A Strong Integrated Strength and Toughness Artificial Nacre Based on Dopamine Cross-Linked Graphene Oxide

Cui, Wei; Li, Mingzhu; Liu, Jiyang; Wang, Ben; Zhang, Chuck; Jiang, Lei; Cheng, Qunfeng

doi:10.1021/nn503755c

Cited by 364 publications

(331 citation statements)

References 37 publications

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“…Recent studies reported that the dopamine could self‐polymerize to form surface‐adherent polydopamine (PDA) films onto a wide range of materials either organic or inorganic by a spontaneous oxidation reaction in an alkaline solution (pH = 8.5) 18, 19, 20, 21. It was widely used as material surface modification since the PDA shells are stable enough to reach the target cells after intravenous injection 22, 23.…”

Section: Introductionmentioning

confidence: 99%

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

et al. 2018

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Carrier‐free nanoparticles with high drug loading have attracted increasing attention; however, in situ on‐demand drug release remains a challenge. Here, a novel near‐infrared (NIR) laser‐induced blasting carrier‐free nanodrug delivery system is designed and fabricated by coating doxorubicin (DOX) nanoparticles (DNPs) with a polydopamine film (PDA) that would prolong the blood circulation time of DNPs and avoid the preleakage of the DOX during blood circulation. Meanwhile, the NH4HCO3 is introduced to trigger in situ “bomb‐like” release of DOX for the production of carbon dioxide (CO2) and ammonia (NH3) gases driven by NIR irradiated photothermal effect of PDA. Both in vitro and in vivo studies demonstrate that the carrier‐free nanovectors with high drug loading efficiency (85.8%) prolong tumor accumulation, enhance chemotherapy, achieve the synergistic treatment of chemotherapy and photothermal treatment, and do not induce any foreign‐body reaction over a three‐week implantation. Hence, the delicate design opens a self‐assembly path to develop PDA‐based NIR‐responsive multifunctional carrier‐free nanoparticles for tumor therapy.

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Section: Introductionmentioning

confidence: 99%

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

et al. 2018

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“…This unique existence of multiple interface interactions and building blocks in natural materials inspires constructing different synergistic effects in bioinspired nanocomposites. For example, Cui et al [86] demonstrated synergistic interface interactions of hydrogen and covalent bonding in GO-based nanocomposites. The dopamines could not only be grafted to GO nanosheets, but also self-polymerized into polydopamine (PDA).…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

High‐Performance Nanocomposites Inspired by Nature

2017

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Over the eons of evolutionary time, natural materials, including nacre, bone, lobster cuticle, and many others, developed delicate multiscale structures demonstrating outstanding properties. These natural materials provide endless inspiration for the fabrication of novel bioinspired structural materials. Extensive research has revealed the mechanism responsible for natural materials' properties and shows that high-performance structural materials could be fabricated via bioinspired strategies. [1][2][3][4][5][6][7][8][9][10] With the quest to develop novel bioinspired materials, it is essential to refine some basic scientific principles that can guide bioinspired fabrication.Recent research has indicated that the amplification of natural materials' mechanical properties far beyond those of the components that comprise them originates mainly from: i) a hierarchical micro-/nanoscale architecture and ii) abundant effective interface interactions. Here, we follow the roadmap of "discovery, invention, and creation," as shown in Figure 1, to give insight into the development of bioinspired structural materials. In the "discovery" section, natural materials are described as a source of inspiration. Bioinspired nanocomposites can be invented to mimic or even to surpass natural materials' attributes, as described in the "invention" section. We illustrate how the basic principles could work for bioinspired nanocomposites with different building blocks and fabrication approaches. Finally, in the "creation" section, we review novel multifunctional nanocomposites with properties that natural materials rarely possess. To provide a vision and inspiration for future research, we conclude with our perspectives on new and promising directions in the field, along with problems remaining to be solved. Discovery: Natural Materials Orderly Hierarchical ArchitecturesNatural materials are made at ambient temperatures from a relatively small number of ingredients that exhibit rather meager properties. Almost all of them are composites with orderly hierarchical architectures that arrest crack propagation, thus preventing catastrophic failure. Insight into the architecture of a typical natural material is the key to understanding the superiority of the biomimetic strategy for making novel synthetic materials.Natural materials, including nacre, bone, and the lobster cuticle, exhibit excellent mechanical properties, combining high strength and toughness. Such materials have the added benefit of being light in weight. These advantageous features are due to such natural materials' orderly hierarchical architectures and abundant interface interactions. How to utilize these design principles created by nature to fabricate high-performance bioinspired nanocomposites remains a great research challenge. A logical roadmap for developing these nanocomposites can be described as "discovery, invention, and creation." Here, the discovery of the relationship between natural materials' design principles and such materials' extraordinary mechanical proper...

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“…[87][88][89][90][91][92][93][94][95][96] Vacuum filtration was used to rapidly self-assemble GO/gellan gum into aligned nacre-like films. The produced films were strong and flexible.…”

Section: Gellan Gum Filmsmentioning

confidence: 99%

Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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A Strong Integrated Strength and Toughness Artificial Nacre Based on Dopamine Cross-Linked Graphene Oxide

Cited by 364 publications

References 37 publications

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

High‐Performance Nanocomposites Inspired by Nature

Graphene Oxide/Polymer‐Based Biomaterials

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