A study on probable correlation of AST/ALT (De Ritis) ratio with the advancement of underlying severity of alcoholic liver disease in the North East Indian population

Deb, Dr.Niladri; Lahon, D. K.; Sharma, Pradeep

doi:10.21276/apjhs.2016.3.2.2

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“…Anti‐ P. gingivalis IgM and length of drinking had a strong inverse association, suggesting an important role of heavy prolonged drinking in altering Ig immune responses, with longer drinking showing a lower immune response . In the moderate AAH group, the IgM response was strongly correlated with the AST:ALT ratio, suggesting active infection of P. gingivalis was associated with progressive liver damage in these patients (most specifically in male patients) . There was no correlation between the AST:ALT ratio and IgM in severe AAH, indicating that this association is more meaningful in moderate AAH and is lost in the severe form of AAH.…”

Section: Discussionmentioning

confidence: 97%

Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis

et al. 2018

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Bacterial infection is frequently observed in patients with alcoholic liver disease (ALD). We examined a possible role of Porphyromonas gingivalis in the development/progression and severity of disease in patients with acute alcoholic hepatitis (AAH). Plasma specimens from 47 patients with AAH (16 moderate, Model for End‐Stage Liver Disease [MELD] score <20]; 31 severe, MELD score >20) and 22 healthy controls (HCs) were collected. Clinical, drinking history (lifetime drinking history [LTDH]), and demographic data were collected. Antibody tests for immunoglobulin (Ig) G, IgM, and IgA against two P. gingivalis strains were performed. Between‐group comparisons and within‐group association analyses were carried out. Patients with severe AAH showed significantly higher plasma levels of IgG, IgA, and IgM against two P. gingivalis strains (W83 and 33277) compared to HCs. Patients with moderate AAH also had significantly elevated anti‐P. gingivalis IgA concentrations for both strains compared to HCs. Male patients with moderate AAH showed a significant inverse association in LTDH and anti‐P. gingivalis IgM. The aspartate aminotransferase:alanine aminotransferase ratio was positively associated with IgM of both strains in male patients with moderate AAH. Female patients with severe AAH showed a significant association between MELD scores and W83 IgM. Conclusion: Antibody response to P. gingivalis in AAH is elevated. Significantly elevated plasma anti‐P. gingivalis IgG, IgA, and IgM in severe AAH provide preliminary data that P. gingivalis could be a novel risk factor in the development/severity of AAH.

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Section: Discussionmentioning

confidence: 97%