A subset of mucosa-associated Escherichia coli isolates from patients with colon cancer, but not Crohn's disease, share pathogenicity islands with urinary pathogenic E. coli

Bronowski, Christina; Yokota, Kyoko; Corkill, J. E.; Martin, Helen; Campbell, Barry J.; Rhodes, Jonathan M.; Winstanley, Craig

doi:10.1099/mic.0.2007/013086-0

Cited by 37 publications

(29 citation statements)

References 54 publications

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“…53 E. coli is a mosaic of highly clonal genomic regions interspersed with areas with a high degree of recombination. 53 From this study and others, 11,12,15,[21][22][23] it is clear that AIEC share genes with extraintestinal E. coli, but MLST analysis 21 of clonal genes indicate unique sequence types that apparently have emerged to take advantage of an IBD microenvironment. To further elucidate the role of E. coli in the pathogenesis of IBD a better understanding of the population structure of AIEC is required and would be best achieved by whole genome sequencing.…”

Section: Discussionmentioning

confidence: 85%

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Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease

Sepehri¹,

Khafipour²,

Bernstein³

et al. 2011

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 85%

“…Recombination events were identified by FimH sequencing that may be a result of an IBD microenvironment. [21][22][23][24] …”

mentioning

confidence: 98%

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease

Sepehri¹,

Khafipour²,

Bernstein³

et al. 2011

Inflammatory Bowel Diseases

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“…In an AOM-treated IL-10 knockout mouse model, monocolonization with this strain promoted carcinoma formation [79]. Several pathogenicity islands present in 30-40 % of isolates from CRC patients were previously detected only in uropathogenic E. coli strains [80].…”

Section: Evidence For Correlations Of Microbiota With Crcmentioning

confidence: 99%

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

Culpepper¹,

Mai

2012

Curr Nutr Rep

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The contributions of the commensal gut microbiota to the maintenance of human health have long been contemplated. Whereas earlier studies were limited by an inability to analyze microbiota in sufficient depth, recent advances in the application of high throughput sequencing have allowed for an in-depth microbiota analysis in large numbers of individuals. Multiple lines of evidence have been generated that are supportive of an active role of gut microbiota in colorectal carcinogenesis. Although no single microbe has yet been shown to be causally linked to CRC, contributions of the gut microbiota to colorectal carcinogenesis are evident. Further advances in the field, which should include prospective studies in high-risk cohorts, should generate the data needed to start translating findings into microbiota-based screening and prevention regimen that can help to reduce the burden of CRC.

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“…These studies suggest that pks + strains of E. coli could be involved in the initiation and progression of CRC. As, E. coli is generally regarded as a normal commensal inhabitant of the gastro-intestinal tract, Bronowski and co-workers investigated the differences between E. coli strains collected from healthy individuals and CRC patients (Bronowski et al, 2008). These experiments showed that a subset of E. coli strains recovered from CRC tissue shared pathogenicity islands, encoding an alfa haemolysin and a cytotoxic necrotizing factor, with uropathogenic E. coli strains.…”

Section: Toxin-induced Dna Damagementioning

confidence: 99%