A systematic review of the safety and effectiveness of platelet-rich plasma (PRP) for skin aging

Maisel-Campbell, Amanda; Ismail, Aliaa; Reynolds, Kelly A.; Poon, Emily; Serrano, Linda; Grushchak, Solomiya; Farid, Carmen; West, Dennis P.; Alam, Murad

doi:10.1007/s00403-019-01999-6

Cited by 87 publications

(90 citation statements)

References 45 publications

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“…A positive correlation between PRP and skin anti-aging has also been reported in both pre-clinical and clinical practice (25)(26)(27)(28). Consistent with previous studies (17,26), the present clinical study showed that PRP treatment improved skin conditions, including increased skin thickness, enhanced collagen content and reduced pigmentation. In addition, parameters assessed using the VISIA system, such as wrinkles, texture and pores were all decreased compared with pretreatment.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, PRP also contains a large number of cell adhesion proteins, such as cellulose, fibronectin and vitronectin, that may keep skin smooth and tight (24). Physiologically, the growth factors in PRP have important roles in reducing the rate of aging by restoring the declining DNA synthesis that occurs with aging, resisting cell death and enhancing gene expression for tissue repair (25,26). A positive correlation between PRP and skin anti-aging has also been reported in both pre-clinical and clinical practice (25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

“…Physiologically, the growth factors in PRP have important roles in reducing the rate of aging by restoring the declining DNA synthesis that occurs with aging, resisting cell death and enhancing gene expression for tissue repair (25,26). A positive correlation between PRP and skin anti-aging has also been reported in both pre-clinical and clinical practice (25)(26)(27)(28). Consistent with previous studies (17,26), the present clinical study showed that PRP treatment improved skin conditions, including increased skin thickness, enhanced collagen content and reduced pigmentation.…”

Section: Discussionmentioning

confidence: 99%

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Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Lei

2020

Exp Ther Med

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Autologous serum platelet-rich plasma (PRP) has been used to rejuvenate wrinkled and aged skin for years; however, the molecular mechanism for the positive effects of PRP on the skin remains unclear. The present study aimed to clarify the potential molecular mechanisms for the role of PRP in wrinkled and aged skin rejuvenation, and provide evidence for future clinical applications. A total of 30 healthy females were recruited for PRP treatment and signed informed consent was obtained. A total of 3 autologous PRP injections were administered to each patient with 15-day intervals between injections. The effects of PRP injections were evaluated using the VISIA ® Complexion Analysis System and skin computed tomography. A human organotypic skin model was established and treated with PBS or PRP before ultraviolet (UV)-B light (10 mJ/cm 2) irradiation. The distribution of the epidermal structure and dermal fibers were analyzed by hematoxylin and eosin and Masson's trichome staining. Expression of matrix metalloproteinase-1 (MMP-1), tyrosinase, fibrillin and tropoelastin was detected by reverse transcription-quantitative PCR, western blotting and immunofluorescence. The present results showed that PRP treatment improved skin quality in the participants. In addition, the VISIA ® results showed that wrinkles, texture and pores were decreased in the PRP groups compared with the PBS treatment. The in vitro study demonstrated that PRP treatment ameliorated photoaging by inhibiting UV-B-induced MMP-1 and tyrosinase upregulation, and by inducing fibrillin and tropoelastin expression that was downregulated by UV-B. Collectively, it was demonstrated that PRP treatment ameliorated skin photoaging through regulation of MMP-1, tyrosinase, fibrillin and tropoelastin expression.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Lei

2020

Exp Ther Med

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“…[8][9][10][11] For facial skin aging, PRP use is associated with modest improvement in facial skin appearance, skin texture, and lines. 12 However, the clinical evidence for PRP use in this indication is limited by heterogeneity in the preparation and administration techniques used, and lack of standardization in outcome measures. 12 Despite the widespread use of PRP, concerns have been raised about the use of thrombin and anticoagulants that can impair wound healing by inhibiting the coagulation process.…”

Section: Introductionmentioning

confidence: 99%

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Hassan

Quinlan

Ghanem

2020

J of Cosmetic Dermatology

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“…The ideal platelet concentration is 2‐4 times over baseline, and with a concentration in this range, the highest secretion of endogenous hyaluronic acid was described for skin fibroblasts 47 . These actions can have a positive effect on skin quality and may contribute to a decrease in visible signs of skin aging 48 . The effect of transforming growth factor β in platelet granules may be responsible for decreased melanin production 49 …”

Section: Treatment Optionsmentioning

confidence: 99%

Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review

Kassir

Kroumpouzos

Puja³

et al. 2020

J of Cosmetic Dermatology

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Background The periorbital region is among the first areas to be affected by the process of aging, which is influenced by genetic and constitutional factors. As the region plays an important role in overall facial appearance, rejuvenation of the area has immense cosmetic benefit and various treatment modalities have been used to achieve the same. Aims This article reviews commonly used non‐surgical and minimally invasive modalities for periorbital rejuvenation. Methods The literature research considered published journal articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) and reference lists of respective articles. Only articles available in English were considered for this review. Results Autologous platelet rich plasma (PRP) is increasingly used in dermatology for skin and hair conditions. The use of PRP is rapidly growing in popularity as a modality to achieve skin rejuvenation. The mechanism by which PRP leads to skin rejuvenation is by increasing the dermal fibroblast proliferation, expression of matrix metalloproteinase and collagen synthesis. Conclusion The evidence discussed in this article indicates the increasing importance of minimally invasive modalities in periorbital rejuvenation and a promising role for PRP as solo therapy or in multimodality regimens.

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A systematic review of the safety and effectiveness of platelet-rich plasma (PRP) for skin aging

Cited by 87 publications

References 45 publications

Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review

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