A systematic review of myeloid leukemias and occupational pesticide exposure

Maele-Fabry, Geneviève Van; Duhayon, Sophie; Lison, Dominique

doi:10.1007/s10552-007-0122-2

Cited by 78 publications

(48 citation statements)

References 47 publications

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“…Indeed, in a recent systematic review, Van MaeleFabry et al [79] have found an increased risk of myeloid leukemia upon pesticide occupational exposure. In addition, prior meta-analysis [80,81] showed a relationship between farming and the occurrence of multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Merhi¹,

Raynal²,

Cahuzac³

et al. 2007

Cancer Causes Control

159

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The overall meta-odds ratio suggests that there is a significantly positive association between occupational exposure to pesticides and all hematopoietic cancers as well as NHL. A major limitation of our meta-analysis is the lack of sufficient data about exposure information and other risk factors for hematopoietic cancer (genetic predisposition, ethnic origin, immunodepression...). In addition, data concerning specific subtypes of hematopoietic cancers are often confusing. Thus, future epidemiological studies should undertake a major effort to assess the identity and the level of pesticides exposure and should control for the most likely potential confounders.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Merhi¹,

Raynal²,

Cahuzac³

et al. 2007

Cancer Causes Control

159

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“…ORs and CIs are 2 commonly used estimators in most meta-analyses dealing with health risks associated with environmental chemical exposures. 12,13,15,[17][18][19][20][21] The results were compared and consensus was obtained before the meta-analysis.…”

Section: Data Extractionmentioning

confidence: 99%

Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis

et al. 2015

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CONTEXT: There is an increasing concern about chronic low-level pesticide exposure during childhood and its influence on childhood cancers. OBJECTIVE:In this meta-analysis, we aimed to examine associations between residential childhood pesticide exposures and childhood cancers. DATA SOURCES:We searched all observational studies published in PubMed before February 2014 and reviewed reference sections of articles derived from searches.STUDY SELECTION: The literature search yielded 277 studies that met inclusion criteria.DATA EXTRACTION: Sixteen studies were included in the meta-analysis. We calculated effect sizes and 95% confidence intervals (CIs) by using a random effect model with inverse variance weights. RESULTS:We found that childhood exposure to indoor but not outdoor residential insecticides was associated with a significant increase in risk of childhood leukemia (odds ratio [OR] = 1.47; 95% CI, 1.26-1.72; I 2 = 30%) and childhood lymphomas (OR = 1.43; 95% CI, 1.15-1.78; I 2 = 0%). A significant increase in risk of leukemia was also associated with herbicide exposure (OR = 1.26; 95% CI, 1.10-1.44; I 2 = 0%). Also observed was a positive but not statistically significant association between childhood home pesticide or herbicide exposure and childhood brain tumors. LIMITATIONS:The small number of studies included in the analysis represents a major limitation of the current analysis. CONCLUSIONS:Results from this meta-analysis indicated that children exposed to indoor insecticides would have a higher risk of childhood hematopoietic cancers. Additional research is needed to confirm the association between residential indoor pesticide exposures and childhood cancers. Meanwhile, preventive measures should be considered to reduce children's exposure to pesticides at home.

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“…Otros efectos de la exposición crónica a plaguicidas que presentan una contundente evidencia son las enfermedades neurológicas, como Parkinson, esclerosis lateral amiotrófica y Alzheimer(12,24-28) y el desarrollo de algunos tipos de cáncer como leucemia, cáncer de próstata y el linfoma de Hodgkin (12,(29)(30)(31)(32)(33)(34)(35). Las investigaciones han encontrado que existe un mayor riesgo de presentar estas enfermedades si se vive en áreas rurales, se bebe de agua de pozo y se trabaja en actividades agrícolas.…”

Section: El Problema Histórico De Los Plaguicidasunclassified

“…Los resultados concluyen, en una primera instancia, que los niveles de residuos de plaguicidas en vegetales de consumo nacional estarían dentro de la normativa vigente del MINSAL para esa épo-ca (1,33). Sin embargo, si se revisan detenidamente los datos, se puede observar que el 63% de las frutas y verduras consumidas en Chile contienen residuos de plaguicidas muy peligrosos.…”

Section: Efectos De Los Plaguicidas En La Poblaciónunclassified

Aspectos bioéticos en el control y aplicación de plaguicidas en Chile

Quezada

Teresa²

2011

Acta bioeth.

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Resumen: En Chile, la venta y aplicación de plaguicidas ha ido en aumento, y si bien existen normativas sobre su importación, comercialización, control y aplicación, estas no son efectivas en la regulación del su uso por la población, sobre todo no ocupacional. El Senado chileno rechazo un proyecto de ley que prohibía el uso de los plaguicidas considerados a nivel mundial como altamente peligrosos, lo que ha derivado en un fuerte reclamo de organizaciones no gubernamentales y comunidades agrícolas expuestas a estos tóxicos, señalando errores en los procesos de legislación de los agroquímicos y desinformación sobre los efectos y riesgos de toxicidad principalmente crónica en quienes se ven expuestos a los pesticidas. El siguiente trabajo discute la escasa preocupación bioética de parte de las autoridades y la ciudadanía por los efectos que están generando los pesticidas en la población y el medio ambiente, reveladas en la continuidad de la comercialización y aplicación de plaguicidas de elevada toxicidad, y en la presencia de residuos de pesticidas en los productos vegetales que se comercializan a nivel nacional.Palabras clave: bioética, control de plaguicidas, salud de la población Bioethical aspects of control and application of pest control substances in ChileAbstract: In Chile, pest control substances selling and application is increasing, and although there are regulations about importation, commercialization, control and application, these are not effective in the regulation of their use by the population, mainly no occupational. Chilean Senate rejected a bill which prohibits the use of pest control substances considered highly dangerous worldly, what has led to strong claims of nongovernmental organizations and agricultural communities exposed to these toxics, highlighting errors in the legislation process for agro chemists and lack of information about effects and risks of toxicity, mainly chronic for those exposed to pest control substances. This study discuss the scarce bioethics concern by authorities and citizens about the effects being generated by pest control substances in the population and the environment, revealed in the continuity of commercialization and application of highly toxic pest control substances, and in the presence of pest control residues in vegetable products commercialize at national level. Key words: bioethics, pest control substances control, population health Aspectos bioéticos no controle e na aplicação de praguicidas no ChileResumo: No Chile, a venda e aplicação de praguicidas tem tido aumento, e se bem existem normas sobre sua importação, comercialização, controle e aplicação, estas não são efetivas na regulação do seu uso pela população, sobretudo não ocupacional. O Senado chileno recusou um projeto de lei que proibia o uso dos praguicidas considerados em nivel mundial como altamente perigosos, o que derivou forte reclamação de organizações não governamentais e comunidades agrícolas expostas a estes tóxicos, assinalando erros nos processos de legislação dos agroquímicos e ...

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A systematic review of myeloid leukemias and occupational pesticide exposure

Abstract: The strongest evidence of an increased risk of ML comes from manufacturing workers and pesticide applicators. Further studies will be needed to correlate reliable exposure data within these specific occupational groups with well-defined subtypes of leukemia to refine this assessment.

Cited by 78 publications

References 47 publications

Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis

Aspectos bioéticos en el control y aplicación de plaguicidas en Chile

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