A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

Groger, Mirjam; Fischer, Hannah; Veletzky, Luzia; Lalremruata, Albert; Ramharter, Michael

doi:10.1186/s12936-017-1759-2

Cited by 77 publications

(82 citation statements)

References 58 publications

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“…Richter et al have argued that evidence was not su cient to unequivocally demonstrate that P. ovale hypnozoites are found in the human host [17]. According to another review, only 18 cases of relapse for P. ovale have been recorded in nearly 100 years [18]. However, a recent study provides direct evidence, using molecular methods, of the reappearance of P. ovale curtisi strains, in line with currently accepted relapse theory.…”

Section: Discussionmentioning

confidence: 97%

Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012 – 2019

Zhang

Wang

Wang³

et al. 2020

Preprint

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Background Although autochthonous malaria cases are no longer reported in Anhui Province, China, imported malaria has become a major health concern. The proportion of reported malaria cases caused by Plasmodium ovale spp. increased to levels higher than expected during 2012 to 2019, and showed two peaks, 19.69% in 2015 and 19.35% in 2018. Methods We conducted a case-based retrospective study, using data collected from the China Information System for Disease Control and Prevention and Information System for Parasitic Disease Control and Prevention from 2012–2019, to describe the trends and differences between P. o. curtisi and P. o. wallikeri. Epidemiological characteristics were analyzed using descriptive statistics. Results P. ovale curtisi and P. ovale wallikeri were found simultaneously circulating in 14 African countries. Among 128 patients infected with P. ovale spp., the proportion of mixed infection cases was 10.16%. Six cases of co-infection by P. ovale and P. falciparum were observed, each presenting with two clinical attacks (the first attack was due to P. falciparum and the second was due to P. ovale spp.) at different intervals. Accurate identification of the infecting species was achieved in only 20.00% of cases with P. ovale infection. At the reporting units, 32.17% and 6.96% of P. ovale spp. cases were misdiagnosed as P. vivax and P. falciparum, respectively. Conclusion Our finding indicates that the ability of P. ovale spp. to co-infect with other malarial species has been previously underestimated and providing rational evidence for the existence of hypnozoites in P. ovale spp. P. o. curtisi and P. o. wallikeri circulate simultaneously in Africa, and the incidence of P. ovale spp. is probably also underestimated in these source countries where the disease is endemic. Given the low rate of species identification, more sensitive point-of-care detection methods need to be developed for P. ovale spp., and introduced in non-endemic areas.

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Section: Discussionmentioning

confidence: 97%

Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012 – 2019

Zhang

Wang

Wang³

et al. 2020

Preprint

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“…In series of imported malaria by P. falciparum the rate of severe cases was around 2–17% [ 11 , 34 ], but with a much higher incidence of life-threatening complications, such as ADRS, severe anaemia or cerebral malaria than described in P. ovale spp. infection [ 8 ]. A rare case of haemophagocytosis was included that had been described only in P. falciparum and P. vivax infection [ 35 ], but not in P. ovale spp.…”

Section: Discussionmentioning

confidence: 99%

“…The treatments were very varied, including artemisinins alone or in combination, atovaquone/proguanil, chloroquine or quinine-doxycycline, all with good initial clinical evolution, which is compatible with the sensitivity of P. ovale spp. described for multiple antimalarials [ 8 ]. Over 70% of them received primaquine with good tolerance, although there was no long-term follow-up recorded to assess episodes of relapse or late recrudescence.…”

Section: Discussionmentioning

confidence: 99%

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Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections

Marcos

Rubio

Angheben

et al. 2018

Malar J

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BackgroundFew previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences.MethodsPatients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods.ResultsA total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi.ConclusionsImported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection.

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“…Plasmodium causes the patient to suffer from malaria tertiana. Groger et al (2017) stated that the characteristics of patients affected by malaria tertiana include, rising body temperature, sweaty body, weak body condition and sometimes accompanied by dizziness or a headache. Figure 3 below shows the observed images of P. vivax infection in the trophozoite and gamete phases.…”

Section: Based Onmentioning

confidence: 99%

Types of Plasmodium and the Effect of Environmental Factor against Malaria in Manokwari, West Papua

Subekti

Paiticen

Kawulur

et al. 2018

JPII

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Malaria is a disease caused by parasitic protozoa (Plasmodium) carried by a vector of mosquitoes. There are approximately 100 million regions around the world at risk of malaria. One of the endemic areas of malaria in Indonesia is Papua. Manokwari is one of the districts in West Papua that has a high number of malaria patients. The purpose of this study was to investigate mosquitoes Plasmodium parasites, and malaria in West Manokwari District. The research procedure applied initial survey of the place where malaria vector was captured, capturing malaria vector, general environmental measurement, mosquito species identification, plasmodium examination on mosquito of malaria vector, and plasmodium examination on malaria patient. The total sample obtained from 3 areas was 1550 patients and 496 mosquitos with average numbers up to 150 mosquitos per area.The physical environment, including rainfall, temperature, humidity, altitude, and environmental conditions inside and outside the home greatly affected the incidence of Malaria in Manokwari, West Papua. Malaria is a serious health problem in Indonesia. The physical condition of the environment is the main factor influencing it.The results showed that the type of malaria vector found in West Manokwari region comes from two genera namely Culicidae and Anophelidae. Each malaria vector could carry infections from Plasmodium vivax or Plasmodium falciparum. There are two kinds of Plasmodium parasites that infected humans in Manokwari; Plasmodium falciparum and Plasmodium vivax.

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A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

Cited by 77 publications

References 58 publications

Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012 – 2019

Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012 – 2019

Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections

Types of Plasmodium and the Effect of Environmental Factor against Malaria in Manokwari, West Papua

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