A Twenty-Five Year Review of Laboratory-Acquired Human Infections at the National Animal Disease Center

Miller, C.D.; Songer, J. R.; Sullivan, James F.

doi:10.1080/15298668791384733

Cited by 52 publications

(20 citation statements)

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“…Accidents with risk category 4 organisms. LAIs with category 4 biological agents (filoviruses, arenaviruses, flaviviruses, and bunyaviruses) are extremely rare and usually occurred earlier in settings with lower levels of biocontainment and/or involved animal work (41,42,51,91,127,138,139,114). Rare laboratory incidents with New World arenaviruses have been reported in earlier surveys more than 4 to 5 decades ago (e.g., with Junin virus and Machupo virus) (51).…”

Section: Are Laboratory Workers and The Environment Protected Againstmentioning

confidence: 99%

Evidence-Based Biosafety: a Review of the Principles and Effectiveness of Microbiological Containment Measures

Kimman

Smit

Klein³

2008

Clin Microbiol Rev

101

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SUMMARY We examined the available evidence on the effectiveness of measures aimed at protecting humans and the environment against the risks of working with genetically modified microorganisms (GMOs) and with non-GMO pathogenic microorganisms. A few principles and methods underlie the current biosafety practice: risk assessment, biological containment, concentration and enclosure, exposure minimization, physical containment, and hazard minimization. Many of the current practices are based on experience and expert judgment. The effectiveness of biosafety measures may be evaluated at the level of single containment equipment items and procedures, at the level of the laboratory as a whole, or at the clinical-epidemiological level. Data on the containment effectiveness of equipment and laboratories are scarce and fragmented. Laboratory-acquired infections (LAIs) are therefore important for evaluating the effectiveness of biosafety. For the majority of LAIs there appears to be no direct cause, suggesting that failures of biosafety were not noticed or that containment may have been insufficient. The number of reported laboratory accidents associated with GMOs is substantially lower than that of those associated with non-GMOs. It is unknown to what extent specific measures contribute to the overall level of biosafety. We therefore recommend that the evidence base of biosafety practice be strengthened.

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Section: Are Laboratory Workers and The Environment Protected Againstmentioning

confidence: 99%

Evidence-Based Biosafety: a Review of the Principles and Effectiveness of Microbiological Containment Measures

Kimman

Smit

Klein³

2008

Clin Microbiol Rev

101

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“…A 25-year (1960 to 1985) review of laboratory-acquired infections at the National Animal Disease Center summarizes the risks associated with working in an animal research facility (Table 1) (93). As reported in the other laboratory surveys, Chlamydia spp., Brucella spp., and Mycobacterium spp.…”

Section: Survey Of Laboratory-associated Infectionsmentioning

confidence: 99%

Laboratory-associated infections and biosafety.

Sewell¹

1995

Clinical Microbiology Reviews

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“…In 1987, Miller et al (133) updated the previous study (202) at the National Animal Disease Center and included data for the preceding 25 years on laboratory-acquired infections. Vesley and Hartmann (212) sent questionnaires to 54 state and territorial health departments in the United States and to 165 clinical laboratories in Minnesota, with response rates of 79.6% from health departments and 90.3% from state clinical laboratories.…”

Section: Laboratory-acquired Infections Historical Perspectivementioning

confidence: 99%

Biological safety cabinetry.

Kruse¹,

Puckett²,

Richardson³

1991

Clinical Microbiology Reviews

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tively, not divine origin, induced disease. In 1546, Fracastorius described the agent of communicable disease as a living contagium vivum that spread by direct contact, by intermediary fomites, or through the air and postulated that these living seeds, passed from one infected animal, produced the same disease in an animal that received them. In 1676, Leeuwenhoek discovered and described bacteria, but bacteriology as a science dates from the middle of the 19th century, a result of the scientific studies of Louis Pasteur. Microbiologists are cognizant of his study disproving the theory of spontaneous generation and his work with cultures and the propagation of bacteria; however, because all of the media were fluid, these methods were not applicable for isolating a single microorganism from mixed cultures. Robert Koch's studies with nutrient gelatin and, later, solid 207

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A Twenty-Five Year Review of Laboratory-Acquired Human Infections at the National Animal Disease Center

Cited by 52 publications

References 0 publications

Evidence-Based Biosafety: a Review of the Principles and Effectiveness of Microbiological Containment Measures

Evidence-Based Biosafety: a Review of the Principles and Effectiveness of Microbiological Containment Measures

Laboratory-associated infections and biosafety.

Biological safety cabinetry.

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