A Study of Sublingual Absorption I. Several Factors Influencing the Rate of Absorption*

“…The sublingual artery stems from the lingual arterythe body's main blood supply to the tongue and the floor of the mouthwhich arises from the external carotid artery. The proximity with the internal carotid artery allows fast access to its route supplying the greater part of the cerebral hemisphere [8,9] Factors affecting the sublingual absorption [10]  Lipophilicity of drug: For a drug to be absorbed completely through sublingual route, the drug must have slightly higher lipid solubility than that required for GI absorption is necessary for passive permeation.  Solubility in salivary secretion: In addition to high lipid solubility, the drug should be soluble in aqueous buccal fluids i.e.…”

Section: Review Articlementioning

confidence: 99%

Sublingual tablets: an overview

Sah¹,

Badola²,

Kothiyal³

2016

IJPBR

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Oral administration is one of the most convenient forms for the intake of drug due to ease of administration, painless, versatility, and paramount patient compliance. The demand of fast disintegrating tablets has been growing, during the last decades especially for geriatric and pediatric patients due to dysphasia. So the new drug delivery known as orally disintegrating tablets came to existence. As nowadays most of the people need effective relief within a short period of time so sublingual is the most suitable form of administration. These tablets disintegrate and dissolve rapidly in saliva due to interaction with our salivary enzymes.

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“…[1] Mechanism of sublingual administration [2] The absorption potential of the buccal mucosa is influenced by the lipid solubility and therefore the permeability of the solution (osmosis); the ionisation (pH); and the molecular weight of the substances. For example, absorption of some drugs via the buccal mucosa is shown to increase when carrier pH is lower (more acidic) and decrease with a lowering of pH (more alkaline).…”

Section: Introductionmentioning

confidence: 99%

“…For example, absorption of some drugs via the buccal mucosa is shown to increase when carrier pH is lower (more acidic) and decrease with a lowering of pH (more alkaline). [2] The absorption potential of the buccal mucosa is influenced by the lipid solubility and therefore the permeability of the solution (osmosis); the ionisation (pH); and the molecular shown to increase when carrier pH is lower (more acidic) and decrease with a lowering of pH (more alkaline). The mouth is lined with a mucous membrane which is covered with squamous epithelium and contains mucous glands.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Sublingual Tablets of Gabapentin

Ahmed¹

2017

WJPPS

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Oral administration is one of the most convenient forms for the intake of drug due to ease of administration, painless , versality and paramount patient compliance. The demand of fast disintegrating tablets has been growing, during the last decades especially for geriatric and pediatric patients due to dysphasia. So the new drug delivery known as orally disintegrating tablets came to existence. An attempt has been made to prepare fast dissolving tablets of Gabapentin using super disintegrants like cros carmellose sodium, crospovidone, PVP K-30. All the formulations were evaluated for post-compression parameters like hardness, friability, dug content uniformity, dissolution test and disintegration test. The  max of gabapentin was scanned for 0.1N HCL buffer. The maximum absorbance 221 nm was done. Finally F3 formulation is best formulation based on drug release characteristics

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A Study of Sublingual Absorption I. Several Factors Influencing the Rate of Absorption*

Cited by 13 publications

References 68 publications

Absorption of Implanted Solid Drug

Absorption of Implanted Solid Drug

Sublingual tablets: an overview

Formulation and Evaluation of Sublingual Tablets of Gabapentin

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