydimethylsiloxane fence, which can be completed within 1-4 h depending on the fence parameters, is introduced. The resultant PC exhibits tunable structural colors in the e...

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Section: Introductionmentioning

confidence: 99%

Fast Self‐Assembly of Photonic Crystal Hydrogel for Wearable Strain and Temperature Sensor

et al. 2022

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“…In addition, a stretchable silk hydrogel electrode based on PEGylated SF and PEDOT:PSS has also been reported by Cui et al. [ 165 ]. It demonstrated that the PEGylated silk protein with poly(ethylene glycol) diglycidyl ether (PEGDE) had significantly improved the Young's modulus and stretchability of the hydrogel compared to traditional silk hydrogel, and hence realized a stretchable, nontransient, and relative stable conformal electronic for neural activity characterization [ 165 ].…”

Section: Advanced Biomedical Applications Of Rsf Materialsmentioning

confidence: 77%

Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

Yao

Zou

Fan

et al. 2022

Materials Today Bio

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“…During this period, a small amount of solution was dropped on the activated silicon wafer every 12 h and left to stand overnight in a dry and clean area. After the water was fully evaporated and dried, the silicon wafer containing the sample was pasted on the electron microscope sample stage with a conductive adhesive, and gold was sprayed with a spray current of 30 mA in a vacuum state for 2 min [ 41 ]. The microscopic morphology of the sample surface was observed under a scanning electron microscope (Nova NanoSEM 450, Hillsboro, OR, USA) with a shooting voltage of 15 kV.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Natural Silk Fibroin Hydrogel for Protein Drug Delivery

et al. 2022

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In recent years, hydrogels have been widely used as drug carriers, especially in the area of protein delivery. The natural silk fibroin produced from cocoons of the Bombyx mori silkworm possesses excellent biocompatibility, significant bioactivity, and biodegradability. Therefore, silk fibroin-based hydrogels are arousing widespread interest in biomedical research. In this study, a process for extracting natural silk fibroin from raw silk textile yarns was established, and three aqueous solutions of silk fibroin with different molecular weight distributions were successfully prepared by controlling the degumming time. Silk fibroin was dispersed in the aqueous solution as “spherical” aggregate particles, and the smaller particles continuously accumulated into large particles. Finally, a silk fibroin hydrogel network was formed. A rheological analysis showed that as the concentration of the silk fibroin hydrogel increased its storage modulus increased significantly. The degradation behavior of silk fibroin hydrogel in different media verified its excellent stability, and the prepared silk fibroin hydrogel had good biocompatibility and an excellent drug-loading capacity. After the protein model drug BSA was loaded, the cumulative drug release within 12 h reached 80%. We hope that these investigations will promote the potential utilities of silk fibroin hydrogels in clinical medicine.

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A Stretchable and Transparent Electrode Based on PEGylated Silk Fibroin for In Vivo Dual‐Modal Neural‐Vascular Activity Probing

Cited by 68 publications

References 71 publications

Fast Self‐Assembly of Photonic Crystal Hydrogel for Wearable Strain and Temperature Sensor

Fast Self‐Assembly of Photonic Crystal Hydrogel for Wearable Strain and Temperature Sensor

Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

Preparation and Characterization of Natural Silk Fibroin Hydrogel for Protein Drug Delivery

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