A systematic review of the public's knowledge and beliefs about antibiotic resistance

McCullough, Amanda; Parekh, Sanjoti; Rathbone, John; Mar, Chris Del; Hoffmann, Tammy

doi:10.1093/jac/dkv310

Cited by 199 publications

(204 citation statements)

References 22 publications

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“…26 Beliefs about the need for antibiotics for acute otitis media were different from those for sore throat and cough, suggesting a role for clinicians in carefully eliciting perceptions and misperceptions that parents might have and tailoring their communication accordingly. 27,28 About one-half of parents reported antibiotic resistance as a potential harm, similar to proportions found in other cross-sectional studies, 21,28,29 although there was confusion among many about what resistance actually was, as has been reported by others. 18,25,29 Fewer parents mentioned common antibiotic harms consistent with empirical evidence, such as diarrhea and candidiasis 30 , and some of the complications that parents nominated as being reduced by antibiotic use are not clearly supported by evidence from randomized trials.…”

supporting

confidence: 69%

“…27,28 About one-half of parents reported antibiotic resistance as a potential harm, similar to proportions found in other cross-sectional studies, 21,28,29 although there was confusion among many about what resistance actually was, as has been reported by others. 18,25,29 Fewer parents mentioned common antibiotic harms consistent with empirical evidence, such as diarrhea and candidiasis 30 , and some of the complications that parents nominated as being reduced by antibiotic use are not clearly supported by evidence from randomized trials. Parents reported widespread use of alternatives to antibiotics in line with previous findings, 18,23 most of which have no or weak empirical evidence of efficacy, 31,32 with the exceptions being analgesics and antipyretics, and honey for cough.…”

supporting

confidence: 69%

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Parents’ Expectations and Experiences of Antibiotics for Acute Respiratory Infections in Primary Care

2017

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PURPOSE Primary care visits for children with acute respiratory infections frequently result in antibiotic prescriptions, although antibiotics have limited benefits for common acute respiratory infections and can cause harms, including antibiotic resistance. Parental demands are often blamed for antibiotic prescription. We aimed to explore parents' beliefs about antibiotic necessity, quantify their expectations of antibiotic benefit, and report experiences of other management options and exposure to and preferences for shared decision making.

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supporting

confidence: 69%

supporting

confidence: 69%

Parents’ Expectations and Experiences of Antibiotics for Acute Respiratory Infections in Primary Care

2017

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“…Although the recognition of the term “antibiotic resistance” has increased, the understanding of how to avoid it and how it is caused has not been translated as effectively. 15 Only by actively combining scientific innovation and communication can we avoid a postantibiotic era.…”

Section: Discussionmentioning

confidence: 99%

Natural Products as Platforms To Overcome Antibiotic Resistance

2017

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Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrowspectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.

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“…[1][2][3][4][5][6][7] b-Lactamases and b-lactam antibioticsa re key players in this emerging epidemic: b-lactams are amongst the most widelyu sed and best understood classes of antibiotics, b-lactamases pose an ever-increasing threat to their continuede fficacya st hey hydrolyse b-lactams before they can exert an antibiotic effect. [1][2][3][4][5][6][7] b-Lactamases and b-lactam antibioticsa re key players in this emerging epidemic: b-lactams are amongst the most widelyu sed and best understood classes of antibiotics, b-lactamases pose an ever-increasing threat to their continuede fficacya st hey hydrolyse b-lactams before they can exert an antibiotic effect.…”

Section: Introductionmentioning

confidence: 99%

Cyclobutanone Analogues of β‐Lactam Antibiotics: β‐Lactamase Inhibitors with Untapped Potential?

Devi

Rutledge

2017

ChemBioChem

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β-Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to β-lactams: the prolonged, widespread (and at times reckless) use of these drugs has spawned widespread resistance, which renders them ineffective against many bacterial strains. The cyclobutanone ring system is isosteric with β-lactam: in cyclobutanone analogues, the eponymous cyclic amide is replaced with an all-carbon ring, the amide N is substituted by a tertiary C-H α to a ketone. Cyclobutanone analogues of various β-lactam antibiotics have been investigated over the last 35 years, initially as prospective antibiotics in their own right and inhibitors of the β-lactamase enzymes that impart resistance to β-lactams. More recently they have been tested as inhibitors of other serine proteases and as mechanistic probes of β-lactam biosynthesis. Cyclobutanone analogues of the penam ring system are the first reversible inhibitors with moderate activity against all classes of β-lactamase; other compounds from this family inhibit Streptomyces R61 dd-carboxypeptidase/transpeptidase, human neutrophil elastase and porcine pancreatic elastase. But has their potential as enzyme inhibitors been fully exploited? Challenges in synthesising diversely functionalised cyclobutanone derivatives mean that only a limited number have been made (with limited structural diversity) and evaluated. This review surveys the different synthetic approaches that have been taken to these compounds, the investigations made to evaluate their biological activity and prospects for future developments in this area.

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A systematic review of the public's knowledge and beliefs about antibiotic resistance

Cited by 199 publications

References 22 publications

Parents’ Expectations and Experiences of Antibiotics for Acute Respiratory Infections in Primary Care

Parents’ Expectations and Experiences of Antibiotics for Acute Respiratory Infections in Primary Care

Natural Products as Platforms To Overcome Antibiotic Resistance

Cyclobutanone Analogues of β‐Lactam Antibiotics: β‐Lactamase Inhibitors with Untapped Potential?

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