A Study of Capillary Permeability in Experimental Burns and Burn Shock Using Radioactive Dyes in Blood and Lymph 1

Exchange of iron and transferrin across endothelial surfaces in the rat and rabbit

“…Maximum lymph 59Fe concentrations were found 50-75 min after injection, and plasma and lymph specific activities did not become equal until after longer times varying up to 12-24 hr. After intravenous injection of a radioactive inorganic ion, equilibrium between plasma and lymph, with equal concentrations and specific activities, is reached within 20 min (Cope & Moore, 1944). However, with labelled protein the rate of transfer from plasma to lymph is similar to that found for 59Fe in the present work (Cope & Moore, 1944;Wasserman & Mayerson, 1951;Abdou, Reinhardt & Tarver, 1952;Morris, 1956).…”

“…After intravenous injection of a radioactive inorganic ion, equilibrium between plasma and lymph, with equal concentrations and specific activities, is reached within 20 min (Cope & Moore, 1944). However, with labelled protein the rate of transfer from plasma to lymph is similar to that found for 59Fe in the present work (Cope & Moore, 1944;Wasserman & Mayerson, 1951;Abdou, Reinhardt & Tarver, 1952;Morris, 1956). Furthermore the iron, total protein or ,8-globulin found in the first 24 hr lymph all were similar proportions of the amount present in the plasma (mean values 85, 78 and 93 % respectively).…”

Kinin‐forming activity and histamine in lymph after tissue injury

“…As there is a passage of plasma proteins from the blood vessels into the lymph after severe injury (Glenn, Petersen & Drinker, 1942;Glenn, Muus & Drinker, 1943;Cope & Moore, 1944), the possibility must be considered that the increased kinin-forming activity is an incidental change resulting from this non-specific effect. Against this view is the finding that an increase in lymph protein as well as in lymph flow can be obtained without a concomitant increase in kinin-forming activity.…”

Blood Volume Alterations in Congestive Heart Failure

“…Schultz, Hammarsten, Heller, and Ebert (33) demonstrated that the amount of Il3l-labeled albumin appearing in thoracic duct lymph during the period of plasma volume determination does not significantly influence the measurement of plasma volume. In the dog, at least, intravenously administered tagged serum proteins equilibrate more rapidly with thoracic duct lymph than the lymph from the neck or limbs (34).…”