A Study on Preparation and Use of Nano Poly Pyrrole and Nano Poly (3,4-Ethylenedioxythiophene) Coated Glassy Carbon Electrode For The Determination of Antihistamine in Pharmaceutical and Urine Sample

Abstract

Pheniramine maleate (PA), an antihistamine, was determined by Differential Pulse Stripping voltammetry using nano polypyrrole (Ppy) and nano poly(3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrodes. The cyclic voltammetric behavior of pheniramine was studied in aqueous acidic, neutral and alkaline conditions. One well-defined oxidation peak was observed in the cyclic voltammograms at all pHs. The influence of pH, scan rate and concentration revealed irreversible electron transfer and the oxidation was diffusion controlled adsorption. The SEM analysis confirmed good accumulation of PA on the electrode surface. A systematic study of influence of various experimental parameters that affect the stripping voltammetric response was carried out and the maximum peak current conditions were arrived at. Calibration was made under maximum peak current conditions. The range of study was 0.05 to 0.4 μg/mL on Ppy/GCE and 0.025 to 0.4μg/mL on PEDOT/GCE and the lower limit of determination were 0.035μg/mL on Ppy/GCE and 0.016μg/mL on PEDOT/GCE. The suitability of the method for the determination of PA in pharmaceutical preparations and urine samples was also ascertained

Electrochemical detection of chlorpheniramine maleate in the presence of an anionic surfactant and its analytical applications

“…The detection limits reported at different electrochemical methods for CPM is tabulated in the Table 1. This method was better as compared to other reported similar methods [17][18][19][20][21][22][23].…”

“…As these methods are rather sophisticated, expensive, time consuming methods. Few attempts have also been made to use electroanalytical technique for the determination of CPM using carbon paste electrodes [17][18][19], modified glassy carbon electrode [20][21][22] and hanging mercury drop electrode [23]. However these methods have attracted much attention of researchers towards to their sensitivity for the determination of organic molecules, rapidity of analysis, inexpensive instrumentation and no complex sample pretreatment are also considered as eco-friendly [24,25].…”

UV-Spectral Studies On Chlorpheniramine Maleate In Pure Form And Pharmaceutical Preparations

“…Histamine drug is primarily composed of CPM which is one of the antihistamines that stop the action of histamine, either by blocking histamine receptors or by stopping the manufacture of histamine. Many methods have been reported for the direct determination of CPM in pharmaceutical preparations, including high-performance liquid chromatography procedures coupled with different types of ultraviolet mass spectrometry detectors [2-8] a micellar electrokinetic chromatography method has been used for the simultaneous determination of paracetamol and CPM [9] a direct current polarographic method had been developed for the determination of CPM in pharmaceutical preparations [10].CPM was also determined by differential pulse stripping voltammetry using nano ppy (poly pyrol) and nano PEDOT (poly 3,4-ethylene dioxythiophene) modified glassy carbon electrodes [11]. Simple, rapid, and accurate methods are described for the simultaneous determination of CPM and phenylephrine hydrochloride in two-component mixtures, The first method comprised of measurement of difference absorptivities derivatized, The second method zero-crossing derivative spectrophotometry [12].…”

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

“…In the best of our knowledge, no electrochemical method to determine simultaneously these drugs has been reported. CP has been determined in pharmaceuticals using polarography 14 and by differential pulse voltammetry (DPV) using carbon paste electrodes [15][16] , carbon paste electrodes modified with cobalt nanostructures 17 and modified glassy carbon electrodes 18 . Also, the electrochemical oxidation of CP at polytyramine film doped with ruthenium (II) complex, devoted with kinetic and thermodynamic studies have been described 19 .…”