A Systematic Review of the Effects of Neuromodulation on Eating and Body Weight: Evidence from Human and Animal Studies

McClelland, Jessica; Bozhilova, Natali; Campbell, Iain C.; Schmidt, Ulrike

doi:10.1002/erv.2256

Cited by 104 publications

(109 citation statements)

References 126 publications

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“…Previous studies provide evidence of positive effects of neuromodulation techniques (i.e., repetitive transcranial magnetic stimulation [rTMS]) on eating disorder symptomatology in individuals with bulimic-type eating disorders. [51][52][53] Repetitive transcranial magnetic stimulation of the dorsolateral PFC in individuals with bulimic-type eating disorders resulted in lower cue-induced food cravings and could therefore reduce binge eating. A recently published study reported rTMSinduced decreases in cerebral oxygenation of the left dorsolateral PFC in patients with bulimia nervosa using near-infrared spectroscopy.…”

Section: Discussionmentioning

confidence: 99%

Neural signature of behavioural inhibition in women with bulimia nervosa

Skunde

Walther

Simon

et al. 2016

jpn

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Section: Discussionmentioning

confidence: 99%

Neural signature of behavioural inhibition in women with bulimia nervosa

Skunde

Walther

Simon

et al. 2016

jpn

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“…EDs are characterized by altered self-image and maladaptive eating behaviors, and include AN, bulimia nervosa (BN) and binge-eating disorder (BED; McClelland et al, 2013). In recent years, functional imaging studies of EDs have pinpointed the intersection of cognitive and reward systems as integral to eating behavior regulation (Val-Laillet et al, 2015).…”

Section: Abnormalities Of Sn-cstc Loop Circuits In Psychiatric Illnessesmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

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The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the network’s associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. The SN’s cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of psychiatric illnesses and their available treatments. Functional imbalances within the SN loop appear to impair cognitive control, and specifically may impair self-regulation of cognition, behavior and emotion, thereby leading to symptoms of psychiatric illness. Furthermore, treating such psychiatric illnesses using invasive or non-invasive brain stimulation techniques appears to modulate SN cortical-subcortical loop integrity, and these effects may be central to the therapeutic mechanisms of brain stimulation treatments in many psychiatric illnesses. Here, we review clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED). We also review emergent therapeutic evidence that novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop, thereby restoring the capacity for cognitive control. Finally, we consider a series of promising directions for future investigations on the role of SN cortico-striatal-thalamic loop circuits in the pathophysiology and treatment of psychiatric disorders.

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“…Interestingly, prefrontal regions showed also different food-related activity depending on individual differences in reward drive, emotional eating style and cognitive restraint of eating (Beaver et al, 2006;Blechert, Goltsche, Herbert, & Wilhelm, 2013;Hollmann et al, 2012); finally, the activation of the prefrontal cortex differed when healthy volunteers were compared to participants with eating disorders such as obesity or anorexia (Martin et al, 2010;Uher et al, 2004). These results have led researchers to consider the prefrontal cortex as part of a neural circuit contributing to the pathophysiology of eating disorders (Kaye, Wagner, Fudge, & Paulus, 2011) and therefore an interesting candidate as cortical target for studies aiming at exploring the modulatory effects of non-invasive brain stimulation techniques on food-related behaviour (McClelland, Bozhilova, Campbell, & Schmidt, 2013). Indeed, medial and dorsolateral prefrontal cortices have been selected as target sites in studies with transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) showing that stimulation sessions reduced food craving in healthy participants (Fregni et al, 2008;Goldman et al, 2011;Uher et al, 2005) and pathological feelings and behaviour in participants with eating disorders (Downar, Sankar, Giacobbe, Woodside, & Colton, 2012;Van den Eynde et al, 2010;Van den Eynde, Guillaume, Broadbent, Campbell, & Schmidt, 2013).…”

Section: Introductionmentioning

confidence: 96%