As one of the common methods to construct classifiers, naïve Bayes has become one of the most popular classification methods because of its solid theoretical basis, strong prior knowledge learning characteristics, unique knowledge expression forms, and high classification accuracy. This classification method has a symmetry phenomenon in the process of data classification. Although the naïve Bayes classifier has high classification performance in single-label classification problems, it is worth studying whether the multilabel classification problem is still valid. In this paper, with the naïve Bayes classifier as the basic research object, in view of the naïve Bayes classification algorithm’s shortage of conditional independence assumptions and label class selection strategies, the characteristics of weighted naïve Bayes is given a better label classifier algorithm framework; the introduction of cultural algorithms to search for and determine the optimal weights is proposed as the weighted naïve Bayes multilabel classification algorithm. Experimental results show that the algorithm proposed in this paper is superior to other algorithms in classification performance.