A Study of the Mechanism of Nucleinate-Induced Leucopenic and Leucocytic States, With Special Reference to the Relative Rôles of Liver, Spleen, and Bone Marrow

Abstract

The newer concept that there is normally a wide range of fluctuation in the total number of circulating red and white ceils (1-5), reopens the whole question of the meaning of variations in blood counts. To many conditions, such as digestion and exercise, and to many chemical substances have been attributed specific changes in the blood count, which now are known to fall within the more recently established limits of the normal. Hence, in distinguishing between the delivery of new cells from marrow or lymph glands, and changes in distribution of cells already within the circulation, it becomes necessary to study all the factors that might be involved. Each particular stimulus under consideration must be known with reference to its particular point and mode of activity. As will be demonstrated in this paper the subject can only be analyzed in the living animal, for the position of cells in the blood vessels after death is no indication of their distribution during life. In the problem it is essential to study the influence of vasomotor reactions on the distribution of blood cells, to consider possible changes in blood volume, and especially to analyze the r61e of various organs on the peripheral concentration of the cells.The observation by Sabin (6), in a survey of normal living blood cells, of certain "non-motile" polymorphonuclear neutrophils, and the 403 on

Nucleotide Therapy in Agranulocytosis

“…Since in this condition the other blood elements are usually not affected (22), this disease should lend itself to treatment by the stimulation of the polymorphonuclear elements by nucleotides such as adenine sulfate and guanine hydrochloride. Doan, Zerfas, Warren and Ames (23) and Reznikoff (24) have shown that the nucleotides, when given intravenously, cause a marked increase in the polymorphonuclear cells in rabbits without any effect on the temperature or on blood cells other than the granulocytes. In the patients to be described 0.5 gram of the nucleotide was given intravenously in about 20 cc.…”