A three month inhalation toxicity study in the squirrel monkey (Saimiri sciureus) with terbutaline sulfate (Bricanyl®)

Levinsky, H.V.; Procter, B. G.; Malmfors, Törbjorn; MacFarland, H. N.; Róna, G

doi:10.1016/s0300-483x(78)91939-x

Cited by 3 publications

(2 citation statements)

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“…Such observations run with that obtained by Levinsky et al. ( 1978 ) who declared safety and tolerability of TBN following a three-month investigation of inhalation-toxicity in squirrel monkeys. Additionally, the results demonstrated the absence of acute toxicity related to the nano-cargo components.…”

Section: In Vivo Studiessupporting

confidence: 88%

Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation

et al. 2022

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Asthma represents a globally serious non-communicable ailment with significant public health outcomes for both pediatrics and adults triggering vast morbidity and fatality in critical cases. The β 2 -adrenoceptor agonist, terbutaline sulfate (TBN), is harnessed as a bronchodilator for monitoring asthma noising symptoms. Nevertheless, the hepatic first-pass metabolism correlated with TBN oral administration mitigates its clinical performance. Likewise, the regimens of inhaled TBN dosage forms restrict its exploitation. Consequently, this work is concerned with the assimilation of TBN into a novel non-phospholipid nanovesicular paradigm termed novasomes (NVS) for direct and effective TBN pulmonary targeting. TBN-NVS were tailored based on the thin film hydration method and Box-Behnken design was applied to statistically optimize the formulation variables. Also, the aerodynamic pattern of the optimal TBN-NVS was explored via cascade impaction. Moreover, comparative pharmacokinetic studies were conducted using a rat model. TBN elicited encapsulation efficiency as high as 70%. The optimized TBN-NVS formulation disclosed an average nano-size of 223.89 nm, ζ potential of −31.17 mV and a sustained drug release up to 24 h. Additionally, it manifested snowballed in vitro lung deposition behavior in cascade impactor with a fine particle fraction of 86.44%. In vivo histopathological studies verified safety of intratracheally-administered TBN-NVS. The pharmacokinetic studies divulged 3.88-fold accentuation in TBN bioavailability from the optimum TBN-NVS versus the oral TBN solution. Concisely, the results proposed that NVS are an auspicious nanovector for TBN pulmonary delivery with integral curbing of the disease owing to target specificity.

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Section: In Vivo Studiessupporting

confidence: 88%

Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation

et al. 2022

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“…With regard to the chick model, it is unlikely that the disparity represents differential sensitivities of the two species. In the adult, avian and rodent species show similar sensitivities to terbutaline-induced cardiac damage (Marmo et al, 1974;Magnusson and Hansson, 1973;Whitehurst et al, 1994), although some species of squirrels are indeed resistant (Levinsky et al, 1978). One important difference, however, is that drugs introduced into the chick egg are not subject to placental clearance or maternal drug metabolism and hence act throughout the pre-hatch period.…”

Section: Discussionmentioning

confidence: 99%