2019
DOI: 10.3390/pharmaceutics11090468
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A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

Abstract: Calcium phosphate (CaP) nanoparticles, as a promising vehicle for gene delivery, have been widely used owing to their biocompatibility, biodegradability and adsorptive capacity for nucleic acids. Unfortunately, their utility in vivo has been profoundly restricted due to numerous technical barriers such as the lack of tissue specificity and limited transfection efficiency, as well as uncontrollable aggregation over time. To address these issues, an effective conjugate folate-polyethylene glycol-pamidronate (sho… Show more

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Cited by 5 publications
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“…
Fig. 7 Schematic representation of the preparation and application of PEG-derivatives functionated calcium phosphate NPs: A) PEG-bisphosphonates [ 63 ], B) PEG-CCP [ 64 ], C) PEG–SS–siRNA [ 67 ], D) FA-PEG-Pam [ 146 ] and E) PEG-PLG-GEM [ 68 ].
…”
Section: Application Of Calcium Phosphate Nanocarriersmentioning
confidence: 99%
See 1 more Smart Citation
“…
Fig. 7 Schematic representation of the preparation and application of PEG-derivatives functionated calcium phosphate NPs: A) PEG-bisphosphonates [ 63 ], B) PEG-CCP [ 64 ], C) PEG–SS–siRNA [ 67 ], D) FA-PEG-Pam [ 146 ] and E) PEG-PLG-GEM [ 68 ].
…”
Section: Application Of Calcium Phosphate Nanocarriersmentioning
confidence: 99%
“…Several approaches have been investigated to overcome this hurdle, including adding specific ligands to target the desired cells and introducing cleavable PEG systems. Based on this, an effective conjugate folate-polyethylene glycol-pamidronate (shortened as FA-PEG-Pam) was designed and coated on the surface of CaP/NLS/pDNA (CaP/NDs), forming a versatile gene carrier FA-PEG-Pam/CaP/NDs [ 146 ]. Inclusion of FA-PEG-Pam significantly reduced the size of CaP nanoparticles, thus inhibiting the aggregation of CaP nanoparticles ( Fig.…”
Section: Application Of Calcium Phosphate Nanocarriersmentioning
confidence: 99%