1999
DOI: 10.1006/bulm.1999.0121
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A Theoretical Experimental Method to Determine the Locus of Desensitization

Abstract: Consider a ligand-gated channel with n agonist binding sites which can undergo desensitization. We present a theoretical experimental procedure for pinpointing the principal receptor state from which there is a transition to the desensitized state. The method is based on the observation that the dependence of the slope of the time constant of desensitization vs agonist concentration, at low concentrations, represents the state from which desensitization occurs. In those receptors where desensitization occurs f… Show more

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Cited by 3 publications
(2 citation statements)
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“…Franke et al (1993) and Buchman and Parnas (1999) showed that when desensitization occurs primarily from the doubly liganded state (as for the nicotinic receptor), D declines monotonously as agonist concentration rises. On the other hand, when desensitization occurs also from other states of the receptor, D exhibits a complex dependence on agonist concentration.…”
Section: Dependence Of D On Glutamate Concentrationmentioning
confidence: 99%
See 1 more Smart Citation
“…Franke et al (1993) and Buchman and Parnas (1999) showed that when desensitization occurs primarily from the doubly liganded state (as for the nicotinic receptor), D declines monotonously as agonist concentration rises. On the other hand, when desensitization occurs also from other states of the receptor, D exhibits a complex dependence on agonist concentration.…”
Section: Dependence Of D On Glutamate Concentrationmentioning
confidence: 99%
“…The independence of D on glutamate concentration suggests that desensitization occurs from at least two states of the receptor, the fully liganded state and a partly liganded state (Buchman and Parnas 1999;Franke et al 1993).…”
Section: Predesensitization By a Low Concentration Of Glutamatementioning
confidence: 99%