A Systematic Study of the Pathogenicity of Sixty-Two Strains of Corynebacterium Renale for Laboratory White Mice

Abstract

Corynebacterium renale is the etiological agent of a specific cystitis and pyelonephritis of cattle. Aberrant C. renale infections have been reported in a horse by Foss (1944), in horses and sheep by Boyd and Bishop (1937), and in a dog by Olafson (1930). Ernst (1906) and Jones and Little (1926) were unable to infect mice with C. renale. Lovell (1946) reported that C. renale was pathogenic for mice provided an adequate number were given intravenously. Morse and Morgan (1951) were able to infect mice by intravenous and intraperitoneal inoculations of strains of C. renale which were isolated from the urine or posterior urogenital tracts of apparently normal cattle. Morse and Wipf (1951) studied the epizootiology, pathogenicity, and pathogenesis of a diphtheroid which, although it resembled

Experimental Rat model for Corynebacterium renale-induced pyelonephritis

“…Histological examination of the urinary bladder did on occasion reveal calcareous deposits within the bladder tissue itself in both C. renale-infected and control rats. Kuzdas et al (13), using mice intravenously injected with C. renale, noted necrotic areas in the kidneys of these mice at necropsy and observed, "When such kidneys were minced with scissors, a slight grating sound was produced indicating the presence of minute calculi. A similar condition, with the presence of calcareous deposits, has been observed in bovine pyelonephritis.…”

“…The study of the pathogenesis of this disease has been hampered by the lack of a good experimental model. Until recently (20), experimental infections have been achieved in laboratory animals, notably mice, only by the hematogenous route (13,(15)(16)(17).…”