A traditional painkiller as a probe for microheterogeneity in 1-propanol–water mixtures

Chakraborty, Sreeja; Sehanobish, Esha; Sarkar, Munna

doi:10.1016/j.cplett.2010.10.050

Cited by 13 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sarkar and co-workers also reported the lifetime components of IMC in alcohol-water binary mixtures. [46,47] In the present system, we have observed that the components are remarkably modified upon addition of the CD molecular containers. In the presence of 13 mm a-CD, the fast lifetime component (t 1 ) of IMC decreases slightly and the slow component (t 2 ) increases, with no change in their relative population.…”

Section: Time-resolved Fluorescence Emission Measurementsmentioning

confidence: 92%

“…IMC shows two characteristic absorption peaks at 267 and 320 nm, which are characteristic of IMC. [46,47] With the gradual addition of the macrocycle hosts (CDs), the first absorption peak position of IMC shows a hypsochromic shift, whereas the second peak position remains almost unchanged. It was also observed that upon successive addition of CDs (a-CD, b-CD, g-CD and 2-HP-g-CD) the absorbance of IMC gradually increased.…”

Section: Steady-state Absorption Studiesmentioning

confidence: 97%

“…Sarkar and co-workers reported that IMC can sense the microheterogenity that exists in binary alcohol-water mixtures. [46,47] The perception of molecular reorganisation of host-guest complex formation of the drug molecule on a molecular level plays a vital role in biological systems and is highly significant. Information gathered on the photophysics of these systems can lead to a better understanding of the diverse applications of the IMC molecule.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

et al. 2014

View full text Add to dashboard Cite

Supramolecular host-guest complexation between the nonsteroidal anti-inflammatory drug indomethacin (IMC) and molecular containers were investigated. The weakly fluorescent drug molecule becomes highly fluorescent on complexation with different molecular containers, and time-resolved fluorescence emission spectroscopy reveals that the lifetime components of IMC significantly increase in the presence of molecular containers, compared with the lifetimes in neat water. The respective solid host-guest complexes were synthesised and characterised by Fourier transform infrared and (1) H nuclear magnetic resonance spectroscopic analysis. Microscopy techniques were used to analyse modifications of the surface morphology, owing to the formation of supramolecular complexes. The effect of the molecular container on the optical properties of IMC has also been investigated to determine the effect of nanochannels of different size and structure.

show abstract

Section: Time-resolved Fluorescence Emission Measurementsmentioning

confidence: 92%

Section: Steady-state Absorption Studiesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This indicates that the interaction principally takes place in the electronic excited state (Figs. [13][14][15]. Quenching constants in different environments have been measured (Table 3) using Stern-Volmer Eq.…”

Section: Dynamic Fluorescence Quenching Of Kthc-57 In Presence Of Teamentioning

confidence: 99%

“…We have then studied the spectroscopic behaviour of KTHC-57 in different binary mixtures. Importance of binary mixtures lies in the fact that, they are macroscopically homogeneous in nature but they possess remarkably complex structures with very strong spatial non-homogeneity on a scale of few molecular sizes [12][13][14][15][16][17][18][19][20][21]. Their chemical possessions can be easily modulated by just altering their mixing ratios.…”

Section: Introductionmentioning

confidence: 99%

Solution phase photophysics of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one: Analysing the lineaments of a new fluorosensor to probe different micro-environments

Mitra¹,

Ghosh

et al. 2015

Journal of Luminescence

View full text Add to dashboard Cite

A New Remote Control for Traceless meta‐CH Olefination of Phenols

Martı́nez¹,

Muñiz²

2013

ChemCatChem

View full text Add to dashboard Cite

The development of a suitable methodology for the introduction of functional groups into the core of aromatic molecules has continued to be an indicator of synthetic progress for over a century. It was already considered of utmost importance nearly 150 years ago, when Kekule dedicated his Chemie der Benzolderivate oder der aromatischen Verbindungen to this particular topic. [1] Within the field of modern arene chemistry, [2] the general concept of direct CÀH functionalization of arenes represents an area with particularly impressive advances over recent years. Classic concepts rely on suitable directing groups for ortho-functionalization. This concept was widely explored for stoichiometric ortho-lithiation, [3] as well as in more recent developments employing transition metal based catalysts, which rely on cyclometalation reactions, where palladium and ruthenium have played prominent roles.[4] In addition to conventional ortho-functionalization, some groups have recently started to explore the development of suitable catalytic conditions for meta-selective CÀH derivatization of arenes. [5] Some time ago, Yu described an important break-through in the field of palladium catalysis. By designing suitable directing groups containing nitrile substituents, his group was able to devise an efficient chelation control in order to generate a coordinated palladium complex A and to direct the cyclopalladation to proceed preferentially at the meta-position (Scheme 1). [6] Although representing a striking methodological accomplishment, removal of the directing group was not straightforward. Readily cleavable directing groups have emerged among recent progress in the area of palladium-catalyzed CÀH derivatization. [7] Following this approach, Yu has now built upon this earlier concept of nitrile-chelation control for palladium-catalyzed position-selective olefination of arenes. This new protocol contains two important accomplishments: the parent arene is a phenol unit and the directing group undergoes traceless removal. Directing a CÀH functionalization into the meta-position of a phenol derivative constitutes a chemical transformation that is not possible through classic aromatic substitution chemistry. To realize such meta-position selectivity, Yu recurred to an a-phenoxy acetamide bearing two nitrile-chelating groups. Upon coordination to palladium, the combination of two appropriate groups should place the metal in close proximity to the meta-position of the phenol substrate, thereby promoting the desired CÀH palladation to take place selectively (Scheme 2).Based on this elegant design, the desired meta-functionalization became indeed possible through a 13-membered cyclopalladated intermediate. Under catalytic conditions, the concept of meta-CÀH functionalization was validated for a series of olefination reactions. A catalyst from palladium acetate, N-acetyl glycine as ligand 2 and silver acetate as terminal oxidant generate the best reaction conditions for the conversion of a number of phenol derivatives 1 (Scheme 3). ...

show abstract

A traditional painkiller as a probe for microheterogeneity in 1-propanol–water mixtures

Cited by 13 publications

References 17 publications

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

Solution phase photophysics of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one: Analysing the lineaments of a new fluorosensor to probe different micro-environments

A New Remote Control for Traceless meta‐CH Olefination of Phenols

Contact Info

Product

Resources

About