This study was undertaken to explore the effects of instructions regarding how to respond (facilitatory and inhibitory) on the conditioning of the galvanic skin response, and to examine, through the use of a relevant personality measure, individual differences in compliance to those instructions. The data revealed differential responding in accord with the instructional set and, although differential compliance was not demonstrated, behavioral differences were observed with respect to the personality extremes employed. On the assumption that the CS-UCS interval might have to be extended for instructional and personality variables to operate, 2 different interstitnulus intervals were employed. The results suggested that instructions might have an effect upon the classical interstimulus interval function.