A time-of-flight secondary ion microscope

Schueler, B.; Sander, P.; Reed, David

doi:10.1016/0042-207x(90)94047-t

Cited by 97 publications

(63 citation statements)

References 4 publications

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“…The secondary ion mass analyses were performed in a Phi-EVANS (Chanhassen, MN, USA) time-of-flight SIMS (TRIFT 1) using a 15 keV Ga ϩ beam (ϳ1 nA DC current; 22 ns pulse width bunched down to 1 ns; 5 kHz repetition rate) with the sample voltage at 3 kV [28]. To improve the measured intensities, the secondary ions were post-accelerated by a high voltage (7 kV) in front of the microchannel plate detector.…”

Section: Tof-sims Instrumentmentioning

confidence: 99%

Organic secondary ion mass spectrometry: Signal enhancement by water vapor injection

Mouhib

Delcorte

Poleunis

et al. 2010

J. Am. Soc. Mass Spectrom.

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The enhancement of the static secondary ion mass spectrometry (SIMS) signals resulting from the injection, closely to the sample surface, of H 2 O vapor at relatively high-pressure, was investigated for a set of organic materials. While the ion signals are generally improved with increasing H 2 O pressure upon 12 keV Ga ϩ bombardment, a specific enhancement of the protonated ion intensity is clearly demonstrated in each case. For instance, the presence of H 2 O vapor induces an enhancement by one order of magnitude of the [M ϩ H] ϩ static SIMS intensity for the antioxidant Irgafos 168 and a ϳ1.5-fold increase for polymers such as poly(vinyl pyrrolidone).

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Section: Tof-sims Instrumentmentioning

confidence: 99%

Organic secondary ion mass spectrometry: Signal enhancement by water vapor injection

Mouhib

Delcorte

Poleunis

et al. 2010

J. Am. Soc. Mass Spectrom.

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“…To characterize Sr incorporation with depth into the precipitates, time-of-flight secondary ion mass spectrometry (ToF-SIMS) analyses were performed using a Charles Evans & Associates instrument (Schueler et al, 1990), in the user facility at the Image and Chemical Analysis Laboratory at Montana State University. The solid particles were pressed into indium foil and coated with 10 nm of gold before mounting in the sample holder to prevent charging.…”

Section: Tof-sims Analysis and Determination Of Sputter Depth By Afmmentioning

confidence: 99%

Strontium incorporation into calcite generated by bacterial ureolysis

Fujita

Redden

Ingram

et al. 2004

Geochimica et Cosmochimica Acta

214

141

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Abstract-Strontium incorporation into calcite generated by bacterial ureolysis was investigated as part of an assessment of a proposed remediation approach for 90 Sr contamination in groundwater. Urea hydrolysis produces ammonium and carbonate and elevates pH, resulting in the promotion of calcium carbonate precipitation. Urea hydrolysis by the bacterium Bacillus pasteurii in a medium designed to mimic the chemistry of the Snake River Plain Aquifer in Idaho resulted in a pH rise from 7.5 to 9.1. Measured average distribution coefficients (D EX ) for Sr in the calcite produced by ureolysis (0.5) were up to an order of magnitude higher than values reported in the literature for natural and synthetic calcites (0.02-0.4). They were also higher than values for calcite produced abiotically by ammonium carbonate addition (0.3). The precipitation of calcite in these experiments was verified by X-ray diffraction. Time-of-flight secondary ion mass spectrometry (ToF SIMS) depth profiling (up to 350 nm) suggested that the Sr was not merely sorbed on the surface, but was present at depth within the particles. X-ray absorption near edge spectra showed that Sr was present in the calcite samples as a solid solution. The extent of Sr incorporation appeared to be driven primarily by the overall rate of calcite precipitation, where faster precipitation was associated with greater Sr uptake into the solid. The presence of bacterial surfaces as potential nucleation sites in the ammonium carbonate precipitation treatment did not enhance overall precipitation or the Sr distribution coefficient. Because bacterial ureolysis can generate high rates of calcite precipitation, the application of this approach is promising for remediation of 90 Sr contamination in environments where calcite is stable over the long term.

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“…Alternatively, the TRIFT line of SIMS mass spectrometers from Physical Electronics employ a series of three electrostatic analyzers (ESAs) along the ion flight path to account for kinetic energy differences among the ions. To compensate for the small velocity differences of individual ions, three 90° turns in the ion path function much like the reflectron described earlier by causing ions of different kinetic energy, but with the same nominal m/z, to travel slightly longer or shorter paths before reaching the detector (Schueler et al 1990;Szakal et al 2006).…”

Section: B Simsmentioning

confidence: 99%

Chapter 13 Imaging of Cells and Tissues with Mass Spectrometry

Zimmerman

Monroe

Tucker

et al. 2008

Methods in Cell Biology

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Techniques that map the distribution of compounds in biological tissues can be invaluable in addressing a number of critical questions in biology and medicine. One of the newest methods, mass spectrometric imaging, has enabled investigation of spatial localization for a variety of compounds ranging from atomics to proteins. The ability of mass spectrometry to detect and differentiate a large number of unlabeled compounds makes the approach amenable to the study of complex biological tissues. This chapter focuses on recent advances in the instrumentation and sample preparation protocols that make mass spectrometric imaging of biological samples possible, including strategies for both tissue and single cell imaging using the following mass spectrometric ionization methods: matrix-assisted laser desorption/ionization, secondary ion, electrospray and desorption electrospray.

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A time-of-flight secondary ion microscope

Cited by 97 publications

References 4 publications

Organic secondary ion mass spectrometry: Signal enhancement by water vapor injection

Organic secondary ion mass spectrometry: Signal enhancement by water vapor injection

Strontium incorporation into calcite generated by bacterial ureolysis

Chapter 13 Imaging of Cells and Tissues with Mass Spectrometry

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