A Study of the Peristaltic Conduction Mechanism in the Canine Ureter

Butcher, H. R.; Sleator, W. W.; Schmandt, W

doi:10.1016/s0022-5347(17)66427-9

Cited by 24 publications

(8 citation statements)

References 7 publications

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“…Vary ing the ureter temperature over this range causes a change in propagation velocity of the order of 5 mm/s. This value is in good agreement with values found for the tem perature dependence of the action potential conduction velocity of the canine ureter in situ [Butcher et al, 1957]: 7.5%/°C. The dependence on the interstimulus interval is nonlinear, and reducing the rest interval between stim ulations to 10 s reduces the propagation velocity by only about 10%.…”

Section: Discussionsupporting

confidence: 90%

“…Since in vivo the natural period be tween contractions is often of the order of 10 s, we must ascribe this to the condition of the tissue in vitro. Inter stimulus intervals as long as 10 s were reported to signif icantly affect ureteral conduction in guinea pig ureter in vitro also [Vereecken, 1973], in contrast to the canine ureter in situ which shows no reduction in conduction velocities at interstimulus intervals as short as 3 s [Butcher et al, 1957], The observed dependence of propagation velocity on stimulus interval can be understood from a model de scribing the ureter as a linear series of excitable units with a relative refractoriness [van Duyl, 1984[van Duyl, , 1985, In this model, excitation of a contractile unit takes place when the rising ramp of an action potential intersects the strength-duration curve of the tissue. A decrease of the interstimulus interval causes a shift along this curve which results in a prolonged rise time of the action poten tial before the curve is intersected.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Temperature and Stimulus Interval Variations on the Propagation of Contractions in the Pig Ureter

Mastrigt¹,

Wetering²,

Glerum³

1986

Urol Int

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The influences of ureter temperature and time interval between stimulations on the velocity of propagation of contractions in the pig ureter were studied in vitro. The propagation velocity was calculated from electromyogram signals measured at regular distances along the ureter. It was found that a temperature decrease of 3°C causes a velocity decrease of nearly 5 mm/s. The influence of the interstimulus interval is much smaller: a reduction from 300 to 10 s causes a 10% drop in propagation velocity. Both phenomena can be understood from changes in the strength-duration curve describing the excitability of the tissue and clarify the discrepancies between propagation velocity measurements in vitro and in vivo.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Influence of Temperature and Stimulus Interval Variations on the Propagation of Contractions in the Pig Ureter

Mastrigt¹,

Wetering²,

Glerum³

1986

Urol Int

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“…Furthermore, research concerning the influence of drugs on ureteral smooth muscle activity has produced conflicting results (Lapides, 1948;Butcher, Sleator & Schmandt, 1957;Kiil, 1957;Boatman, Lewin, Culp & Flocks, 1%7;Ulmsten, 1974). Some authors concluded that the ureter was inert to cholinergic drugs (Agar, 1948;Butcher et al, 1957;Weinberg & Maletta, 1961;Ross, Edmond & Grif-Present address: Dept.…”

mentioning

confidence: 99%

“…Some authors concluded that the ureter was inert to cholinergic drugs (Agar, 1948;Butcher et al, 1957;Weinberg & Maletta, 1961;Ross, Edmond & Grif-Present address: Dept. of Pharmacology, Leo Research, Fack, S-25100 Helsingborg, Sweden.…”

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confidence: 99%

The Effects of Some Anticholinergic Compounds on the Rabbit Ureter

Sjögren

Ulmsten

1977

Scandinavian Journal of Urology and Nephrology

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Atropine, emeprone, and PR 197--a new anticholinergic compound--were examined for their possible effects on the rabbit ureter in situ. Ureteral pressure, recorded at two levels simultaneously, and intravesical pressure were studied. The effects of the substances were recorded in both normal (unobstructed) and obstructed ureters. It was found that all the substances, but especially PR 197, produced a fall in the basic intra-ureteral pressure, which was most pronounced in animals with obstructed ureters. PR 197 also temporarily abolished the ureteral peristalsis, while atropine and emeprone did not have this effect.

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“…Butcher (14) stated that only histamine and antihistamine drugs effect change in action potential shape or conduction velocity, so the mechanism of conduction might be the release some histamine like substance by a contracting cell which stimulates contraction of neighbouring cells.…”

Section: Effects Of Drugsmentioning

confidence: 99%

Recovery Curve and Conduction of Action Potentials in the Ureter of the Guinea-Pig

Ichikawa

Ikeda

1960

Jpn.J.Physiol

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As is well known, immediately after stimulation, excitable tissue possesses a stage of complete inexcitability, which is followed by a period of reduced excitability and then, sometimes, by a stage of hyper-excitability.The change of conduction velocity of excitation and the change of responsiveness also occur.Many works have been done on these problems using skeletal muscle and nerve. As smooth muscles have rather unstable excitability, quantitative research is difficult to do.The muscle of ureter is visceral smooth muscle, but it is somewhat different from stomach and uterine muscles and the like. Its refractory phase is long as heart muscle and the musculature of ureter lacks of any summation of the mechanical responses (1,2).And the ureter seems to be an excitable unit as a whole. It also has a pace-maker near kidney, so without this portion it is difficult to cause a spontaneous contraction. Because of these characteristics ureter has, the ureter of guinea-pig is used to obtain the recovery curve of its responsiveness.At the same time, some discussions are given here about the action potentials and the conduction of excitation in smooth muscle of the ureter. METHODUreters were removed from guinea-pigs anesthetized by sodium pentobarbital or ether and were kept in oxygenated Ringer-Krebs solution modified by Biilbring (3). The solution was of the following composition: NaCl 0.78 g.; KCl 0.035 g.; CaCl2 0.028 g.; NaHCO3 0.137 g.; NaH2PO4 0.0165 g.; MgCl2 0.029 g. and dextrose 0.14 g. in 100 ml distilled water. The contraction of ureter muscle was recorded with an ink-writing oscillograph after the mechanoelectro transduce by a photo-electric tube.The ureter was mounted in a chamber and partly immersed in Ringer-Krebs solution. The ureter was fixed by a V shaped slit at one end, the other end was tied with a silk thread and this thread was connected to a flag which controlled the light value to the photo-electric tube.Capillary calomel electrodes of about 2mm. diameter were arranged for recording the action potentials. To prevent the moving of

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A Study of the Peristaltic Conduction Mechanism in the Canine Ureter

Cited by 24 publications

References 7 publications

Influence of Temperature and Stimulus Interval Variations on the Propagation of Contractions in the Pig Ureter

Influence of Temperature and Stimulus Interval Variations on the Propagation of Contractions in the Pig Ureter

The Effects of Some Anticholinergic Compounds on the Rabbit Ureter

Recovery Curve and Conduction of Action Potentials in the Ureter of the Guinea-Pig

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