A study of the diagnostic value of Inhibin A Tests for occurrence of preeclampsia in pregnant women

Broumand, Farzaneh; Lak, Shaker Salari; Nemati, Farhad; Mazidi, Atefeh

doi:10.19082/6186

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…PE is responsible for the deaths of more than 500, 000 neonates, fetuses, and 70, 000 maternal deaths worldwide, with a global incidence rate of 2%∼8% [ 1 ]. Severe pre-eclampsia can be followed by placental abruption, eclampsia, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count syndrome), and even multiple systemic organ damage [ 2 ]. At present, the pathogenesis of PE is thought to be related to abnormal placental formation.…”

Section: What Is Known and Objectivementioning

confidence: 99%

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of “Chuanxiong Rhizoma: Radix Salviae miltiorrhizae” Herb Couples in the Treatment of Preeclampsia

Wei

Xiong

Zhu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of the study is to explore the molecular mechanism of activating blood circulation and dispersing stasis herbs in the treatment of pre-eclampsia with Chuanxiong Rhizoma-Radix Salvia miltiorrhiza. Methods. The chemical composition and targets of Chuanxiong Rhizoma-Radix Salvia miltiorrhiza were retrieved from the TCMSP database, and a PPI network was constructed for common genes. Subsequently, a graph of the “active component-target-action pathway” was plotted by Cytoscape 3.7.2 and a KEGG pathway enrichment was performed using the R language cluster profiler package. Molecular docking was conducted between the top five PPI targets of Chuanxiong Rhizoma-Radix Salvia miltiorrhiza. Results. According to network pharmacology, there were 32 target genes, 60 active components, and 59 pathways in Chuanxiong Rhizoma-Radix Salvia miltiorrhiza, and its most evident effects were exerted on G-protein-coupled amine receptors and the neuroactive ligand-receptor interaction signaling pathway. Molecular docking indicated that the target protein had a good binding ability with the drugs. Conclusion. Chuanxiong Rhizoma-Radix Salvia miltiorrhiza have therapeutic effects in pre-eclampsia, as confirmed by the results of molecular biology analysis. Thus, the Chuanxiong Rhizoma-Radix Salvia miltiorrhiza regimen provides a basis for the treatment of pre-eclampsia using traditional Chinese medicine.

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Section: What Is Known and Objectivementioning

confidence: 99%

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of “Chuanxiong Rhizoma: Radix Salviae miltiorrhizae” Herb Couples in the Treatment of Preeclampsia

Wei

Xiong

Zhu

2022

Evidence-Based Complementary and Alternative Medicine

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“…Refer to Table 3 for specific markers used in each case group b Second Trimester (T2) Biochemical Markers: AFP, uE3, hCG, PAPP-A, PlGF. Refer to Table 3 by others [18]. We suspect this is due to the small number of early PE pregnancies involved in our study.…”

Section: Discussionmentioning

confidence: 89%

Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia

Huang

Bedford

Rashid

et al. 2022

BMC Pregnancy Childbirth

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Background Abnormal levels of maternal biochemical markers used in multiple marker aneuploidy screening have been associated with adverse pregnancy outcomes. This study aims to assess if a combination of maternal characteristics and biochemical markers in the first and second trimesters can be used to screen for preeclampsia (PE). The secondary aim was to assess this combination in identifying pregnancies at risk for gestational hypertension and preterm birth. Methods This case-control study used information on maternal characteristics and residual blood samples from pregnant women who have undergone multiple marker aneuploidy screening. The median multiple of the median (MoM) of first and second trimester biochemical markers in cases (women with PE, gestational hypertension and preterm birth) and controls were compared. Biochemical markers included pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF), human chorionic gonadotropin (hCG), alpha feto-protein (AFP), unconjugated estriol (uE3) and Inhibin A. Logistic regression analysis was used to estimate screening performance using different marker combinations. Screening performance was defined as detection rate (DR) and false positive rate (FPR). Preterm and early-onset preeclampsia PE were defined as women with PE who delivered at < 37 and < 34 weeks of gestation, respectively. Results There were 147 pregnancies with PE (81 term, 49 preterm and 17 early-onset), 295 with gestational hypertension, and 166 preterm birth. Compared to controls, PE cases had significantly lower median MoM of PAPP-A (0.77 vs 1.10, p < 0.0001), PlGF (0.76 vs 1.01, p < 0.0001) and free-β hCG (0.81 vs. 0.98, p < 0.001) in the first trimester along with PAPP-A (0.82 vs 0.99, p < 0.01) and PlGF (0.75 vs 1.02, p < 0.0001) in the second trimester. The lowest first trimester PAPP-A, PlGF and free β-hCG were seen in those with preterm and early-onset PE. At a 20% FPR, 67% of preterm and 76% of early-onset PE cases can be predicted using a combination of maternal characteristics with PAPP-A and PlGF in the first trimester. The corresponding DR was 58% for gestational hypertension and 36% for preterm birth cases. Conclusions Maternal characteristics with first trimester PAPP-A and PlGF measured for aneuploidy screening provided reasonable accuracy in identifying women at risk of developing early onset PE, allowing triage of high-risk women for further investigation and risk-reducing therapy. This combination was less accurate in predicting women who have gestational hypertension or preterm birth.

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“…A study from Iran in 2018 by the Broumand et al . [ 23 , 24 ] group established Inhibin A MoM = 1.25 in the second trimester had significantly associated with PE (sensitivity = 83.83%) in 300 pregnant women. However, they have considered only inhibin as one biomarker and PE in one adverse outcome in account for association establishment in limit.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Low Birth Weight by Quadruple Parameters in High-Risk Pregnancies

Gupta

Pradhan

Mishra

et al. 2022

International Journal of Applied &Amp; Basic Medical Research

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Context: Aneuploidy screening is done in the early second trimester of pregnancy among all pregnant women as compulsory, with a special focus on those who had abnormal ultrasound parameters, higher dual marker risk, or other comorbidities. Recently, all individual quad markers of conventional trisomy screening have been suggested as useful in predicting adverse pregnancy outcomes (APO) such as preeclampsia, preterm labor, small for gestational age, and placental abruptions. However, similar studies on Indian pregnant women are limited. Hence, this study was intended to find the relation of quadruple markers with any other APO than aneuploidy. Materials and Methods: A retrospective study was conducted in a Tertiary Care multi-specialty hospital in North India. Data from 252 pregnant women’s quadruple test was analyzed. The association of abnormal value of quadruple markers (human chorionic gonadotropin [HCG]/alpha-fetoprotein/uE3/Inhibin A) with adverse outcomes was evaluated. Multiple logistic regression analysis and classification and regression tree were used to predict the significant risk factor in high-risk pregnancies. Results: In the study, a total ( n = 252) of pregnant women, 190 were screened as high-risk pregnancies, whereas the remaining 62 were reported as low-risk using trisomy screening in the quadruple test. Baby birth weight was observed to be significantly associated with Inhibin-A, and HCG ( P < 0.001), whereas Corrected (Corr)-multiple of median (MoM)-HCG (>1.415) and Inhibin-A Corr-MoM (>364.175) were the suitable predictor for the LBW. Both parameters were significantly higher in the high-risk group as compared to the low-risk group (each P < 0.05). Conclusion: Abnormal deviation of biochemical markers from aneuploidy screening assessment could help predict other perinatal adverse outcomes such as low birth weight babies.

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A study of the diagnostic value of Inhibin A Tests for occurrence of preeclampsia in pregnant women

Cited by 12 publications

References 20 publications

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of “Chuanxiong Rhizoma: Radix Salviae miltiorrhizae” Herb Couples in the Treatment of Preeclampsia

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of “Chuanxiong Rhizoma: Radix Salviae miltiorrhizae” Herb Couples in the Treatment of Preeclampsia

Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia

Prediction of Low Birth Weight by Quadruple Parameters in High-Risk Pregnancies

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