A survey of the amount of pristane in common fruits and vegetables

Chung, J. G.; Garrett, Lenora R.; Byers, P. E.; Cuchens, Marvin A.

doi:10.1016/0889-1575(89)90058-6

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…For example, pristane reduces growth of trout [8], causes arthritis in mice [9], depresses the immune system of mice [10], and increases production of growth factors ]11]. Given the fact that pristane is present in many common foods and vegetables [12] as well as tissues of animals [13], it is conceivable pristane may play a role in the development of some human cancers.…”

Section: Introductionmentioning

confidence: 99%

The tumor promoter pristane activates transcription by a cAMP dependent mechanism

1992

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Pristane is a naturally occurring isoprenoid which is believed to be derived from the phytyl moiety of chlorophyll. Thus it is not surprising that pristane is present in many common fruits or vegetables and furthermore can be detected in tissues of fish and mammals. Using the rat as an animal model, pristane can function as a potent tumor promoter. It is conceivable that pristane could play a role in the development of certain malignancies in higher mammals since it is commonly found in the diet. At the molecular level, pristane can induce changes in the plasma membrane, alter the conformation of chromatin, as well as selectively activate gene expression. This study was undertaken to identify specific transcriptional motifs which are responsive to pristane. A transcriptional promoter which contained a cAMP response element (CRE) was consistently stimulated by pristane in several mouse and primate cell lines. A promoter construct which contained a single copy of the TPA response element (TRE) was also activated by pristane but surprisingly a promoter which contained multiple copies of the TRE was not. Activation of the TRE required 10 fold higher concentrations of pristane relative to activation of the CRE. Within two hours after addition of pristane to monkey fibroblasts (CV-1) levels of cAMP were increased more than two fold relative to controls. These data indicated that pristane can increase the level of cAMP in CV-1 cells and consequently stimulate transcriptional promoters which contain a CRE.

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Section: Introductionmentioning

confidence: 99%

The tumor promoter pristane activates transcription by a cAMP dependent mechanism

1992

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“…The biological relevance of the effects of pristane observed to date pertains to the fact that pristane is a ubiquitous isoprenoid derived from chlorophyll and is present in appreciable amounts in our common foodstuffs [20]. The purpose of the studies presented below was to further examine the effects of pristane on lymphoid cells and more specifically to address the possible mechanism whereby pristane elicits a change in chromatin conformation.…”

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confidence: 98%

Pristane induced effects on chromatin of rat lymphoid cells

Garrett

Cuchens

1991

J of Cellular Biochemistry

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The effects of pristane on the conformation of chromatin in cells isolated from the lymphoid tissues of pristane-treated Copenhagen rats were examined by flow cytometry, thermal denaturation, sensitivity to enzymatic digestion, and histone protein analyses. Decreases were observed in the fluorescent intensities of propidium iodide (PI) stained nuclei isolated from lymphoid cells of pristane-treated rats when compared with normal rat lymphoid nuclei. Studies to address the possible basis for the pristane-induced changes in the DNA staining characteristics of lymphocytes demonstrated that 1) there were no decreases in the amount of DNA present in the nuclei, 2) nuclei isolated from pristane treated rats were less sensitive to thermal denaturation, as well as DNase I enzymatic digestion, and 3) there were apparent increases in the expression of the H1 histone proteins. Collectively, these results suggest that pristane elicits a conformational change in the chromatin which may be mediated by altered expression of nuclear-associated histone proteins.

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“…The use of mineral oil and other paraffinoids is widespread in medications (e.g., laxatives, nose drops, petroleum jelly, baby oils), as a protective coating for foods (e.g., apples, cucumbers, cheese), for food packaging (e.g., milk, baked goods), and as a lubricant in baking (13,17,55,56). The average diet in the United States contains 47.5 g of mineral oil annually (57,58).…”

Section: Pristane-treated Micementioning

confidence: 99%

Immunopathogenesis of environmentally induced lupus in mice.

Shaheen

Satoh

Richards

et al. 1999

Environ Health Perspect

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Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome defined by clinical and serologic features, including arthritis, glomerulonephritis, and certain autoantibodies such as anti-nuclear ribonucleoprotein (nRNP)/Smith antigen (Sm), DNA, and ribosomal P. Although lupus is considered primarily a genetic disorder, we recently demonstrated the induction of a syndrome strikingly similar to spontaneous lupus in many nonautoimmune strains of mice exposed to the isoprenoid alkane pristane (2,6,10,14-tetramethylpentadecane), a component of mineral oil. Intraperitoneal injection of pristane leads to the formation of lipogranulomas consisting of phagocytic cells that have engulfed the oil and collections of lymphocytes. Subsequently, pristane-treated BALB/c and SJL mice develop autoantibodies characteristic of SLE, including anti-nRNP/Sm, antiribosomal P, anti-Su, antichromatin, anti-single-stranded DNA, and anti-double-stranded DNA. This is accompanied by a severe glomerulonephritis with immune complex deposition, mesangial or mesangiocapillary proliferation, and proteinuria. All inbred mice examined appear to be susceptible to this novel form of chemically induced lupus. Pristane-induced lupus is the only inducible model of autoimmunity associated with the clinical syndrome as well as with the characteristic serologic abnormalities of SLE. Defining the immunopathogenesis of pristane-induced lupus in mice may provide insight into the causes of spontaneous (idiopathic) lupus and also may lead to information concerning possible risks associated with the ingestion or inhalation of mineral oil and exposure to hydrocarbons in the environment. Images Figure 1 Figure 2 Figure 3

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A survey of the amount of pristane in common fruits and vegetables

Cited by 12 publications

References 24 publications

The tumor promoter pristane activates transcription by a cAMP dependent mechanism

The tumor promoter pristane activates transcription by a cAMP dependent mechanism

Pristane induced effects on chromatin of rat lymphoid cells

Immunopathogenesis of environmentally induced lupus in mice.

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