2014
DOI: 10.1039/c4bm00007b
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A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors

Abstract: High-performance illumination of subcutaneous tumor and liver tumor foci at sub-millimeter levels was achieved with lectin-targeted glyco-micelles which become fluorescent upon internalization into tumor lysosomes.

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Cited by 28 publications
(19 citation statements)
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“…We previously reported the use of rhodamine-lactams for imaging of lysosomal acidity and lysosomal pH based tumor imaging. [13][14][15][16][17][18][19][20][21][22] Herein rhodamine-lactams were conjugated with bacterium-homing entities to envelope rhodamine-lactams within bacteria for reporting phagolysosomal acidity during bacterial phagocytosis.…”
Section: Resultsmentioning
confidence: 99%
“…We previously reported the use of rhodamine-lactams for imaging of lysosomal acidity and lysosomal pH based tumor imaging. [13][14][15][16][17][18][19][20][21][22] Herein rhodamine-lactams were conjugated with bacterium-homing entities to envelope rhodamine-lactams within bacteria for reporting phagolysosomal acidity during bacterial phagocytosis.…”
Section: Resultsmentioning
confidence: 99%
“…The chemical compound HAuCl 4 (tetrachloroaurate/auric acid) of $2.5 g was taken in a 250 mL RB ask (round bottom ask). This has been added with $60 mL of organic solvent DMF (dimethyl formamide) and allowed to stir for 12 h at 50 C. This is again added with the 0.5 g of NaBH 4 (sodium borohydrate) strong reducing agent and allowed to stir for 2 h at 50 C. Furthermore, to that mixture methanol (MeOH) $25 mL has been added and allowed to stir for 2 h at 50 C. 1,11,17,25 Finally, the sodium metal from reducing agent NaBH 4 was degraded with the methanol solvent. The end product of reaction was yellowish in colour and this solution was used to separate the metal (Au) nanoparticles through the high speed centrifugation at 10 000 RPM for 10 minutes.…”
Section: Synthesis Of Aunps With An Avg Size Of 10 Nmmentioning
confidence: 99%
“…The organic polar environment is the main factor to affect or reduce the AuNPs size along with strong reducing agents. [1][2][3][4][19][20][21][22][23][24][25][26][27][28]36 These are showing signicant inuence on controlling the metal nanoparticle size, shape and morphology through the self-assembly and affinity between metal atoms and polar solvents with the help of reducing agents as size changing agents. The Fig.…”
Section: Particle Size Analysismentioning
confidence: 99%
“…Thus, in recent years, some efforts have also been devoted to the deregulated tumor metabolism, i.e., aerobic glycolysis (also known as Warburg effect), [23, 24] which creates a cancer‐specific microenvironment regardless of cancer types, such as the decreased pH (acidic extracellular macroenvironment) and the enhanced levels of intracellular glutathione (GSH) and reactive oxygen species (ROS). However, since both pH and GSH levels between cancerous and normal tissues are not very different (pH 6.5–6.9 for tumor microenvironment and 7.4 for normal tissues; [25] intracellular GSH levels for cancer and normal cells are in 2–13 mM), [26, 27] the efficacy of the pH‐ or GSH‐based fluorescent probes still remains challenging, and indeed only a limited number of examples of success have been reported to date [28–35] …”
Section: Introductionmentioning
confidence: 99%