2009
DOI: 10.1021/am900718a
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A Substrate-Independent Approach for Bactericidal Surfaces

Abstract: Existing methods for imparting antibacterial performance to solid surfaces tend to either be substrate-specific or rely upon leaching modes of action that cause ecological damage. An alternative approach is outlined comprising plasmachemical functionalization of solid surfaces with poly(4-vinyl pyridine) moieties and their subsequent activation (quaternization) with bromobutane to yield bactericidal activity. These bioactive surfaces can be applied to a host of different substrate materials and are easily rege… Show more

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Cited by 29 publications
(19 citation statements)
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“…One potential approach for reducing the use of antibiotics is the introduction of antimicrobial surface coatings. Various antimicrobial materials have been investigated to develop antibiofouling surface coatings that have the ability to prevent the attaching of proteins, bacteria, or marine organisms [2][3][4][5][6][7][8][9]. However, many of the developed anti-biofouling coatings have failed in medical applications due to bacteria mutation and their ability to develop antibacterial resistance or because the employed anti-biofouling components are highly toxic and, therefore, not employable in medicine [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…One potential approach for reducing the use of antibiotics is the introduction of antimicrobial surface coatings. Various antimicrobial materials have been investigated to develop antibiofouling surface coatings that have the ability to prevent the attaching of proteins, bacteria, or marine organisms [2][3][4][5][6][7][8][9]. However, many of the developed anti-biofouling coatings have failed in medical applications due to bacteria mutation and their ability to develop antibacterial resistance or because the employed anti-biofouling components are highly toxic and, therefore, not employable in medicine [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…The inherent reactive nature of the electrical discharge ensures good adhesion to the underlying substrate via free radical sites created at the interface during ignition of the plasma. Previous examples of pulsed plasma deposited well‐defined functional films include poly(glycidyl methacrylate),27, 28 poly(bromoethyl‐acrylate),29 poly(vinyl aniline),30 poly(vinylbenzyl chloride),31 poly(allylmercaptan),32 poly( N ‐acryloylsarcosine methyl ester),33 poly(4‐vinyl pyridine),34 and poly(hydroxyethyl methacrylate) 35…”
Section: Introductionmentioning
confidence: 99%
“…The crude products were purified and analyzed by reversed-phase high-performance liquid chromatography (RP-HPLC) in an acetonitrile-water (Sigma Aldrich, Steinheim, Germany) gradient containing 0.1% TFA. The identity of the peptides was confirmed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF) and the counter-ion was determined by ion chromatography [71,72]. MS and HPLC analysis are included in Supplementary Materials.…”
Section: Peptide Synthesismentioning
confidence: 99%