A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3across membranes

Bienert, Gerd Patrick; Thorsen, Michael; Schüssler, Manuela Désirée; Nilsson, R. Henrik; Wagner, Annemarie; Tamás, Markus J.; Jahn, Thomas P.

doi:10.1186/1741-7007-6-26

Cited by 376 publications

(270 citation statements)

References 59 publications

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“…[38,39] Similarly, owing to its structural similarities to phosphate, As V , in the form of AsO 4 3À , is known to be accumulated through phosphate transporters in E. coli, yeast and mammals. [40,41] Owing to this dependency on transporters that are designed for nutrients, the toxicity induced by the metalloids is highly dependent on nutrient exposure concentrations and conditions (Box 2).…”

Section: Introductionmentioning

confidence: 99%

When are metal complexes bioavailable?

Zhao¹,

Campbell²,

Wilkinson³

2016

Environ. Chem.

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Environmental context. The concentration of a free metal cation has proved to be a useful predictor of metal bioaccumulation and toxicity, as represented by the free ion activity and biotic ligand models. However, under certain circumstances, metal complexes have been shown to contribute to metal bioavailability. In the current mini-review, we summarise the studies where the classic models fail and organise them into categories based on the different uptake pathways and kinetic processes. Our goal is to define the limits within which currently used models such as the biotic ligand model (BLM) can be applied with confidence, and to identify how these models might be expanded.Abstract. Numerous data from studies over the past 30 years have shown that metal uptake and toxicity are often best predicted by the concentrations of free metal cations, which has led to the development of the largely successful free-ion activity model (FIAM) and biotic ligand model (BLM). Nonetheless, some exceptions to these classical models, showing enhanced metal bioavailability in the presence of metal complexes, have also been documented, although it is not yet fully understood to what extent these exceptions can or should be generalised. Only a few studies have specifically measured the bioaccumulation or toxicity of metal complexes while carefully measuring or controlling metal speciation. Fewer still have verified the fundamental assumptions of the classical models, especially when dealing with metal complexes. In the current paper, we have summarised the exceptions to classical models and categorised them into five groups based on the fundamental uptake pathways and kinetic processes. Our aim is to summarise the mechanisms involved in the interaction of metal complexes with organisms and to improve the predictive capability of the classic models when dealing with complexes.

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Section: Introductionmentioning

confidence: 99%

When are metal complexes bioavailable?

Zhao¹,

Campbell²,

Wilkinson³

2016

Environ. Chem.

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“…Members of the NIP (nodulin-26-like intrinsic proteins) and PIP (plasma membrane intrinsic proteins) subfamilies of aquaporins have been shown to facilitate AsIII transport in plants in Abbreviations NIPs, nodulin-26-like intrinsic proteins; RGR, relative growth rate; WT, wild-type. addition to transporting essential nutrients such as silicon and boron [7][8][9][10][11][12][13].…”

Section: Highlightsmentioning

confidence: 99%

Arabidopsis thaliana NIP7;1 is involved in tissue arsenic distribution and tolerance in response to arsenate

Lindsay

Maathuis

2016

FEBS Letters

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The Arabidopsis aquaglyceroporin NIP7;1 is involved in uptake and tolerance to the trivalent arsenic species arsenite. Here, we show that NIP7;1 is also involved in the response to pentavalent arsenate. Loss of function of NIP7;1 improved tolerance to arsenate and reduced arsenic levels in both the phloem and xylem, resulting in altered arsenic distribution between tissues. There was no clear correlation between growth and shoot arsenic concentration. This is the first report detailing the involvement of a NIP transporter in response to arsenate. The data suggest that these proteins are relevant targets for breeding and engineering arsenic tolerance in crops.

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“…TN-67) were germinated in distilled water for 3 days at 26 0 C in darkness. Once the roots reached 3-4cm in length, they were treated with different concentrations of AsV (Na 2 h, was extracted using of the RNAeasy Plant Mini Kit (QIAGEN, Hilden, Germany). cDNA was performed from 1µg of total RNA from each sample with a ImProm-II Reverse Transcription System (Promega, USA).…”

Section: A Plant Material Growth and Stress Conditionsmentioning

confidence: 99%

“…Both of inorganic forms are highly toxic and plants exposed to them show symptoms relating inhibited root growth, decreased photosynthetic rate and reduced in crop yield. As concentration in groundwater in many countries such as United State and Asians have reported excess 10 µg/l, the permissible limit by WHO [2]. Arsenic in the groundwater can be used for irrigation that enters to the food-chain through plant up take and consumption by animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Identification of Genes Related to Arsenic Detoxification in Rice Roots Using Microarray Analysis

Nguyen¹,

Huang²,

Huang³

2014

IJBBB

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Abstract-Arsenic(As) contamination in natural environment is a problem in many countries. Plants exposed to As show cytotoxic effects as inhibit cellular function, disrupt metabolism and reduce the yield. However, little is known about the molecular mechanisms of rice early expose to arsenate (AsV) at low concentration (10μM). Therefore, to better understand the molecular basis of rice cells, we performed a large-scale during analysis of the rice transcriptome within 24 hours challenged with AsV, one kind of common As inorganic species. In our microarray data, 614 transcripts were identified in response to AsV treatment. These transcripts related in plant defense mechanisms and the regulation of genes encoding to glutathione-S-transferase, oxidative stress, heat shock protein and enzymes in the ubiquitination pathway of protein degradation. Several important genes related to sulfate assimilation and GSH metabolism were induced for detoxification of As. Activities of peroxidase (POD) in rice roots increased after 12h and 24h treated to AsV, while the glutathione content at 12 h displayed decreasing trend but increasing trend after 24 h. Taken together, these data provide an overview of novel insights of AsV detoxification in rice and elicited for further investigation mechanism of arsenic detoxification in plants.

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A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3across membranes

Cited by 376 publications

References 59 publications

When are metal complexes bioavailable?

When are metal complexes bioavailable?

Arabidopsis thaliana NIP7;1 is involved in tissue arsenic distribution and tolerance in response to arsenate

Identification of Genes Related to Arsenic Detoxification in Rice Roots Using Microarray Analysis

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