A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers

Abstract

In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa.

Epidemiology, Pathogenesis, and Treatment of the Common Cold

“…56 The role of kinins in the pathogenesis of common cold symptoms is less clear, however, in light of the failure of a bradykinin antagonist to alleviate common cold symptoms. 57 Similarly, in a more recent study, steroid therapy significantly reduced the concentration of kinins in nasal washes but had no effect on symptoms. 58 The interleukins IL-1␤, IL-6, and IL-8 have also recently been reported in the nasal secretions of symptomatic subjects with experimental rhinovirus colds.…”

Viruses as precipitants of asthma symptoms III. Rhinoviruses: molecular biology and prospects for future intervention

“…Thus there is now some evi- Interferons alpha4-beta [50][51][52][53] Several 'old' drugs [49] New drugs, e.g. R 61837, R 77975 [60] Monoclonal antibody against receptor [48] Soluble receptor [62] Peptide(s) [64] NPC 567 (bradykinin antagonist) [66] Nedocromil sodium [67] Corticosteroids [70][71][72][73][74] Prevents, but side-effects long term Generally inactive by oral or intranasal roule, many active in tissue culture Effective in treatment of colds in preliminary studies Modifies course of eold, effective in tissue culture Effective in tissue culture Serotype cross-reactive peptides not yet developed No effect, others being developed Limited effect Limited effect in colds, significant benefit in exacerbations of asthma dence for mechanisms whereby atopic or asthmatic subjects may be more suseeptible to rhinovirus infections, though further studies are needed in normal and asthmatic subjects before any firm conclusions may be drawn.…”

Viral rhinitis

“…The concentration and time course of the production of kinins are correlated with symptom severity. However, steroid therapy significantly reduced kinins in nasal lavage fluids but had no effect on symptoms, and bradykinin antagonists did not affect signs and symptoms in a number of experimental RV studies [19].…”