A suplementação de creatina prejudica a função renal?

Creatine (Cr) Supplementation has been efficient and safely used as a therapeutic aid in many health and sickness conditions including muscle weakness, atrophy and metabolic disturbances. In Peripheral arterial obstructive disease (PAOD), chronic ischemia leads to muscle fiber atrophy and denervation, negative muscle metabolism alterations, thus reducing strength and endurance, impairing general physical fitness. Adding the studied benefits of Cr supplementation and the clinical frame of PAOD, it presents Cr Supplementation as a potential therapeutic aid to be considered. Objective: To make a systematic review in scientific literature, searching for studies involving Cr supplementation in PAOD individuals. Method: A search for Portuguese and English written articles, published over the last ten years, including terms related to PAOD and Cr supplementation, was conducted on PubMed SciELO, and LILACS. Results: Only one study evaluated the influence of Cr supplementation in the desired sample (PAOD), describing positive effects in walking distance and blood properties. Due to lack of scientific data, the use Cr supplementation in PAOD population, including metabolic, functional and structural considerations was discussed. Conclusion: Despite the presented discussion for using Cr supplementation in PAOD as a potential therapeutic aid, only one previous study could verify its benefits. Therefore, it still has a gap in scientific literature, leaving several possibilities for future studies researching for possible benefits to counteract the loss of functional fitness and impairments in musculoskeletal structure and metabolism of diseased individuals. Keywords: Creatine, Peripheral Arterial Disease/rehabilitation, Intermittent ClaudicationCreatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation Suplementação de creatina como potencial agente terapêutico na reabilitação da doença arterial obstrutiva periférica RESUMOSuplementação de Creatina (Cr) têm sido utilizada de forma segura e eficaz em diversas condições de saúde e doença, incluindo fraqueza, atrofia e distúrbios metabólicos musculares. Na Doença arterial obstrutiva periférica (DAOP), a isquemia crônica promove atrofia, denervação e prejuízos metabólicos musculares, reduzindo a força e resistência, prejudicando a aptidão física geral. Tomando em conjunto, os benefícios conhecidos da suplementação de Cr e a apresentação clínica da DAOP, apresentam a suplementação de Cr como potencial agente terapêutico a ser considerado. Objetivo: Realizar uma revisão sistemática da literatura científica procurando por estudos envolvendo a suplementação de Cr em portadores de DAOP, publicados nos últimos dez anos. Método: Uma pesquisa por artigos escritos em português e inglês no período descrito, incluindo o cruzamento de termos relacionados a DAOP e a suplementação de Cr foi realizada no PubMed, SciELO, e LILACS. Resultados: Um único estudo avaliou a influência da suplementação de Cr na amostra desejada (DAOP), de...

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“…In the end, Cr monohydrate has been the most studied supplement applied on sports performance enhancement and several health conditions. 4,5,58 …”

Section: Other Considerationsmentioning

confidence: 99%

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

2013

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“…However, due to its intense use as a nutritional supplement, it is necessary to conduct a careful evaluation on the possible toxicity to metabolism and liver morphology, as well as to renal function, as a result from such supplementation, since its toxicological effects are still controversial in scientific literature 30 . Studies have shown that creatine supplementation did not cause damage to kidney and liver function in rats 31,32 .…”

Section: Introductionmentioning

confidence: 99%

Study of renal and hepatic toxicity in rats supplemented with creatine

Baracho

Castro²,

Borges³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the renal and hepatic function, through biochemical analysis after 14 days of creatine supplementation in physically inactive rats. METHODS:Twenty four male, adult, Wistar rats were used which were kept in individual metabolic cages and were distributed into four groups, and received the following treatments by gavage:1) Control: distilled water; 2)Creatine 0.5g/Kg/day; 3) Creatine 1g/Kg/ day; 4) Creatine 2g/Kg/day. Their urinary outputs as well as food and water intake were daily measured. At the end of the experiment, the animals were euthanized and serum samples were stored for biochemical analysis. RESULTS:Creatine supplementation at the doses given produced no significant changes in plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, glucose, creatinine, urea, and creatinine clearance, compared to control group (p> 0.05) Similarly, water and food intake, as well as urinary output, did not show significant changes among the four groups studied. CONCLUSION:At the doses used, oral creatine supplementation did not result in renal and/or hepatic toxicity.

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“…Creatine supplementation has become popular from the Olympic Games of Barcelona in 1992 and is currently one of the most popular protein supplements used by athletes and physical activity practitioners (1,2) . There is evidence that the creatine amount stored may be the limiting factor of physical performance in high intensity and short duration exercises.…”

Section: Introductionmentioning

confidence: 99%

“…Shao and Hathcock (4) , after extensive work, verified that after two and a half decades of experimental and clinical studies with different dosage and times of supplementation, in only two cases of volunteers supplemented with creatine renal complication have been reported, but which came from periods previous to these experiments. However, despite the strong evidence of this substance as an ergogenic agent, it is still not unkown about possible hepatic and renal alterations derived from creatine supplementation, demanding hence further studies on this supplementation safety (2,5,6) . A hypothesis that creatine supplementation modifies the renal and hepatic functions in individuals clinically normal is brought about from the shortage of evidence on the potential adverse effects derived from the supplementation with monohydrate creatine in the hepatic and renal function.…”

Section: Introductionmentioning

confidence: 99%

Suplementação com creatina associada ao treinamento resistido não altera as funções renal e hepática

Carvalho

Molina

Fontana

2011

Rev Bras Med Esporte

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Creatine is the most popular nutritional supplement widely used to improve performance in activities that involve exercise of short duration and high intensity. However, the complications arising from its use are not fully elucidated. The aim of this study was to evaluate the effects of two doses of creatine supplementation on renal and hepatic function in healthy adults during eight weeks of resistance exercise training. Biochemical tests were performed on 35 athletes randomly distributed into three groups, placebo (PLA, n = 12), creatine (CRE1, n = 12) and creatine2 (CRE2, n = 11) before and after eight weeks of resistance training. In a double-blind design, the volunteers were supplemented (20 g/day) with creatine (CRE1, CRE2) or placebo (PLA) for seven days and at the 53 subsequent days with 0.03g/kg of body weight of each supplement (CRE1, PLA) and 5g/day for CRE2. There was no intervention in the composition of their diets, which were recorded and analyzed. The results of biochemical tests conducted remained within normal ranges. Creatinine values increased by 12.2% for CRE1 and 9.0% for CRE2, whereas decreased by 4.7% in PLA; however, these values did not exceed normal rates. The values of liver function tests declined in nearly all fractions in all treatments, not being statistically significant, though. It is concluded that creatine supplementation at the dosages used (0.03g/kg and 5g/day) for healthy subjects during eight weeks does not alter hepatic or renal function, hence under the conditions of this study, creatine was considered safe.

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A suplementação de creatina prejudica a função renal?

Cited by 16 publications

References 30 publications

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

Study of renal and hepatic toxicity in rats supplemented with creatine

Suplementação com creatina associada ao treinamento resistido não altera as funções renal e hepática

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