A very rare cause of male breast lump: Idiopathic granulomatous mastitis

Elibol, Funda Dinç; Elibol, Cenk; Tekin, Leyla; Dönmez, Cem

doi:10.1111/tbj.13571

Cited by 4 publications

(5 citation statements)

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“…Although GLM is a benign disease, mastectomy may be performed, which may result in loss of the breast and cause serious impacts on patients' physical and mental health. GLM generally affects young women of childbearing age with a history of parity and lactation and can occasionally occur in the nulliparous and in men [21][22][23][24]. In our study, lesions were consistent with previous studies [25].…”

Section: Discussionsupporting

confidence: 93%

Clinicopathologic Features and Pathogens of Granulomatous Lobular Mastitis

Chen

Wang

et al. 2023

Breast Care

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Background: Granulomatous lobular mastitis (GLM) is a rare, benign, and complex breast disease that can be easily misdiagnosed as breast cancer. The etiology of GLM is unclear and optimal treatment has not been established. Methods: Medical records for 333 patients with GLM in recent five years at Longhua Hospital, based in Shanghai, China, were analyzed. Potential pathogens in 33 fresh tissue specimens were also analyzed using 16S rDNA sequencing technology, matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS), and bacterial cultures. Results: The median age of patients was 32 years (range 22-47 years). Amongst 333 patients, 38.7% displayed elevated prolactin, while 23.7% displayed high interleukin-2.In the granulomatous lesion, CD3 positive T lymphocytes were significantly more than CD20 positive B lymphocytes around the vacuoles or microabscesses. Gram-positive organisms were observed in 82 cases, including in 22 cases from fresh tissue specimens. Thirty-three (33) cases yielded associated pathogens and all displayed multiple pathogenic infections, as identified using 16S rDNA sequencing technology. Pathogenic infections were further identified as belonging to 16 main genera and 8 main pathogenic species. Conclusions: GLM displays distinct histological and clinical features similarly to those have been previously reported in literatures. Using 16S rDNA sequencing technology, all of our cases demonstrated multiple pathogenic infections, which provided more useful information for clinical treatment.

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Section: Discussionsupporting

confidence: 93%

Clinicopathologic Features and Pathogens of Granulomatous Lobular Mastitis

Chen

Wang

et al. 2023

Breast Care

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“…To the best of our knowledge, there are only 16 reported cases of GM in male patients. 1,2,[4][5][6][7][8][9][10][11][12][13][14][15] The reported cases have been summarized in Table 1. We analyzed 12 cases of patients whose characteristics and clinical courses were described.…”

Section: Discussionmentioning

confidence: 99%

“…We analyzed 12 cases of patients whose characteristics and clinical courses were described. 2,[6][7][8][9][10][11][12][13][14][15] The median age of the patients at the time of presentation was 46 years (range: 17-60 years). Eight patients (73%) had GM in the right breast, while two (17%) presented with bilateral involvement.…”

Section: Discussionmentioning

confidence: 99%

“…GM is rarely observed in males. To the best of our knowledge, there are only 16 reported cases of GM in male patients 1,2,4–15 . The reported cases have been summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…The reported cases have been summarized in Table 1. We analyzed 12 cases of patients whose characteristics and clinical courses were described 2,6–15 . The median age of the patients at the time of presentation was 46 years (range: 17–60 years).…”

Section: Discussionmentioning

confidence: 99%

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