A study to assess the relation between severity of hypothyroidism and Lipid parameters

M, Kavitha M; Chandrashekharayya, SH; Kashinakunti, Sangappa Virupaxappa; Manjula, R; Gurupadappa, K

doi:10.5958/2394-6377.2016.00005.8

Cited by 2 publications

(2 citation statements)

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“…Na+/K+/ATPase activity is higher in euthyroid states. Reduced Na+/K+/ ATPase enzymatic activity and impaired Na+/H+ exchange activity of the proximal tubular borders and other specific segments, as part of a decline in cell metabolism in hypothyroid conditions, can contribute to the diminished proximal tubular capacity for Na reabsorption in hypothyroidism which is in consistent with Ahmed S. Abuzaidet [13] and Kavita MM et al [14] leading to hyponatremia in hypothyroid subjects. Hierholzer Ket al [15] stated that hypernatremia in hypothyroidism is the accumulation of interstitial mucopolysaccharides resulting in mutual solute and fluid retention, diminishing effective tissue perfusion and local lymphatic drainage, particularly in myxedema.…”

Section: Discussionsupporting

confidence: 74%

Assessment of Serum Electrolyte in Hypothyroid Patients Attending Chitwan Medical College

Kafle¹,

Mahato²,

Mandal³

et al. 2022

MedS J. Med. Sci.

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INTRODUCTION: Hypothyroidism is a clinical condition resulting from inadequate synthesis of the thyroid hormones. Thyroid hormone has an influence on renal hemodynamics, glomerular filtration, as well as the renin angiotensin aldosterone system and renal electrolyte handling. The aim of present study was to find out the serum concentration of electrolytes sodium and potassium in hypothyroid patients attending a tertiary care hospital. MATERIALS AND METHODS: A hospital-based descriptive cross-sectional study was conducted from 24th July 2019 to November 30th 2019 at Chitwan Medical College Teaching Hospital. A venous blood sample was collected and T3, T4 and TSH levels were measured by using chemiluminescence technology. Sodium and potassium levels in blood were investigated by ion selective electrode (ISE) method. Data were analyzed using IBM SPSS 21 software. RESULTS: In our study parameters (T3, T4 & TSH and Na+) were significant (P<0.05) in hypothyroidism subjects (group II) as compared to control subjects (group I) except for electrolyte potassium which was non-significant at P<0.05. T3 and T4 were found significantly decreased whereas TSH was found elevated in subjects of hypothyroidism (group II) as compared to controls. The level of potassium was within the normal range but it was found not significant as compared to healthy controls. CONCLUSIONS: The study concluded that there was increase in TSH with decrease in T3 and T4 in hypothyroid subjects but the electrolyte sodium was found to be statistically significant.

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Section: Discussionsupporting

confidence: 74%

Assessment of Serum Electrolyte in Hypothyroid Patients Attending Chitwan Medical College

Kafle¹,

Mahato²,

Mandal³

et al. 2022

MedS J. Med. Sci.

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“…Previous studies also found that there was significant positive correlation between serum TSH values and lipid parameters. 11,12 The present study found that significant positive associations between the lipid ratios (Table 4). It was stated that either the ratio of TC/HDL or LDL/HDL i.e CRI-I & II is the best lipid related predictive risk calculators of future cardiovascular events.…”

Section: Discussionsupporting

confidence: 64%

Castelli risk index-1 and atherogenic coefficient are better predictors of cardiometabolic risk in patients with hypothyroidism

Sasikala¹,

Goswami²

2020

IJCBR

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Hypothyroidism resulting from a deficiency of thyroid hormones may be associated with dyslipidaemia. Since altered lipid profile is quite important in predicting CVD risk, therefore the present study aimed to investigate any possible association between the levels of certain lipid indices with thyroid profile and their diagnostic ability of cardiometabolic syndrome in patients with hypothyroidism. A cohort of 40 female patients diagnosed with hypothyroidism was included as cases and thirty age and gender matched healthy females were recruited as controls. Fasting blood samples were collected for analysis of thyroid hormones, cholesterol, triglycerides and high density lipoprotein cholesterol levels by Chemiluminescence immuno-assay, and enzymatic colorimetric methods respectively. Differences in all between groups were tested using parametric independent sample T test. Pearson’s correlation or Spearman rank correlation analysis was done to study the correlations among the parameters as appropriate. Receiver operative characteristic (ROC) curve analysis was performed to study diagnostic utility of parameters.Lipid indices were found to be significantly increased in patients with hypothyroidism when compared to the controls. Castelli risk index-I (CRI-I), CRI-II, atherogenic coefficient (AC) and atherogenic index of plasma (AIP), were found to be significant positively correlated with low density lipoprotein cholesterol (LDL) (r=0.923, p=0.0001, r=0.935, p=0.0001,r=0.970, p=0.0001 and r=0.382, p=0.0001 respectively). The ROC curve analysis of lipid indices for cardiometabolic risk reveals that AUC for CRI-I and AC was high and statistically significant than other lipid parameters.The present study suggests that in addition to routine lipid investigations the inclusion of lipid Indices especially CRI-I, AC, were better indices for screening of early detection of cardiometabolic risk in female patients with hypothyroidism.

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A study to assess the relation between severity of hypothyroidism and Lipid parameters

Cited by 2 publications

References 0 publications

Assessment of Serum Electrolyte in Hypothyroid Patients Attending Chitwan Medical College

Assessment of Serum Electrolyte in Hypothyroid Patients Attending Chitwan Medical College

Castelli risk index-1 and atherogenic coefficient are better predictors of cardiometabolic risk in patients with hypothyroidism

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