A systematic review of <i>Gymnema sylvestre</i> in obesity and diabetes management

Nowadays, studies about the anti‐obesity potential of probiotics are of growing interest. Lactobacilli are one of the well‐studied probiotics owing to their preventing effect on metabolic disorders. This study was undertaken to access the anti‐obesity effect of probiotic dahi containing Lactobacillus casei NCDC 19 on C57BL/6 mice. Feeding of probiotic dahi showed reduce body weight gain and epididymal fat weights. Moreover, blood glucose, plasma lipids and expression level of leptin were reduced and caecal bifidobacteria counts and adiponectin expression levels were significantly increased. It can be concluded that feeding of probiotic dahi containing L. casei NCDC 19 showed potential anti‐obesity effects.

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“…More than one billion and 300 million people are considered to be overweight and obese, respectively (Pothuraju et al . ).…”

Section: Introductionmentioning

confidence: 97%

Anti‐obesity effect of feeding probiotic dahi containing Lactobacillus casei NCDC 19 in high fat diet‐induced obese mice

Rather

Pothuraju

Sharma

et al. 2014

Int J of Dairy Tech

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“…These circulatory FFAs further accumulate in several organs (liver, kidney, and muscle), and the development of IR occurs mostly in the muscle tissue. Recent reports suggested that more than 300 and 439 million people are considered to be obese and diabetic, respectively (Pothuraju et al , ).…”

Section: Introductionmentioning

confidence: 97%

Hypoglycemic and Hypolipidemic Effects ofAloe veraExtract Preparations: A Review

Pothuraju¹,

Sharma²,

Onteru³

et al. 2015

Phytother. Res.

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Obesity is considered to be an epidemic disease, and it is associated with several metabolic disorders. Pharmacological treatments currently available are not effective for prolonged treatment duration. So, people are looking toward new therapeutic approach such as herbal ingredients. Since ancient periods, different herbs have been used for remedy purposes such as anti-obesity, antidiabetes, and antiinflammatory. Among the several herbal ingredients, Aloe vera (Aloe barbadensis Miller) is widely used to curb the metabolic complications. Till date, reports are not available for the side effects of A. vera. Several researchers are used to different solvents such as aqueous solution, alcohol, ethanol, and chloroform for the A. vera extract preparations and studied their hypoglycemic and hypolipidemic effects in animal and human studies. Furthermore, little information was recorded with the active compounds extracted from the A. vera and their anti-obesity and antidiabetic effects in clinical studies. In this review, we made an attempt to compile all the available literature by using different search engines (PubMed, Scopus, and Google Scholar) on the A. vera extract preparations and the possible mechanism of action involved in carbohydrate and lipid metabolism.

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“…R. Br. (Family: Asclepiadaceae) is a woody climbing shrub that has medicinal value because of the presence of various bioactive compounds like gymnemic acids (GA) and phenolic compounds (PC), which are used to treat diabetes mellitus [1]. The plant is also used as an ingredient of tea, confections, and many food preparations for the regulation of sugar homeostasis and to control obesity and the level of blood cholesterol [2].…”

Section: Introductionmentioning

confidence: 99%

Impact of Copper Oxide Nanoparticles on Enhancement of Bioactive Compounds Using Cell Suspension Cultures of Gymnema sylvestre (Retz.) R. Br

et al. 2019

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Gymnema sylvestre is a plant that is enriched in bioactive compounds. In particular, gymnemic acids (GA) and phenolic compounds (PC) are pharmaceutically important. There is a commercial demand for naturally occurring bioactive compounds, but their availability is limited due to geographical and seasonal variations. The elicitation approach can enhance the biosynthesis of phytochemicals during in vitro culture of G. sylvestre. Here, to further improve gymnemic acid II (GA II) and phenolic compounds (PC) production by G. sylvestre, cell suspension cultures (CSC), which has attracted attention for the production of essential phytochemicals, was explored using copper oxide nanoparticles (CuO NPs). Callus was obtained on MS medium containing 2,4-dichlorophenoxyacetic acid, kinetin, phytoagar, and sucrose. Agar-free MS medium was used to initiate CSC, which was treated with three concentrations of CuO NPs (1, 3 or 5 mg/L). Treatment for 48 h with 3 mg/L CuO NPs resulted in the greatest yields of GA II, total phenolics, and flavonoids. The cultures also displayed pronounced antioxidant, antidiabetic, anti-inflammatory, antibacterial, antifungal, and anticancer activities. The use of CuO NPs (3 mg/L) significantly increased the production of GA II (nine-fold) and PC compared to unamended CSC. We propose that CSC and use of nanoparticles (NPs) as a new generation of elicitors, offer a suitable prospect for the production of bioactive compounds.

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A systematic review of Gymnema sylvestre in obesity and diabetes management

Cited by 90 publications

References 37 publications

Anti‐obesity effect of feeding probiotic dahi containing Lactobacillus casei NCDC 19 in high fat diet‐induced obese mice

Anti‐obesity effect of feeding probiotic dahi containing Lactobacillus casei NCDC 19 in high fat diet‐induced obese mice

Hypoglycemic and Hypolipidemic Effects ofAloe veraExtract Preparations: A Review

Impact of Copper Oxide Nanoparticles on Enhancement of Bioactive Compounds Using Cell Suspension Cultures of Gymnema sylvestre (Retz.) R. Br

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