A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

Abstract

Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically flexible, stretchable, and can conformally adhere to the skin wound throughout the entire healing process. Real-time metabolic and inflammatory monitoring in a series of preclinical in vivo experiments showed high accuracy and electrochemical stability of the wearable patch for multiplexed spatial and temporal wound biomarker analysis. The combination therapy enabled substantially accelerated cutaneous chronic wound healing in a rodent model.

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

“…Different 3D configurations have been developed to induce unique structural functionalities, thereby adding more dimensions to the design of flexible electronics. Such structural revolutions have transformed the roles of electronic devices from solely electrical to mechanoelectrical, ,, optoelectrical, , magnetoelectrical, thermoelectrical, , chemoelectrical, ,,, bioelectrical, ,,− and physically intelligent. ,,, …”

A Computationally Assisted Approach for Designing Wearable Biosensors toward Non‐Invasive Personalized Molecular Analysis

“…Wearable sensors have great potential to revolutionize the field of personalized medicine as they can continuously and non‐invasively monitor an individual's physiological and health status. [ 1–9 ] While commercially available wearable health monitors mainly track physical vital signs, wearable sweat biosensors could offer rich health information at molecular levels. [ 10–23 ] Continuous analysis of sweat biomarkers including amino acids, vitamins, metabolites, drugs, hormones, and proteins could have a profound impact in remote monitoring and management of a variety of health conditions such as stress, gout, metabolic disorders, cardiovascular diseases, and cancers.…”

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

“…Moreover, the limited and fragmented nature of the information provided during hospital visits can restrict the amount of information that the doctor can obtain, potentially affecting the accuracy of various diagnoses. As a result, there is a strong demand for wearable medical devices that are customized to the individual, convenient, and capable of obtaining real-time information related to the health of the human body. − …”