A water-soluble phosphorescent conjugated polymer brush for tumor-targeted photodynamic therapy

Sun, Pengfei; Wang, Gaina; Hou, Huanzhi; Yuan, Peng; Deng, Weixing; Wang, Chao; Lü, Xiaomei; Fan, Quli; Huang, Wei

doi:10.1039/c7py01248a

Cited by 45 publications

(38 citation statements)

References 30 publications

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“…The polymer (PPF-Ir-g-(POEGMA-b-PGal)) of Lu et al after light irradiation showed an efficient xenograft Hep G2 tumor inhibition and a high apoptosis level in vitro. At the same time this polymer showed a low dark toxicity in vivo [69].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 71%

The Dark Side: Photosensitizer Prodrugs

2019

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Photodynamic therapy (PDT) and photodiagnosis (PD) are essential approaches in the field of biophotonics. Ideally, both modalities require the selective sensitization of the targeted disease in order to avoid undesired phenomena such as the destruction of healthy tissue, skin photosensitization, or mistaken diagnosis. To a large extent, the occurrence of these incidents can be attributed to “background” accumulation in non-target tissue. Therefore, an ideal photoactive compound should be optically silent in the absence of disease, but bright in its presence. Such requirements can be fulfilled using innovative prodrug strategies targeting disease-associated alterations. Here we will summarize the elaboration, characterization, and evaluation of approaches using polymeric photosensitizer prodrugs, nanoparticles, micelles, and porphysomes. Finally, we will discuss the use of 5-aminolevulinc acid and its derivatives that are selectively transformed in neoplastic cells into photoactive protoporphyrin IX.

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Section: Polymeric Nanoparticlesmentioning

confidence: 71%

The Dark Side: Photosensitizer Prodrugs

2019

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“…Glycopolymer bottlebrushes are usually obtained by “grafting from” of monomers, using a previously prepared multifunctional polymer backbone [ 31 , 32 , 33 ]. Both backbone and side chains can be synthesized by the combination of RDRP methods, such as RAFT and ATRP [ 33 ], or with other polymerization techniques, like ring-opening polymerization (ROP) [ 32 ].…”

Section: Preparation Of Polymer Brushes By Rdrpmentioning

confidence: 99%

“…Another common application for galactose-containing polymers is tumor-targeted therapy [ 27 , 31 , 98 , 99 ] because of the ability of galactose to recognize and target hepatocellular carcinoma cells (HepG2) [ 31 , 100 , 101 ]. As an example, a fluorescent galactose-containing glyco(co)polymer brush was synthesized to improve tumor-targeted photodynamic therapy, which uses photosensitizers and light to generate reactive oxygen species (ROS) that can induce cell death [ 31 ]. First, a photosensitizer metal complex Ir(III)-terminated bromine multifunctional poly(benzene- alt- fluorene) ATRP macroinitiator (PFF-Ir) was used to block the copolymerization of oligo(ethylene glycol) methacrylate (OEGMA) and glycidyl methacrylate (GMA) by ATRP (PPF-Ir- g -(POEGMA- b -PGMA)).…”

Section: Galactose-containing Polymer Brushesmentioning

confidence: 99%

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

et al. 2020

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The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested.

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“…[9][10][11][12] Besides, photodynamic therapy (PDT) also acts as a decent therapeutic approach toward cancer or other diseases based on the generation of reactive oxygen species (ROS) induced by the photosensitizer (PS)-assisted light energy transfer to surrounding oxygen. 13 Thus, rational combination of advanced imaging and therapeutic techniques not only enables accurate and effective treatment toward diseases but also provides realtime monitoring of therapeutic efficacy during and after the therapeutic process, which has attracted tremendous attention in biomedical field. In phototheranostics, light source is an indispensable element.…”

Section: Introductionmentioning

confidence: 99%

Organic semiconducting nanomaterials‐assisted phototheranostics in near‐infrared‐II biological window

Yin

Lü

Fan

et al. 2020

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Phototheranostics conducted in the near-infrared-II (NIR-II) biological window exhibits high superiorities relative to that conducted in the first near-infrared (NIR-I) window due to higher penetration depth, higher signal-to-noise ratio of imaging, and improved maximum permissible exposure. Currently, most existing agents developed for NIR-II phototheranostics are limited to inorganic nanoparticles and small-molecule dyes, which suffer from the issues of longterm biotoxicity and poor photostability, respectively. Organic semiconducting nanomaterials (OSNs) constructed from π-conjugated organic semiconducting polymers or oligomers have unique advantages including high photostability, flexible optical features, and good biocompatibility due to the totally organic and biologically inert constituents. These advantages make OSNs more promising for in vivo phototheranostics. We here make a brief review about recent progress of OSNs-assisted phototheranostics conducted in the NIR-II biological window. NIR-II fluorescence imaging and photoacoustic imaging are mainly reviewed as diagnostic modalities to guide various treatments. Besides, multimodal phototheranostics using OSNs in NIR-II window is also described. At last, the challenges and outlook for OSNs-assisted NIR-II phototheranostics are discussed. K E Y W O R D S cancer therapy, fluorescence imaging, organic semiconducting nanoparticle, photoacoustic imaging, second near-infrared window This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A water-soluble phosphorescent conjugated polymer brush for tumor-targeted photodynamic therapy

Abstract: A glycopolymer modified water-soluble conjugated polymer brush was developed for Hep G2 tumor targeted photodynamic therapy.

Cited by 45 publications

References 30 publications

The Dark Side: Photosensitizer Prodrugs

The Dark Side: Photosensitizer Prodrugs

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

Organic semiconducting nanomaterials‐assisted phototheranostics in near‐infrared‐II biological window

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